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Q8FXW9

- PYRF_BRUSU

UniProt

Q8FXW9 - PYRF_BRUSU

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, BR2128, BS1330_I2122
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity.UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei18 – 181Substrate By similarity
Binding sitei40 – 401Substrate By similarity
Active sitei69 – 691Proton donor By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei183 – 1831Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei213 – 2131Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:BR2128, BS1330_I2122
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000134531Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR2128.

Structurei

3D structure databases

ProteinModelPortaliQ8FXW9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 7610Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226070.
KOiK01591.
OMAiSAYHAIK.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FXW9-1 [UniParc]FASTAAdd to Basket

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MTTELHDDAS GRLIVGLDVP TIAEAEKVVE ELGNAVSFYK IGYQLVFAGG    50
LDFAKSLVAA RKKVFLDMKL LDIDNTIAKG VENVAKMGVS MLTLHAYPKA 100
MRAAVEAARG SDLCLLGVTV LTSMDNADLR EAGYSDNAET LVLKRARQAH 150
EAGMGGIVAS AVEAQAIRQA VGPDMAIVTP GIRPAGSEKG DQKRVMTPAD 200
ALRAGASHLV VARPIVGAPD RKAAALAILK EMRSIGRS 238
Length:238
Mass (Da):25,020
Last modified:March 1, 2003 - v1
Checksum:iCBD7B7515095AD4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31018.1.
CP002997 Genomic DNA. Translation: AEM19435.1.
RefSeqiNP_699103.1. NC_004310.3.
YP_005616927.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN31018; AAN31018; BR2128.
AEM19435; AEM19435; BS1330_I2122.
GeneIDi1167831.
12137911.
KEGGibms:BR2128.
bsi:BS1330_I2122.
PATRICi17792691. VBIBruSui107850_2166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31018.1 .
CP002997 Genomic DNA. Translation: AEM19435.1 .
RefSeqi NP_699103.1. NC_004310.3.
YP_005616927.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FXW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR2128.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN31018 ; AAN31018 ; BR2128 .
AEM19435 ; AEM19435 ; BS1330_I2122 .
GeneIDi 1167831.
12137911.
KEGGi bms:BR2128.
bsi:BS1330_I2122.
PATRICi 17792691. VBIBruSui107850_2166.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226070.
KOi K01591.
OMAi SAYHAIK.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiPYRF_BRUSU
AccessioniPrimary (citable) accession number: Q8FXW9
Secondary accession number(s): G0K976
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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