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Protein

Type IV secretion system protein VirB11

Gene

virB11

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The VirB system could be required for the establishment of the replication niche in the host.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi182 – 1898ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein VirB11
Gene namesi
Name:virB11
Ordered Locus Names:BRA0059, BS1330_II0059
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Type IV secretion system protein VirB11PRO_0000291439Add
BLAST

Expressioni

Inductioni

Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.

Structurei

Secondary structure

1
361
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 197Combined sources
Helixi21 – 255Combined sources
Helixi27 – 293Combined sources
Helixi30 – 334Combined sources
Beta strandi38 – 458Combined sources
Beta strandi48 – 536Combined sources
Beta strandi56 – 616Combined sources
Helixi67 – 8014Combined sources
Beta strandi86 – 894Combined sources
Beta strandi91 – 955Combined sources
Beta strandi101 – 1055Combined sources
Turni107 – 1093Combined sources
Beta strandi116 – 1205Combined sources
Helixi129 – 1346Combined sources
Turni135 – 1384Combined sources
Helixi150 – 16112Combined sources
Helixi164 – 17310Combined sources
Beta strandi178 – 1869Combined sources
Helixi188 – 1969Combined sources
Beta strandi205 – 2128Combined sources
Beta strandi220 – 2267Combined sources
Helixi241 – 2488Combined sources
Beta strandi254 – 2596Combined sources
Helixi265 – 27410Combined sources
Beta strandi281 – 2855Combined sources
Helixi289 – 30012Combined sources
Helixi306 – 3083Combined sources
Helixi311 – 32111Combined sources
Beta strandi324 – 3296Combined sources
Beta strandi333 – 3353Combined sources
Beta strandi338 – 3458Combined sources
Helixi347 – 3526Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GZAX-ray2.60A/B/C1-361[»]
ProteinModelPortaliQ8FXK7.
SMRiQ8FXK7. Positions 12-356.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8FXK7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP E family.Curated

Phylogenomic databases

HOGENOMiHOG000119934.
KOiK03196.
OMAiHANDTRD.
OrthoDBiEOG6X3W2S.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FXK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF
60 70 80 90 100
CERASAWEYY AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE
110 120 130 140 150
RIQIVRPPAC EHGTISVTIR KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP
160 170 180 190 200
FEQELLALKE AGDYMSFLRR AVQLERVIVV AGETGSGKTT LMKALMQEIP
210 220 230 240 250
FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT AATLLRSCLR
260 270 280 290 300
MKPTRILLAE LRGGEAYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV
310 320 330 340 350
LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK
360
RALSLQHSEK T
Length:361
Mass (Da):40,727
Last modified:March 1, 2003 - v1
Checksum:iD9DDD62F91D2CD3D
GO

Sequence cautioni

The sequence AAD56621.1 differs from that shown. Reason: Frameshift at position 309. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti125 – 1251T → P in AAD56621 (PubMed:10510235).Curated
Sequence conflicti207 – 2071T → A in AAD56621 (PubMed:10510235).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141604 Genomic DNA. Translation: AAD56621.1. Frameshift.
AE014292 Genomic DNA. Translation: AAN33271.1.
CP002998 Genomic DNA. Translation: AEM19551.1.

Genome annotation databases

EnsemblBacteriaiAAN33271; AAN33271; BRA0059.
AEM19551; AEM19551; BS1330_II0059.
KEGGibms:BRA0059.
bsi:BS1330_II0059.
PATRICi17792921. VBIBruSui107850_2279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141604 Genomic DNA. Translation: AAD56621.1. Frameshift.
AE014292 Genomic DNA. Translation: AAN33271.1.
CP002998 Genomic DNA. Translation: AEM19551.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2GZAX-ray2.60A/B/C1-361[»]
ProteinModelPortaliQ8FXK7.
SMRiQ8FXK7. Positions 12-356.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33271; AAN33271; BRA0059.
AEM19551; AEM19551; BS1330_II0059.
KEGGibms:BRA0059.
bsi:BS1330_II0059.
PATRICi17792921. VBIBruSui107850_2279.

Phylogenomic databases

HOGENOMiHOG000119934.
KOiK03196.
OMAiHANDTRD.
OrthoDBiEOG6X3W2S.

Miscellaneous databases

EvolutionaryTraceiQ8FXK7.
PROiQ8FXK7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis."
    O'Callaghan D., Cazevieille C., Allardet-Servent A., Boschiroli M.L., Bourg G., Foulongne V., Frutos P., Kulakov Y., Ramuz M.
    Mol. Microbiol. 33:1210-1220(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], EXPRESSION CONDITIONS.
    Strain: 1330.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiVIRBB_BRUSU
AccessioniPrimary (citable) accession number: Q8FXK7
Secondary accession number(s): G0KEQ7, Q9RPX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription of the operon is maximal in early exponential phase.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.