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Q8FXM5 (MGTC_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein MgtC
Gene names
Name:mgtC
Ordered Locus Names:BRA0040, BS1330_II0040
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Virulence factor required for growth in low Mg2+ medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na+/K+-ATPase By similarity. Ref.3

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the MgtC/SapB family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Protein MgtC
PRO_0000250526

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane105 – 12521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8FXM5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2D1E20FA7069CE60

FASTA23825,357
        10         20         30         40         50         60 
MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV VFSSLVSGDS 

        70         80         90        100        110        120 
SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS AAVGVLCGAG LISHAAVATV 

       130        140        150        160        170        180 
FIIAVNALLR PLVQVLEFQA MRRGAFQPTY AIDIICHGDA EAQVRALLLR DIGDHLHIHE 

       190        200        210        220        230 
LESSNIEGTN RVEVSATVRA DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL 

« Hide

References

« Hide 'large scale' references
[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment."
Lavigne J.-P., O'Callaghan D., Blanc-Potard A.-B.
Infect. Immun. 73:3160-3163(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014292 Genomic DNA. Translation: AAN33252.1.
CP002998 Genomic DNA. Translation: AEM19532.1.
RefSeqNP_699247.1. NC_004311.2.
YP_005613758.1. NC_017250.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BRA0040.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN33252; AAN33252; BRA0040.
AEM19532; AEM19532; BS1330_II0040.
GeneID1164476.
12139464.
KEGGbms:BRA0040.
bsi:BS1330_II0040.
PATRIC17792885. VBIBruSui107850_2262.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1285.
HOGENOMHOG000080251.
KOK07507.
OMAHIRFLLM.
OrthoDBEOG6H4KB4.
ProtClustDBCLSK898661.

Family and domain databases

InterProIPR003416. MgtCSapBSrpB_transpt.
[Graphical view]
PfamPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSPR01837. MGTCSAPBPROT.
ProtoNetSearch...

Entry information

Entry nameMGTC_BRUSU
AccessionPrimary (citable) accession number: Q8FXM5
Secondary accession number(s): G0KEN8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names