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Protein

Type IV secretion system protein VirB11

Gene

virB11

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The VirB system could be required for the establishment of the replication niche in the host.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi182 – 189ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV secretion system protein VirB11
Gene namesi
Name:virB11
Ordered Locus Names:BRA0059, BS1330_II0059
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914391 – 361Type IV secretion system protein VirB11Add BLAST361

Expressioni

Inductioni

Specifically induced within macrophages by phagosome acidification. Induced at 37 degrees Celsius in minimal medium, suggesting that nutritional stress is a regulating signal.

Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 19Combined sources7
Helixi21 – 25Combined sources5
Helixi27 – 29Combined sources3
Helixi30 – 33Combined sources4
Beta strandi38 – 45Combined sources8
Beta strandi48 – 53Combined sources6
Beta strandi56 – 61Combined sources6
Helixi67 – 80Combined sources14
Beta strandi86 – 89Combined sources4
Beta strandi91 – 95Combined sources5
Beta strandi101 – 105Combined sources5
Turni107 – 109Combined sources3
Beta strandi116 – 120Combined sources5
Helixi129 – 134Combined sources6
Turni135 – 138Combined sources4
Helixi150 – 161Combined sources12
Helixi164 – 173Combined sources10
Beta strandi178 – 186Combined sources9
Helixi188 – 196Combined sources9
Beta strandi205 – 212Combined sources8
Beta strandi220 – 226Combined sources7
Helixi241 – 248Combined sources8
Beta strandi254 – 259Combined sources6
Helixi265 – 274Combined sources10
Beta strandi281 – 285Combined sources5
Helixi289 – 300Combined sources12
Helixi306 – 308Combined sources3
Helixi311 – 321Combined sources11
Beta strandi324 – 329Combined sources6
Beta strandi333 – 335Combined sources3
Beta strandi338 – 345Combined sources8
Helixi347 – 352Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GZAX-ray2.60A/B/C1-361[»]
ProteinModelPortaliQ8FXK7.
SMRiQ8FXK7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8FXK7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GSP E family.Curated

Phylogenomic databases

HOGENOMiHOG000119934.
KOiK03196.
OMAiRPILSCI.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FXK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSNRSDFIV PDEAAVKRAA SVNFHLEPLR PWLDDPQITE VCVNRPGEVF
60 70 80 90 100
CERASAWEYY AVPNLDYEHL ISLGTATARF VDQDISDSRP VLSAILPMGE
110 120 130 140 150
RIQIVRPPAC EHGTISVTIR KPSFTRRTLE DYAQQGFFKH VRPMSKSLTP
160 170 180 190 200
FEQELLALKE AGDYMSFLRR AVQLERVIVV AGETGSGKTT LMKALMQEIP
210 220 230 240 250
FDQRLITIED VPELFLPDHP NHVHLFYPSE AKEEENAPVT AATLLRSCLR
260 270 280 290 300
MKPTRILLAE LRGGEAYDFI NVAASGHGGS ITSCHAGSCE LTFERLALMV
310 320 330 340 350
LQNRQGRQLP YEIIRRLLYL VVDVVVHVHN GVHDGTGRHI SEVWYDPNTK
360
RALSLQHSEK T
Length:361
Mass (Da):40,727
Last modified:March 1, 2003 - v1
Checksum:iD9DDD62F91D2CD3D
GO

Sequence cautioni

The sequence AAD56621 differs from that shown. Reason: Frameshift at position 309.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125T → P in AAD56621 (PubMed:10510235).Curated1
Sequence conflicti207T → A in AAD56621 (PubMed:10510235).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141604 Genomic DNA. Translation: AAD56621.1. Frameshift.
AE014292 Genomic DNA. Translation: AAN33271.1.
CP002998 Genomic DNA. Translation: AEM19551.1.

Genome annotation databases

EnsemblBacteriaiAAN33271; AAN33271; BRA0059.
AEM19551; AEM19551; BS1330_II0059.
KEGGibms:BRA0059.
bsi:BS1330_II0059.
PATRICi17792921. VBIBruSui107850_2279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF141604 Genomic DNA. Translation: AAD56621.1. Frameshift.
AE014292 Genomic DNA. Translation: AAN33271.1.
CP002998 Genomic DNA. Translation: AEM19551.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GZAX-ray2.60A/B/C1-361[»]
ProteinModelPortaliQ8FXK7.
SMRiQ8FXK7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33271; AAN33271; BRA0059.
AEM19551; AEM19551; BS1330_II0059.
KEGGibms:BRA0059.
bsi:BS1330_II0059.
PATRICi17792921. VBIBruSui107850_2279.

Phylogenomic databases

HOGENOMiHOG000119934.
KOiK03196.
OMAiRPILSCI.

Miscellaneous databases

EvolutionaryTraceiQ8FXK7.
PROiQ8FXK7.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001482. T2SS_protein-E.
IPR014155. VirB11.
[Graphical view]
PfamiPF00437. T2SSE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02788. VirB11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVIRBB_BRUSU
AccessioniPrimary (citable) accession number: Q8FXK7
Secondary accession number(s): G0KEQ7, Q9RPX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Transcription of the operon is maximal in early exponential phase.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.