Q8FXM5 (MGTC_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MgtC

Gene names

Name:	mgtC
Ordered Locus Names:	BRA0040, BS1330_II0040

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Virulence factor required for growth in low Mg2+ medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na+/K+-ATPase By similarity. Ref.3
Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the MgtC/SapB family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Protein MgtC		PRO_0000250526
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	38 – 58	21	Helical; Potential
	Transmembrane	66 – 86	21	Helical; Potential
	Transmembrane	105 – 125	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8FXM5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 2D1E20FA7069CE60	FASTA	238	25,357
	10 20 30 40 50 60 MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV VFSSLVSGDS 70 80 90 100 110 120 SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS AAVGVLCGAG LISHAAVATV 130 140 150 160 170 180 FIIAVNALLR PLVQVLEFQA MRRGAFQPTY AIDIICHGDA EAQVRALLLR DIGDHLHIHE 190 200 210 220 230 LESSNIEGTN RVEVSATVRA DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.
[2]	"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.
[3]	"Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment." Lavigne J.-P., O'Callaghan D., Blanc-Potard A.-B. Infect. Immun. 73:3160-3163(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014292 Genomic DNA. Translation: AAN33252.1. CP002998 Genomic DNA. Translation: AEM19532.1.
RefSeq	NP_699247.1. NC_004311.2. YP_005613758.1. NC_017250.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BRA0040.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN33252; AAN33252; BRA0040. AEM19532; AEM19532; BS1330_II0040.
GeneID	1164476. 12139464.
KEGG	bms:BRA0040. bsi:BS1330_II0040.
PATRIC	17792885. VBIBruSui107850_2262.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1285.
HOGENOM	HOG000080251.
KO	K07507.
OMA	HIRFLLM.
ProtClustDB	CLSK898661.
Family and domain databases
InterPro	IPR003416. MgtCSapBSrpB_transpt. [Graphical view]
Pfam	PF02308. MgtC. 1 hit. [Graphical view]
PRINTS	PR01837. MGTCSAPBPROT.
ProtoNet	Search...

Entry information

Entry name

MGTC_BRUSU

Accession

Primary (citable) accession number: Q8FXM5
Secondary accession number(s): G0KEN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program