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Q8FXX5

- SYFA_BRUSU

UniProt

Q8FXX5 - SYFA_BRUSU

Protein

Phenylalanine--tRNA ligase alpha subunit

Gene

pheS

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

    Cofactori

    Binds 2 magnesium ions per tetramer.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi269 – 2691MagnesiumUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
    4. tRNA binding Source: InterPro

    GO - Biological processi

    1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phenylalanine--tRNA ligase alpha subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
    Alternative name(s):
    Phenylalanyl-tRNA synthetase alpha subunitUniRule annotation
    Short name:
    PheRSUniRule annotation
    Gene namesi
    Name:pheSUniRule annotation
    Ordered Locus Names:BR2122, BS1330_I2116
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Phenylalanine--tRNA ligase alpha subunitPRO_0000126675Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR2122.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FXX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0016.
    HOGENOMiHOG000242675.
    KOiK01889.
    OMAiQIRTMEH.
    OrthoDBiEOG6WX4QN.

    Family and domain databases

    HAMAPiMF_00281. Phe_tRNA_synth_alpha1.
    InterProiIPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view]
    PfamiPF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view]
    SUPFAMiSSF46589. SSF46589. 1 hit.
    TIGRFAMsiTIGR00468. pheS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FXX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDLEQLERQ ILEDIAAAVD EQGIEAVRVA ALGKKGTVSE KLKTLGGMSP    50
    EERQMQGPAI NGLKNRVTEA LSERRTELRK AAVAARLERE KVDVTLPVRE 100
    SAASRGRIHP ISQVIDEITA IFADMGFSIA EGPDIETDYY NFTALNFPEG 150
    HPAREMHDTF FFNPDEKGER KLLRTHTSPV QVHTMEKFAA MRDKEGRDEP 200
    IRIVIPGKTY RMDSDATHSP MFHQVEGLVV DKSANVANMK WVLEEFCKAF 250
    FEVPSVKMRM RPSFFPFTEP SVEVDIQCDR SGPHVKFGEG NDWLEILGCG 300
    MVHPNVLRMS GYDPEVYQGF AWGMGIDRIA MLKYGMPDLR AFFDADVRWI 350
    EHYGFRPLDI PTLFGGLSA 369
    Length:369
    Mass (Da):41,598
    Last modified:March 1, 2003 - v1
    Checksum:iBC2B822DB0270926
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN31012.1.
    CP002997 Genomic DNA. Translation: AEM19429.1.
    RefSeqiNP_699097.1. NC_004310.3.
    YP_005616921.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN31012; AAN31012; BR2122.
    AEM19429; AEM19429; BS1330_I2116.
    GeneIDi1167825.
    12137905.
    KEGGibms:BR2122.
    bsi:BS1330_I2116.
    PATRICi17792679. VBIBruSui107850_2160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN31012.1 .
    CP002997 Genomic DNA. Translation: AEM19429.1 .
    RefSeqi NP_699097.1. NC_004310.3.
    YP_005616921.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8FXX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR2122.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN31012 ; AAN31012 ; BR2122 .
    AEM19429 ; AEM19429 ; BS1330_I2116 .
    GeneIDi 1167825.
    12137905.
    KEGGi bms:BR2122.
    bsi:BS1330_I2116.
    PATRICi 17792679. VBIBruSui107850_2160.

    Phylogenomic databases

    eggNOGi COG0016.
    HOGENOMi HOG000242675.
    KOi K01889.
    OMAi QIRTMEH.
    OrthoDBi EOG6WX4QN.

    Family and domain databases

    HAMAPi MF_00281. Phe_tRNA_synth_alpha1.
    InterProi IPR006195. aa-tRNA-synth_II.
    IPR004529. Phe-tRNA-synth_IIc_asu.
    IPR004188. Phe-tRNA_ligase_II_N.
    IPR022911. Phe_tRNA_ligase_alpha1_bac.
    IPR002319. Phenylalanyl-tRNA_Synthase.
    IPR010978. tRNA-bd_arm.
    [Graphical view ]
    Pfami PF02912. Phe_tRNA-synt_N. 1 hit.
    PF01409. tRNA-synt_2d. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46589. SSF46589. 1 hit.
    TIGRFAMsi TIGR00468. pheS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiSYFA_BRUSU
    AccessioniPrimary (citable) accession number: Q8FXX5
    Secondary accession number(s): G0K970
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3