Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8FXY4

- TRPB_BRUSU

UniProt

Q8FXY4 - TRPB_BRUSU

Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

    Catalytic activityi

    L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. tryptophan synthase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
    Gene namesi
    Name:trpBUniRule annotation
    Ordered Locus Names:BR2110, BS1330_I2104
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Tryptophan synthase beta chainPRO_0000098925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR2110.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FXY4.
    SMRiQ8FXY4. Positions 20-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0133.
    HOGENOMiHOG000161710.
    KOiK01696.
    OMAiEFMTLLQ.
    OrthoDBiEOG6GFGH7.

    Family and domain databases

    HAMAPiMF_00133. Trp_synth_beta.
    InterProiIPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view]
    PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
    PfamiPF00291. PALP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMiSSF53686. SSF53686. 1 hit.
    TIGRFAMsiTIGR00263. trpB. 1 hit.
    PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FXY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKPVAPNSY KTGPDEEGMF GIFGGRFVAE TLMPLILELQ QAYETAKNDP    50
    EFKAELNALS TFYAGRPSKL YYAEGLSKHL GGAKIYFKRE DLNHTGSHKI 100
    NNCLGQILLA KRMGKTRIIA ETGAGQHGVA SATVAARFGL PCIVYMGATD 150
    VERQKPNVFR MKLLGAEVKP VSAGNGTLKD AMNEALRDWV TNVEDTYYLI 200
    GTAAGPHPYP ELVRDFQSVI GTEARQQILE QEGRLPDVIV AAVGGGSNAI 250
    GLFHPFLDDA SVKIVGVEAG GRGLEGEEHC ASMSAGRPGV LHGNRTYLLQ 300
    NADGQILEGH SVSAGLDYPG VGPEHSWLKD SGRVDYVPIL DNEALDAFQL 350
    CTRTEGIIPA LESAHAIAQA VKMAPTMGKD KVMIVNLSGR GDKDVHTVGK 400
    LLGMDI 406
    Length:406
    Mass (Da):43,571
    Last modified:March 1, 2003 - v1
    Checksum:i5DC87B86C3CDFFA1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN31000.1.
    CP002997 Genomic DNA. Translation: AEM19417.1.
    RefSeqiNP_699085.1. NC_004310.3.
    YP_005616909.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN31000; AAN31000; BR2110.
    AEM19417; AEM19417; BS1330_I2104.
    GeneIDi1167813.
    12137893.
    KEGGibms:BR2110.
    bsi:BS1330_I2104.
    PATRICi17792653. VBIBruSui107850_2147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN31000.1 .
    CP002997 Genomic DNA. Translation: AEM19417.1 .
    RefSeqi NP_699085.1. NC_004310.3.
    YP_005616909.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8FXY4.
    SMRi Q8FXY4. Positions 20-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR2110.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN31000 ; AAN31000 ; BR2110 .
    AEM19417 ; AEM19417 ; BS1330_I2104 .
    GeneIDi 1167813.
    12137893.
    KEGGi bms:BR2110.
    bsi:BS1330_I2104.
    PATRICi 17792653. VBIBruSui107850_2147.

    Phylogenomic databases

    eggNOGi COG0133.
    HOGENOMi HOG000161710.
    KOi K01696.
    OMAi EFMTLLQ.
    OrthoDBi EOG6GFGH7.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .

    Miscellaneous databases

    PROi Q8FXY4.

    Family and domain databases

    HAMAPi MF_00133. Trp_synth_beta.
    InterProi IPR001926. Trp_syn_b_sub_like_PLP_eny_SF.
    IPR006653. Trp_synth_b_CS.
    IPR006654. Trp_synth_beta.
    IPR023026. Trp_synth_beta/beta-like.
    [Graphical view ]
    PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
    Pfami PF00291. PALP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
    SUPFAMi SSF53686. SSF53686. 1 hit.
    TIGRFAMsi TIGR00263. trpB. 1 hit.
    PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiTRPB_BRUSU
    AccessioniPrimary (citable) accession number: Q8FXY4
    Secondary accession number(s): G0K958
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3