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Q8FWV9

- BEPG_BRUSU

UniProt

Q8FWV9 - BEPG_BRUSU

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Protein

Efflux pump membrane transporter BepG

Gene
bepG, BRA0334, BS1330_II0331
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.1 Publication

GO - Molecular functioni

  1. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3405-MONOMER.
RETL1328306-WGS:GSTH-3418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Efflux pump membrane transporter BepG
Gene namesi
Name:bepG
Ordered Locus Names:BRA0334, BS1330_II0331
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321Helical; Reviewed predictionAdd
BLAST
Transmembranei342 – 36221Helical; Reviewed predictionAdd
BLAST
Transmembranei368 – 38821Helical; Reviewed predictionAdd
BLAST
Transmembranei395 – 41521Helical; Reviewed predictionAdd
BLAST
Transmembranei444 – 46421Helical; Reviewed predictionAdd
BLAST
Transmembranei478 – 49821Helical; Reviewed predictionAdd
BLAST
Transmembranei540 – 56021Helical; Reviewed predictionAdd
BLAST
Transmembranei876 – 89621Helical; Reviewed predictionAdd
BLAST
Transmembranei898 – 91821Helical; Reviewed predictionAdd
BLAST
Transmembranei930 – 95021Helical; Reviewed predictionAdd
BLAST
Transmembranei975 – 99521Helical; Reviewed predictionAdd
BLAST
Transmembranei1007 – 102721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Shows no differences in the resistance profile to different dyes, detergents and antimicrobials.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10741074Efflux pump membrane transporter BepGPRO_0000390651Add
BLAST

Expressioni

Inductioni

Induced in the absence of BepDE.1 Publication

Interactioni

Subunit structurei

Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepF.1 Publication

Protein-protein interaction databases

STRINGi204722.BRA0334.

Structurei

3D structure databases

ProteinModelPortaliQ8FWV9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0841.
HOGENOMiHOG000158129.
OMAiSIYTQIG.
OrthoDBiEOG683S5M.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004764. HAE1.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00915. 2A0602. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FWV9-1 [UniParc]FASTAAdd to Basket

« Hide

MLSSVFINRP RLAIVIAIVI TLAGLIAVTR IPVAQFPDIV PPQVSVTATY     50
PGASAETVEA AIAQPIEAQV NGVDDMIYMS STSGNNGTYT LTVTFKVGSD 100
PNLNTVNVQN RVRLAEANLP QEVTRLGVTV KKQSSSFLQI ITLLSPDSRY 150
DELFLNNYGV INVVDRLARV PGVGQAQSFG TFNYSMRIWF NTDALTSLNL 200
TPNDIVNAIS SQNVQAAVGR LGAPPMTDQQ QIQLTLTTQG RLTDAKQFEN 250
IIIRANPDGS SVRLKDVARV ELAAQSYDTI GRLNGKPASV IAVYQAPGSN 300
AVAAAEGVRN VMEQLKQSFP AGLDYKITYD TTVFVSSTIH EVIKTLLEAF 350
VLVVVVVFIF LGNFRATLIP TLAVPVSLIG TFAVLLVLGF SANTISLFAM 400
ILAIGIVVDD AIVVVENVER VMAETGLPPK EAAKQAMQEI TAPIIAITLV 450
LLSVFVPVAF IPGITGALYA QFALTVSVAM LISAINALTL SPALCGVFLK 500
PHQGRKKSLY GRTMDKLSSG IEKISDGYAH IVRRLVRMAF LSIVLVAGLG 550
AGAYFLNTIV PTGFLPEEDQ GLFFVQVNLP PAASQSRTAA VVSEIEADIT 600
KMAGVADVTS VTGFSFIDGL AVSNAGLMIV TLKPLEERLK DNITVFDVIA 650
EVNRRTAAIP SAVAITMNLP PILGLGSSGG FQYQLEDQEG QSPQQLASVA 700
QGLVMAANQN PKLSRVFTTF ATDTPQLNLN IDRQKALSLG VSPNNIIQAL 750
QSTLGGYFVN NFNTLGRTWQ VIIQGEQQDR KTVEDIYRIN VRSSHGDMVP 800
LRSLVSVEER LGPLYITRYN NYRSASIQGN AAPGVSSGEA LAAMAQVSKT 850
TLPSGYGYEW TGTALQELQA AGQTSMILAL AVLFAYLFLV ALYESWTIPV 900
GVLLSVTAGL AGAMLALWIT GLSNDIYAQI GIVVLIALAS KNGILIVEFA 950
KERREEGVPL EQAAIIGARQ RFRPVMMTSF AFILGLVPLV IAVGAAAASR 1000
RAVGTSVFGG MIAASAVGIF LIPMLYVVLE RVREWGHARI LRKPLYEEEK 1050
QEKADGDASG PTVPPTQPED RGLS 1074
Length:1,074
Mass (Da):114,902
Last modified:March 1, 2003 - v1
Checksum:i79F0B440F8A96438
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN33534.1.
CP002998 Genomic DNA. Translation: AEM19813.1.
RefSeqiNP_699529.1. NC_004311.2.
YP_005614039.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33534; AAN33534; BRA0334.
AEM19813; AEM19813; BS1330_II0331.
GeneIDi1164772.
12139766.
KEGGibms:BRA0334.
bsi:BS1330_II0331.
PATRICi17793463. VBIBruSui107850_2549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN33534.1 .
CP002998 Genomic DNA. Translation: AEM19813.1 .
RefSeqi NP_699529.1. NC_004311.2.
YP_005614039.1. NC_017250.1.

3D structure databases

ProteinModelPortali Q8FWV9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BRA0334.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN33534 ; AAN33534 ; BRA0334 .
AEM19813 ; AEM19813 ; BS1330_II0331 .
GeneIDi 1164772.
12139766.
KEGGi bms:BRA0334.
bsi:BS1330_II0331.
PATRICi 17793463. VBIBruSui107850_2549.

Phylogenomic databases

eggNOGi COG0841.
HOGENOMi HOG000158129.
OMAi SIYTQIG.
OrthoDBi EOG683S5M.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-3405-MONOMER.
RETL1328306-WGS:GSTH-3418-MONOMER.

Family and domain databases

Gene3Di 3.30.2090.10. 2 hits.
InterProi IPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004764. HAE1.
[Graphical view ]
Pfami PF00873. ACR_tran. 1 hit.
[Graphical view ]
PRINTSi PR00702. ACRIFLAVINRP.
SUPFAMi SSF82714. SSF82714. 2 hits.
TIGRFAMsi TIGR00915. 2A0602. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Interplay between two RND systems mediating antimicrobial resistance in Brucella suis."
    Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D., Zorreguieta A.
    J. Bacteriol. 191:2530-2540(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RESISTANCE, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: 1330.

Entry informationi

Entry nameiBEPG_BRUSU
AccessioniPrimary (citable) accession number: Q8FWV9
Secondary accession number(s): G0KC75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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