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Q8FXX4

- SYFB_BRUSU

UniProt

Q8FXX4 - SYFB_BRUSU

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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per tetramer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi454 – 4541MagnesiumUniRule annotation
Metal bindingi460 – 4601Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi463 – 4631MagnesiumUniRule annotation
Metal bindingi464 – 4641MagnesiumUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. phenylalanine-tRNA ligase activity Source: UniProtKB-HAMAP
  4. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. phenylalanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
  2. tRNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, RNA-binding, tRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Short name:
PheRSUniRule annotation
Gene namesi
Name:pheTUniRule annotation
Ordered Locus Names:BR2123, BS1330_I2117
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Phenylalanine--tRNA ligase beta subunitPRO_0000126855Add
BLAST

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR2123.

Structurei

3D structure databases

ProteinModelPortaliQ8FXX4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 148111tRNA-bindingUniRule annotationAdd
BLAST
Domaini401 – 47676B5UniRule annotationAdd
BLAST
Domaini710 – 80394FDX-ACBUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotation
Contains 1 B5 domain.UniRule annotation
Contains 1 FDX-ACB domain.UniRule annotation
Contains 1 tRNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0073.
HOGENOMiHOG000292085.
KOiK01890.
OMAiRTSCDET.
OrthoDBiEOG6CCH1J.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPiMF_00283. Phe_tRNA_synth_beta1.
InterProiIPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view]
PfamiPF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view]
SMARTiSM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsiTIGR00472. pheT_bact. 1 hit.
PROSITEiPS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FXX4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFTLSWLKD HLETDATLDE IVEKLTDIGL EVESVDDRAA FRAFTIARVL
60 70 80 90 100
TATRHPDADK LQVLSVDTGD GKPVQVVCGA PNARAGLVGV LGRPGDYVPG
110 120 130 140 150
LDVTLSVGKI RGVESFGMMC SERELELSDE HNGIIDLAEN APVGTSFAAY
160 170 180 190 200
MGLDDPIIEI GLTPNRADCT GIRGIARDLA AAGLGTLKNT LPDAVKGEGE
210 220 230 240 250
TPVKVILDQD AGNPFCTGFA LRMVKGVKNG PSPKWMQQRL KAIGLRPINA
260 270 280 290 300
LVDITNYVTF DQGRPLHVFD AAKVKGNLTV RTARDGETIL ALDQREYKLN
310 320 330 340 350
AGMYVIADEN GPESIAGIMG GEHSGCDENT VDVLIESALW DPRMIARTGR
360 370 380 390 400
ELGIVTDARY RFERGVDPEM MVPGAEIATK LVLELCGGQP TVLDVVGYKP
410 420 430 440 450
HTARVIDFPV TEVKRLTGLD VSYEDAFDIL KRLGFGVEGD GKTIRATVPS
460 470 480 490 500
WRGDVEGKAD LVEEVMRIHG INRIDPQPLP SHGAVNGRIL TTLQIRTRHA
510 520 530 540 550
RRMLASRGMM EAVTYSFISE AQAKAFGGGK PELKLANPIA ADMSDMRPSL
560 570 580 590 600
LPGLLAAAQR NADRGFGDIA LFEVSGIYEG DTPDKQRRVA GGVRRGTAKV
610 620 630 640 650
EGAGRFWAGN AAPVGVFDAK ADALAALEAA GAPVDRIQIE AGGPEWLHPG
660 670 680 690 700
RSGTLKLGPK VVLGTFGEFH PDTLEALDVS GALCGFEVYL DAIPEPKAKS
710 720 730 740 750
ARTKPALSLS LFQSLKRDYA FVVDAAVEAG NVVKAVSSAD KKLIVGVQVF
760 770 780 790 800
DIFTGASLGE GKKSIAVEVL LQPQDRTLTD EDLEALSKQI VASVAKQTGG

VLRG
Length:804
Mass (Da):85,849
Last modified:March 1, 2003 - v1
Checksum:i66E5F7F8268E875D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN31013.1.
CP002997 Genomic DNA. Translation: AEM19430.1.
RefSeqiNP_699098.1. NC_004310.3.
YP_005616922.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN31013; AAN31013; BR2123.
AEM19430; AEM19430; BS1330_I2117.
GeneIDi1167826.
12137906.
KEGGibms:BR2123.
bsi:BS1330_I2117.
PATRICi17792681. VBIBruSui107850_2161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN31013.1 .
CP002997 Genomic DNA. Translation: AEM19430.1 .
RefSeqi NP_699098.1. NC_004310.3.
YP_005616922.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FXX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR2123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN31013 ; AAN31013 ; BR2123 .
AEM19430 ; AEM19430 ; BS1330_I2117 .
GeneIDi 1167826.
12137906.
KEGGi bms:BR2123.
bsi:BS1330_I2117.
PATRICi 17792681. VBIBruSui107850_2161.

Phylogenomic databases

eggNOGi COG0073.
HOGENOMi HOG000292085.
KOi K01890.
OMAi RTSCDET.
OrthoDBi EOG6CCH1J.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.30.56.20. 1 hit.
3.30.70.380. 1 hit.
3.50.40.10. 1 hit.
HAMAPi MF_00283. Phe_tRNA_synth_beta1.
InterProi IPR005146. B3/B4_tRNA-bd.
IPR009061. DNA-bd_dom_put.
IPR012340. NA-bd_OB-fold.
IPR004532. Phe-tRNA-ligase_IIc_bsu.
IPR020825. Phe-tRNA_synthase_B3/B4.
IPR005121. PheS_beta_Fdx_antiC-bd.
IPR002547. tRNA-bd_dom.
IPR005147. tRNA_synthase_B5-dom.
[Graphical view ]
Pfami PF03483. B3_4. 1 hit.
PF03484. B5. 1 hit.
PF03147. FDX-ACB. 1 hit.
PF01588. tRNA_bind. 1 hit.
[Graphical view ]
SMARTi SM00873. B3_4. 1 hit.
SM00874. B5. 1 hit.
SM00896. FDX-ACB. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54991. SSF54991. 1 hit.
SSF56037. SSF56037. 1 hit.
TIGRFAMsi TIGR00472. pheT_bact. 1 hit.
PROSITEi PS51483. B5. 1 hit.
PS51447. FDX_ACB. 1 hit.
PS50886. TRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiSYFB_BRUSU
AccessioniPrimary (citable) accession number: Q8FXX4
Secondary accession number(s): G0K971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3