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Q8FXM5

- MGTC_BRUSU

UniProt

Q8FXM5 - MGTC_BRUSU

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Protein

Protein MgtC

Gene

mgtC

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Virulence factor required for growth in low Mg2+ medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na+/K+-ATPase (By similarity).By similarity

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MgtC
Gene namesi
Name:mgtC
Ordered Locus Names:BRA0040, BS1330_II0040
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Protein MgtCPRO_0000250526Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BRA0040.

Family & Domainsi

Sequence similaritiesi

Belongs to the MgtC/SapB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1285.
HOGENOMiHOG000080251.
KOiK07507.
OMAiPGQLEVC.
OrthoDBiEOG6H4KB4.

Family and domain databases

InterProiIPR003416. MgtCSapBSrpB_transpt.
[Graphical view]
PfamiPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSiPR01837. MGTCSAPBPROT.

Sequencei

Sequence statusi: Complete.

Q8FXM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV
60 70 80 90 100
VFSSLVSGDS SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS
110 120 130 140 150
AAVGVLCGAG LISHAAVATV FIIAVNALLR PLVQVLEFQA MRRGAFQPTY
160 170 180 190 200
AIDIICHGDA EAQVRALLLR DIGDHLHIHE LESSNIEGTN RVEVSATVRA
210 220 230
DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL
Length:238
Mass (Da):25,357
Last modified:March 1, 2003 - v1
Checksum:i2D1E20FA7069CE60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33252.1.
CP002998 Genomic DNA. Translation: AEM19532.1.
RefSeqiNP_699247.1. NC_004311.2.
YP_005613758.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33252; AAN33252; BRA0040.
AEM19532; AEM19532; BS1330_II0040.
GeneIDi1164476.
12139464.
KEGGibms:BRA0040.
bsi:BS1330_II0040.
PATRICi17792885. VBIBruSui107850_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33252.1 .
CP002998 Genomic DNA. Translation: AEM19532.1 .
RefSeqi NP_699247.1. NC_004311.2.
YP_005613758.1. NC_017250.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BRA0040.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN33252 ; AAN33252 ; BRA0040 .
AEM19532 ; AEM19532 ; BS1330_II0040 .
GeneIDi 1164476.
12139464.
KEGGi bms:BRA0040.
bsi:BS1330_II0040.
PATRICi 17792885. VBIBruSui107850_2262.

Phylogenomic databases

eggNOGi COG1285.
HOGENOMi HOG000080251.
KOi K07507.
OMAi PGQLEVC.
OrthoDBi EOG6H4KB4.

Family and domain databases

InterProi IPR003416. MgtCSapBSrpB_transpt.
[Graphical view ]
Pfami PF02308. MgtC. 1 hit.
[Graphical view ]
PRINTSi PR01837. MGTCSAPBPROT.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment."
    Lavigne J.-P., O'Callaghan D., Blanc-Potard A.-B.
    Infect. Immun. 73:3160-3163(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 1330.

Entry informationi

Entry nameiMGTC_BRUSU
AccessioniPrimary (citable) accession number: Q8FXM5
Secondary accession number(s): G0KEN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3