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Q8FWV9

- BEPG_BRUSU

UniProt

Q8FWV9 - BEPG_BRUSU

Protein

Efflux pump membrane transporter BepG

Gene

bepG

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.1 Publication

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3405-MONOMER.
    RETL1328306-WGS:GSTH-3418-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Efflux pump membrane transporter BepG
    Gene namesi
    Name:bepG
    Ordered Locus Names:BRA0334, BS1330_II0331
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Shows no differences in the resistance profile to different dyes, detergents and antimicrobials.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10741074Efflux pump membrane transporter BepGPRO_0000390651Add
    BLAST

    Expressioni

    Inductioni

    Induced in the absence of BepDE.1 Publication

    Interactioni

    Subunit structurei

    Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepF.1 Publication

    Protein-protein interaction databases

    STRINGi204722.BRA0334.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FWV9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei540 – 56021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei876 – 89621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei898 – 91821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei930 – 95021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei975 – 99521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1007 – 102721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0841.
    HOGENOMiHOG000158129.
    OMAiSIYTQIG.
    OrthoDBiEOG683S5M.

    Family and domain databases

    Gene3Di3.30.2090.10. 2 hits.
    InterProiIPR027463. AcrB_DN_DC_subdom.
    IPR001036. Acrflvin-R.
    IPR004764. HAE1.
    [Graphical view]
    PfamiPF00873. ACR_tran. 1 hit.
    [Graphical view]
    PRINTSiPR00702. ACRIFLAVINRP.
    SUPFAMiSSF82714. SSF82714. 2 hits.
    TIGRFAMsiTIGR00915. 2A0602. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FWV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSSVFINRP RLAIVIAIVI TLAGLIAVTR IPVAQFPDIV PPQVSVTATY     50
    PGASAETVEA AIAQPIEAQV NGVDDMIYMS STSGNNGTYT LTVTFKVGSD 100
    PNLNTVNVQN RVRLAEANLP QEVTRLGVTV KKQSSSFLQI ITLLSPDSRY 150
    DELFLNNYGV INVVDRLARV PGVGQAQSFG TFNYSMRIWF NTDALTSLNL 200
    TPNDIVNAIS SQNVQAAVGR LGAPPMTDQQ QIQLTLTTQG RLTDAKQFEN 250
    IIIRANPDGS SVRLKDVARV ELAAQSYDTI GRLNGKPASV IAVYQAPGSN 300
    AVAAAEGVRN VMEQLKQSFP AGLDYKITYD TTVFVSSTIH EVIKTLLEAF 350
    VLVVVVVFIF LGNFRATLIP TLAVPVSLIG TFAVLLVLGF SANTISLFAM 400
    ILAIGIVVDD AIVVVENVER VMAETGLPPK EAAKQAMQEI TAPIIAITLV 450
    LLSVFVPVAF IPGITGALYA QFALTVSVAM LISAINALTL SPALCGVFLK 500
    PHQGRKKSLY GRTMDKLSSG IEKISDGYAH IVRRLVRMAF LSIVLVAGLG 550
    AGAYFLNTIV PTGFLPEEDQ GLFFVQVNLP PAASQSRTAA VVSEIEADIT 600
    KMAGVADVTS VTGFSFIDGL AVSNAGLMIV TLKPLEERLK DNITVFDVIA 650
    EVNRRTAAIP SAVAITMNLP PILGLGSSGG FQYQLEDQEG QSPQQLASVA 700
    QGLVMAANQN PKLSRVFTTF ATDTPQLNLN IDRQKALSLG VSPNNIIQAL 750
    QSTLGGYFVN NFNTLGRTWQ VIIQGEQQDR KTVEDIYRIN VRSSHGDMVP 800
    LRSLVSVEER LGPLYITRYN NYRSASIQGN AAPGVSSGEA LAAMAQVSKT 850
    TLPSGYGYEW TGTALQELQA AGQTSMILAL AVLFAYLFLV ALYESWTIPV 900
    GVLLSVTAGL AGAMLALWIT GLSNDIYAQI GIVVLIALAS KNGILIVEFA 950
    KERREEGVPL EQAAIIGARQ RFRPVMMTSF AFILGLVPLV IAVGAAAASR 1000
    RAVGTSVFGG MIAASAVGIF LIPMLYVVLE RVREWGHARI LRKPLYEEEK 1050
    QEKADGDASG PTVPPTQPED RGLS 1074
    Length:1,074
    Mass (Da):114,902
    Last modified:March 1, 2003 - v1
    Checksum:i79F0B440F8A96438
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33534.1.
    CP002998 Genomic DNA. Translation: AEM19813.1.
    RefSeqiNP_699529.1. NC_004311.2.
    YP_005614039.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN33534; AAN33534; BRA0334.
    AEM19813; AEM19813; BS1330_II0331.
    GeneIDi1164772.
    12139766.
    KEGGibms:BRA0334.
    bsi:BS1330_II0331.
    PATRICi17793463. VBIBruSui107850_2549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33534.1 .
    CP002998 Genomic DNA. Translation: AEM19813.1 .
    RefSeqi NP_699529.1. NC_004311.2.
    YP_005614039.1. NC_017250.1.

    3D structure databases

    ProteinModelPortali Q8FWV9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA0334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN33534 ; AAN33534 ; BRA0334 .
    AEM19813 ; AEM19813 ; BS1330_II0331 .
    GeneIDi 1164772.
    12139766.
    KEGGi bms:BRA0334.
    bsi:BS1330_II0331.
    PATRICi 17793463. VBIBruSui107850_2549.

    Phylogenomic databases

    eggNOGi COG0841.
    HOGENOMi HOG000158129.
    OMAi SIYTQIG.
    OrthoDBi EOG683S5M.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-3405-MONOMER.
    RETL1328306-WGS:GSTH-3418-MONOMER.

    Family and domain databases

    Gene3Di 3.30.2090.10. 2 hits.
    InterProi IPR027463. AcrB_DN_DC_subdom.
    IPR001036. Acrflvin-R.
    IPR004764. HAE1.
    [Graphical view ]
    Pfami PF00873. ACR_tran. 1 hit.
    [Graphical view ]
    PRINTSi PR00702. ACRIFLAVINRP.
    SUPFAMi SSF82714. SSF82714. 2 hits.
    TIGRFAMsi TIGR00915. 2A0602. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    3. "Interplay between two RND systems mediating antimicrobial resistance in Brucella suis."
      Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D., Zorreguieta A.
      J. Bacteriol. 191:2530-2540(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN RESISTANCE, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE.
      Strain: 1330.

    Entry informationi

    Entry nameiBEPG_BRUSU
    AccessioniPrimary (citable) accession number: Q8FWV9
    Secondary accession number(s): G0KC75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3