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Q8FXM5

- MGTC_BRUSU

UniProt

Q8FXM5 - MGTC_BRUSU

Protein

Protein MgtC

Gene

mgtC

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Virulence factor required for growth in low Mg2+ medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na+/K+-ATPase By similarity.By similarity

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW

    Keywords - Biological processi

    Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MgtC
    Gene namesi
    Name:mgtC
    Ordered Locus Names:BRA0040, BS1330_II0040
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Protein MgtCPRO_0000250526Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BRA0040.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MgtC/SapB family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1285.
    HOGENOMiHOG000080251.
    KOiK07507.
    OMAiPGQLEVC.
    OrthoDBiEOG6H4KB4.

    Family and domain databases

    InterProiIPR003416. MgtCSapBSrpB_transpt.
    [Graphical view]
    PfamiPF02308. MgtC. 1 hit.
    [Graphical view]
    PRINTSiPR01837. MGTCSAPBPROT.

    Sequencei

    Sequence statusi: Complete.

    Q8FXM5-1 [UniParc]FASTAAdd to Basket

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    MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV    50
    VFSSLVSGDS SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS 100
    AAVGVLCGAG LISHAAVATV FIIAVNALLR PLVQVLEFQA MRRGAFQPTY 150
    AIDIICHGDA EAQVRALLLR DIGDHLHIHE LESSNIEGTN RVEVSATVRA 200
    DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL 238
    Length:238
    Mass (Da):25,357
    Last modified:March 1, 2003 - v1
    Checksum:i2D1E20FA7069CE60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33252.1.
    CP002998 Genomic DNA. Translation: AEM19532.1.
    RefSeqiNP_699247.1. NC_004311.2.
    YP_005613758.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN33252; AAN33252; BRA0040.
    AEM19532; AEM19532; BS1330_II0040.
    GeneIDi1164476.
    12139464.
    KEGGibms:BRA0040.
    bsi:BS1330_II0040.
    PATRICi17792885. VBIBruSui107850_2262.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33252.1 .
    CP002998 Genomic DNA. Translation: AEM19532.1 .
    RefSeqi NP_699247.1. NC_004311.2.
    YP_005613758.1. NC_017250.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA0040.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN33252 ; AAN33252 ; BRA0040 .
    AEM19532 ; AEM19532 ; BS1330_II0040 .
    GeneIDi 1164476.
    12139464.
    KEGGi bms:BRA0040.
    bsi:BS1330_II0040.
    PATRICi 17792885. VBIBruSui107850_2262.

    Phylogenomic databases

    eggNOGi COG1285.
    HOGENOMi HOG000080251.
    KOi K07507.
    OMAi PGQLEVC.
    OrthoDBi EOG6H4KB4.

    Family and domain databases

    InterProi IPR003416. MgtCSapBSrpB_transpt.
    [Graphical view ]
    Pfami PF02308. MgtC. 1 hit.
    [Graphical view ]
    PRINTSi PR01837. MGTCSAPBPROT.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    3. "Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment."
      Lavigne J.-P., O'Callaghan D., Blanc-Potard A.-B.
      Infect. Immun. 73:3160-3163(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: 1330.

    Entry informationi

    Entry nameiMGTC_BRUSU
    AccessioniPrimary (citable) accession number: Q8FXM5
    Secondary accession number(s): G0KEN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3