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Q8FX87

- CH60_BRUSU

UniProt

Q8FX87 - CH60_BRUSU

Protein

60 kDa chaperonin

Gene

groL

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein refolding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60 kDa chaperoninUniRule annotation
    Alternative name(s):
    GroEL proteinUniRule annotation
    Protein Cpn60UniRule annotation
    Gene namesi
    Name:groLUniRule annotation
    Synonyms:groELUniRule annotation
    Ordered Locus Names:BRA0195, BS1330_II0192
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 54654660 kDa chaperoninPRO_0000063304Add
    BLAST

    Proteomic databases

    PRIDEiQ8FX87.

    Interactioni

    Subunit structurei

    Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BRA0195.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FX87.
    SMRiQ8FX87. Positions 2-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the chaperonin (HSP60) family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000076290.
    KOiK04077.
    OMAiVLFGNDA.
    OrthoDBiEOG6JDWBZ.

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.50.7.10. 1 hit.
    HAMAPiMF_00600. CH60.
    InterProiIPR018370. Chaperonin_Cpn60_CS.
    IPR001844. Chaprnin_Cpn60.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00298. CHAPERONIN60.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02348. GroEL. 1 hit.
    PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FX87-1 [UniParc]FASTAAdd to Basket

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    MAAKDVKFGR TAREKMLRGV DILADAVKVT LGPKGRNVVI DKSFGAPRIT    50
    KDGVSVAKEV ELEDKFENMG AQMLREVASK TNDTAGDGTT TATVLGQAIV 100
    QEGAKAVAAG MNPMDLKRGI DLAVNEVVAE LLKKAKKINT SEEVAQVGTI 150
    SANGEAEIGK MIAEAMQKVG NEGVITVEEA KTAETELEVV EGMQFDRGYL 200
    SPYFVTNPEK MVADLEDAYI LLHEKKLSNL QALLPVLEAV VQTSKPLLII 250
    AEDVEGEALA TLVVNKLRGG LKIAAVKAPG FGDRRKAMLE DIAILTGGQV 300
    ISEDLGIKLE SVTLDMLGRA KKVSISKENT TIVDGAGQKA EIDARVGQIK 350
    QQIEETTSDY DREKLQERLA KLAGGVAVIR VGGATEVEVK EKKDRVDDAL 400
    NATRAAVEEG IVAGGGTALL RASTKITAKG VNADQEAGIN IVRRAIQAPA 450
    RQITTNAGEE ASVIVGKILE NTSETFGYNT ANGEYGDLIS LGIVDPVKVV 500
    RTALQNAASV AGLLITTEAM IAELPKKDAA PAGMPGGMGG MGGMDF 546
    Length:546
    Mass (Da):57,501
    Last modified:March 1, 2003 - v1
    Checksum:i2E4046EDC121A30A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33401.1.
    CP002998 Genomic DNA. Translation: AEM19678.1.
    RefSeqiNP_699396.1. NC_004311.2.
    YP_005613904.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN33401; AAN33401; BRA0195.
    AEM19678; AEM19678; BS1330_II0192.
    GeneIDi1164632.
    12139626.
    KEGGibms:BRA0195.
    bsi:BS1330_II0192.
    PATRICi17793187. VBIBruSui107850_2412.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33401.1 .
    CP002998 Genomic DNA. Translation: AEM19678.1 .
    RefSeqi NP_699396.1. NC_004311.2.
    YP_005613904.1. NC_017250.1.

    3D structure databases

    ProteinModelPortali Q8FX87.
    SMRi Q8FX87. Positions 2-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA0195.

    Proteomic databases

    PRIDEi Q8FX87.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN33401 ; AAN33401 ; BRA0195 .
    AEM19678 ; AEM19678 ; BS1330_II0192 .
    GeneIDi 1164632.
    12139626.
    KEGGi bms:BRA0195.
    bsi:BS1330_II0192.
    PATRICi 17793187. VBIBruSui107850_2412.

    Phylogenomic databases

    HOGENOMi HOG000076290.
    KOi K04077.
    OMAi VLFGNDA.
    OrthoDBi EOG6JDWBZ.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.50.7.10. 1 hit.
    HAMAPi MF_00600. CH60.
    InterProi IPR018370. Chaperonin_Cpn60_CS.
    IPR001844. Chaprnin_Cpn60.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00298. CHAPERONIN60.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02348. GroEL. 1 hit.
    PROSITEi PS00296. CHAPERONINS_CPN60. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiCH60_BRUSU
    AccessioniPrimary (citable) accession number: Q8FX87
    Secondary accession number(s): G0KF34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3