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Q8FXT6

- TRMB_BRUSU

UniProt

Q8FXT6 - TRMB_BRUSU

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641S-adenosyl-L-methionineUniRule annotation
Binding sitei89 – 891S-adenosyl-L-methionineUniRule annotation
Binding sitei116 – 1161S-adenosyl-L-methionineUniRule annotation
Active sitei138 – 1381By similarity
Binding sitei138 – 1381S-adenosyl-L-methionineUniRule annotation
Binding sitei142 – 1421SubstrateUniRule annotation
Binding sitei174 – 1741SubstrateUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:BR2161, BS1330_I2155
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233tRNA (guanine-N(7)-)-methyltransferasePRO_0000171306Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR2161.

Structurei

3D structure databases

ProteinModelPortaliQ8FXT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 2154Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073969.
KOiK03439.
OMAiRAFYGRR.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FXT6 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MIDENHPMRA AGNFFGRRHG KPLRPHQSNL FEDLLPRLKL DLATPASQDL
60 70 80 90 100
RSLFEAPVET VRMEIGFGGG EHLHHESGRY PQSGFIGVEP FINGMAKMLA
110 120 130 140 150
ALDQAPRPNL RLYDEDATAV LDWLPDASLA GIDLFYPDPW HKRRHWKRRF
160 170 180 190 200
VSDANLDRFA RVLKPGAKFR FASDIEHYVN WTLQHCRRHA AFDWQAESPA
210 220 230
DWNDAYEGWP GTRYEAKAFR EGRRAVYLTF IRR
Length:233
Mass (Da):27,024
Last modified:March 1, 2003 - v1
Checksum:i87BB319216B97E03
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31051.1.
CP002997 Genomic DNA. Translation: AEM19468.1.
RefSeqiNP_699136.1. NC_004310.3.
YP_005616960.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN31051; AAN31051; BR2161.
AEM19468; AEM19468; BS1330_I2155.
GeneIDi1167864.
12138584.
KEGGibms:BR2161.
bsi:BS1330_I2155.
PATRICi17792755. VBIBruSui107850_2198.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN31051.1 .
CP002997 Genomic DNA. Translation: AEM19468.1 .
RefSeqi NP_699136.1. NC_004310.3.
YP_005616960.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FXT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR2161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN31051 ; AAN31051 ; BR2161 .
AEM19468 ; AEM19468 ; BS1330_I2155 .
GeneIDi 1167864.
12138584.
KEGGi bms:BR2161.
bsi:BS1330_I2155.
PATRICi 17792755. VBIBruSui107850_2198.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073969.
KOi K03439.
OMAi RAFYGRR.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiTRMB_BRUSU
AccessioniPrimary (citable) accession number: Q8FXT6
Secondary accession number(s): G0K9I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3