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Q8FXY4

- TRPB_BRUSU

UniProt

Q8FXY4 - TRPB_BRUSU

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Protein
Tryptophan synthase beta chain
Gene
trpB, BR2110, BS1330_I2104
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chain (EC:4.2.1.20)
Gene namesi
Name:trpB
Ordered Locus Names:BR2110, BS1330_I2104
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Tryptophan synthase beta chainUniRule annotation
PRO_0000098925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains By similarity.

Protein-protein interaction databases

STRINGi204722.BR2110.

Structurei

3D structure databases

ProteinModelPortaliQ8FXY4.
SMRiQ8FXY4. Positions 20-403.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.

Phylogenomic databases

eggNOGiCOG0133.
HOGENOMiHOG000161710.
KOiK01696.
OMAiEFMTLLQ.
OrthoDBiEOG6GFGH7.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FXY4-1 [UniParc]FASTAAdd to Basket

« Hide

MNKPVAPNSY KTGPDEEGMF GIFGGRFVAE TLMPLILELQ QAYETAKNDP    50
EFKAELNALS TFYAGRPSKL YYAEGLSKHL GGAKIYFKRE DLNHTGSHKI 100
NNCLGQILLA KRMGKTRIIA ETGAGQHGVA SATVAARFGL PCIVYMGATD 150
VERQKPNVFR MKLLGAEVKP VSAGNGTLKD AMNEALRDWV TNVEDTYYLI 200
GTAAGPHPYP ELVRDFQSVI GTEARQQILE QEGRLPDVIV AAVGGGSNAI 250
GLFHPFLDDA SVKIVGVEAG GRGLEGEEHC ASMSAGRPGV LHGNRTYLLQ 300
NADGQILEGH SVSAGLDYPG VGPEHSWLKD SGRVDYVPIL DNEALDAFQL 350
CTRTEGIIPA LESAHAIAQA VKMAPTMGKD KVMIVNLSGR GDKDVHTVGK 400
LLGMDI 406
Length:406
Mass (Da):43,571
Last modified:March 1, 2003 - v1
Checksum:i5DC87B86C3CDFFA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31000.1.
CP002997 Genomic DNA. Translation: AEM19417.1.
RefSeqiNP_699085.1. NC_004310.3.
YP_005616909.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN31000; AAN31000; BR2110.
AEM19417; AEM19417; BS1330_I2104.
GeneIDi1167813.
12137893.
KEGGibms:BR2110.
bsi:BS1330_I2104.
PATRICi17792653. VBIBruSui107850_2147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31000.1 .
CP002997 Genomic DNA. Translation: AEM19417.1 .
RefSeqi NP_699085.1. NC_004310.3.
YP_005616909.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FXY4.
SMRi Q8FXY4. Positions 20-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR2110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN31000 ; AAN31000 ; BR2110 .
AEM19417 ; AEM19417 ; BS1330_I2104 .
GeneIDi 1167813.
12137893.
KEGGi bms:BR2110.
bsi:BS1330_I2104.
PATRICi 17792653. VBIBruSui107850_2147.

Phylogenomic databases

eggNOGi COG0133.
HOGENOMi HOG000161710.
KOi K01696.
OMAi EFMTLLQ.
OrthoDBi EOG6GFGH7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .

Miscellaneous databases

PROi Q8FXY4.

Family and domain databases

HAMAPi MF_00133. Trp_synth_beta.
InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view ]
PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00263. trpB. 1 hit.
PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiTRPB_BRUSU
AccessioniPrimary (citable) accession number: Q8FXY4
Secondary accession number(s): G0K958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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