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Protein

Protein MgtC

Gene

mgtC

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Virulence factor required for growth in low Mg2+ medium and for intramacrophage survival. May be involved in regulating membrane potential by activating Na+/K+-ATPase (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MgtC
Gene namesi
Name:mgtC
Ordered Locus Names:BRA0040, BS1330_II0040
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Protein MgtCPRO_0000250526Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the MgtC/SapB family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1285.
HOGENOMiHOG000080251.
KOiK07507.
OMAiVITARWR.
OrthoDBiEOG6H4KB4.

Family and domain databases

InterProiIPR003416. MgtCSapBSrpB_transpt.
[Graphical view]
PfamiPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSiPR01837. MGTCSAPBPROT.

Sequencei

Sequence statusi: Complete.

Q8FXM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV
60 70 80 90 100
VFSSLVSGDS SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS
110 120 130 140 150
AAVGVLCGAG LISHAAVATV FIIAVNALLR PLVQVLEFQA MRRGAFQPTY
160 170 180 190 200
AIDIICHGDA EAQVRALLLR DIGDHLHIHE LESSNIEGTN RVEVSATVRA
210 220 230
DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL
Length:238
Mass (Da):25,357
Last modified:March 1, 2003 - v1
Checksum:i2D1E20FA7069CE60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33252.1.
CP002998 Genomic DNA. Translation: AEM19532.1.
RefSeqiWP_002966539.1. NZ_KN046805.1.

Genome annotation databases

EnsemblBacteriaiAAN33252; AAN33252; BRA0040.
AEM19532; AEM19532; BS1330_II0040.
GeneIDi3827761.
KEGGibms:BRA0040.
bsi:BS1330_II0040.
PATRICi17792885. VBIBruSui107850_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33252.1.
CP002998 Genomic DNA. Translation: AEM19532.1.
RefSeqiWP_002966539.1. NZ_KN046805.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33252; AAN33252; BRA0040.
AEM19532; AEM19532; BS1330_II0040.
GeneIDi3827761.
KEGGibms:BRA0040.
bsi:BS1330_II0040.
PATRICi17792885. VBIBruSui107850_2262.

Phylogenomic databases

eggNOGiCOG1285.
HOGENOMiHOG000080251.
KOiK07507.
OMAiVITARWR.
OrthoDBiEOG6H4KB4.

Family and domain databases

InterProiIPR003416. MgtCSapBSrpB_transpt.
[Graphical view]
PfamiPF02308. MgtC. 1 hit.
[Graphical view]
PRINTSiPR01837. MGTCSAPBPROT.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Requirement of MgtC for Brucella suis intramacrophage growth: a potential mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for adaptation to a low-Mg2+ environment."
    Lavigne J.-P., O'Callaghan D., Blanc-Potard A.-B.
    Infect. Immun. 73:3160-3163(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 1330.

Entry informationi

Entry nameiMGTC_BRUSU
AccessioniPrimary (citable) accession number: Q8FXM5
Secondary accession number(s): G0KEN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.