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Q8FXY4

- TRPB_BRUSU

UniProt

Q8FXY4 - TRPB_BRUSU

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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:BR2110, BS1330_I2104
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Tryptophan synthase beta chainPRO_0000098925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR2110.

Structurei

3D structure databases

ProteinModelPortaliQ8FXY4.
SMRiQ8FXY4. Positions 20-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0133.
HOGENOMiHOG000161710.
KOiK01696.
OMAiEFMTLLQ.
OrthoDBiEOG6GFGH7.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta.
InterProiIPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF3. PTHR10314:SF3. 1 hit.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR00263. trpB. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FXY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKPVAPNSY KTGPDEEGMF GIFGGRFVAE TLMPLILELQ QAYETAKNDP
60 70 80 90 100
EFKAELNALS TFYAGRPSKL YYAEGLSKHL GGAKIYFKRE DLNHTGSHKI
110 120 130 140 150
NNCLGQILLA KRMGKTRIIA ETGAGQHGVA SATVAARFGL PCIVYMGATD
160 170 180 190 200
VERQKPNVFR MKLLGAEVKP VSAGNGTLKD AMNEALRDWV TNVEDTYYLI
210 220 230 240 250
GTAAGPHPYP ELVRDFQSVI GTEARQQILE QEGRLPDVIV AAVGGGSNAI
260 270 280 290 300
GLFHPFLDDA SVKIVGVEAG GRGLEGEEHC ASMSAGRPGV LHGNRTYLLQ
310 320 330 340 350
NADGQILEGH SVSAGLDYPG VGPEHSWLKD SGRVDYVPIL DNEALDAFQL
360 370 380 390 400
CTRTEGIIPA LESAHAIAQA VKMAPTMGKD KVMIVNLSGR GDKDVHTVGK

LLGMDI
Length:406
Mass (Da):43,571
Last modified:March 1, 2003 - v1
Checksum:i5DC87B86C3CDFFA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31000.1.
CP002997 Genomic DNA. Translation: AEM19417.1.
RefSeqiNP_699085.1. NC_004310.3.
YP_005616909.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN31000; AAN31000; BR2110.
AEM19417; AEM19417; BS1330_I2104.
GeneIDi1167813.
12137893.
KEGGibms:BR2110.
bsi:BS1330_I2104.
PATRICi17792653. VBIBruSui107850_2147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31000.1 .
CP002997 Genomic DNA. Translation: AEM19417.1 .
RefSeqi NP_699085.1. NC_004310.3.
YP_005616909.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FXY4.
SMRi Q8FXY4. Positions 20-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR2110.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN31000 ; AAN31000 ; BR2110 .
AEM19417 ; AEM19417 ; BS1330_I2104 .
GeneIDi 1167813.
12137893.
KEGGi bms:BR2110.
bsi:BS1330_I2104.
PATRICi 17792653. VBIBruSui107850_2147.

Phylogenomic databases

eggNOGi COG0133.
HOGENOMi HOG000161710.
KOi K01696.
OMAi EFMTLLQ.
OrthoDBi EOG6GFGH7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00044 .

Miscellaneous databases

PROi Q8FXY4.

Family and domain databases

HAMAPi MF_00133. Trp_synth_beta.
InterProi IPR006653. Trp_synth_b_CS.
IPR006654. Trp_synth_beta.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view ]
PANTHERi PTHR10314:SF3. PTHR10314:SF3. 1 hit.
Pfami PF00291. PALP. 1 hit.
[Graphical view ]
PIRSFi PIRSF001413. Trp_syn_beta. 1 hit.
SUPFAMi SSF53686. SSF53686. 1 hit.
TIGRFAMsi TIGR00263. trpB. 1 hit.
PROSITEi PS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiTRPB_BRUSU
AccessioniPrimary (citable) accession number: Q8FXY4
Secondary accession number(s): G0K958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3