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Q8FXY4 (TRPB_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase beta chain

EC=4.2.1.20
Gene names
Name:trpB
Ordered Locus Names:BR2110, BS1330_I2104
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine By similarity. HAMAP-Rule MF_00133

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00133

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00133

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00133

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   LigandPyridoxal phosphate
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Tryptophan synthase beta chain HAMAP-Rule MF_00133
PRO_0000098925

Amino acid modifications

Modified residue991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FXY4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5DC87B86C3CDFFA1

FASTA40643,571
        10         20         30         40         50         60 
MNKPVAPNSY KTGPDEEGMF GIFGGRFVAE TLMPLILELQ QAYETAKNDP EFKAELNALS 

        70         80         90        100        110        120 
TFYAGRPSKL YYAEGLSKHL GGAKIYFKRE DLNHTGSHKI NNCLGQILLA KRMGKTRIIA 

       130        140        150        160        170        180 
ETGAGQHGVA SATVAARFGL PCIVYMGATD VERQKPNVFR MKLLGAEVKP VSAGNGTLKD 

       190        200        210        220        230        240 
AMNEALRDWV TNVEDTYYLI GTAAGPHPYP ELVRDFQSVI GTEARQQILE QEGRLPDVIV 

       250        260        270        280        290        300 
AAVGGGSNAI GLFHPFLDDA SVKIVGVEAG GRGLEGEEHC ASMSAGRPGV LHGNRTYLLQ 

       310        320        330        340        350        360 
NADGQILEGH SVSAGLDYPG VGPEHSWLKD SGRVDYVPIL DNEALDAFQL CTRTEGIIPA 

       370        380        390        400 
LESAHAIAQA VKMAPTMGKD KVMIVNLSGR GDKDVHTVGK LLGMDI 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN31000.1.
CP002997 Genomic DNA. Translation: AEM19417.1.
RefSeqNP_699085.1. NC_004310.3.
YP_005616909.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8FXY4.
SMRQ8FXY4. Positions 20-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR2110.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN31000; AAN31000; BR2110.
AEM19417; AEM19417; BS1330_I2104.
GeneID1167813.
12137893.
KEGGbms:BR2110.
bsi:BS1330_I2104.
PATRIC17792653. VBIBruSui107850_2147.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0133.
HOGENOMHOG000161710.
KOK01696.
OMAIGRAEYV.
OrthoDBEOG6GFGH7.
ProtClustDBPRK04346.

Enzyme and pathway databases

UniPathwayUPA00035; UER00044.

Family and domain databases

HAMAPMF_00133. Trp_synth_beta.
InterProIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
[Graphical view]
PANTHERPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamPF00291. PALP. 1 hit.
[Graphical view]
PIRSFPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMSSF53686. SSF53686. 1 hit.
TIGRFAMsTIGR00263. trpB. 1 hit.
PROSITEPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8FXY4.

Entry information

Entry nameTRPB_BRUSU
AccessionPrimary (citable) accession number: Q8FXY4
Secondary accession number(s): G0K958
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names