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Protein

Efflux pump membrane transporter BepG

Gene

bepG

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Efflux pump membrane transporter BepG
Gene namesi
Name:bepG
Ordered Locus Names:BRA0334, BS1330_II0331
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21
Transmembranei876 – 896HelicalSequence analysisAdd BLAST21
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Transmembranei930 – 950HelicalSequence analysisAdd BLAST21
Transmembranei975 – 995HelicalSequence analysisAdd BLAST21
Transmembranei1007 – 1027HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Shows no differences in the resistance profile to different dyes, detergents and antimicrobials.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003906511 – 1074Efflux pump membrane transporter BepGAdd BLAST1074

Proteomic databases

PRIDEiQ8FWV9

Expressioni

Inductioni

Induced in the absence of BepDE.1 Publication

Interactioni

Subunit structurei

Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepF.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8FWV9
SMRiQ8FWV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000158129
OMAiLAGYEIM

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463 AcrB_DN_DC_subdom
IPR001036 Acrflvin-R
IPR004764 HAE1
PANTHERiPTHR32063 PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873 ACR_tran, 1 hit
PRINTSiPR00702 ACRIFLAVINRP
SUPFAMiSSF82714 SSF82714, 2 hits
TIGRFAMsiTIGR00915 2A0602, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FWV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSVFINRP RLAIVIAIVI TLAGLIAVTR IPVAQFPDIV PPQVSVTATY
60 70 80 90 100
PGASAETVEA AIAQPIEAQV NGVDDMIYMS STSGNNGTYT LTVTFKVGSD
110 120 130 140 150
PNLNTVNVQN RVRLAEANLP QEVTRLGVTV KKQSSSFLQI ITLLSPDSRY
160 170 180 190 200
DELFLNNYGV INVVDRLARV PGVGQAQSFG TFNYSMRIWF NTDALTSLNL
210 220 230 240 250
TPNDIVNAIS SQNVQAAVGR LGAPPMTDQQ QIQLTLTTQG RLTDAKQFEN
260 270 280 290 300
IIIRANPDGS SVRLKDVARV ELAAQSYDTI GRLNGKPASV IAVYQAPGSN
310 320 330 340 350
AVAAAEGVRN VMEQLKQSFP AGLDYKITYD TTVFVSSTIH EVIKTLLEAF
360 370 380 390 400
VLVVVVVFIF LGNFRATLIP TLAVPVSLIG TFAVLLVLGF SANTISLFAM
410 420 430 440 450
ILAIGIVVDD AIVVVENVER VMAETGLPPK EAAKQAMQEI TAPIIAITLV
460 470 480 490 500
LLSVFVPVAF IPGITGALYA QFALTVSVAM LISAINALTL SPALCGVFLK
510 520 530 540 550
PHQGRKKSLY GRTMDKLSSG IEKISDGYAH IVRRLVRMAF LSIVLVAGLG
560 570 580 590 600
AGAYFLNTIV PTGFLPEEDQ GLFFVQVNLP PAASQSRTAA VVSEIEADIT
610 620 630 640 650
KMAGVADVTS VTGFSFIDGL AVSNAGLMIV TLKPLEERLK DNITVFDVIA
660 670 680 690 700
EVNRRTAAIP SAVAITMNLP PILGLGSSGG FQYQLEDQEG QSPQQLASVA
710 720 730 740 750
QGLVMAANQN PKLSRVFTTF ATDTPQLNLN IDRQKALSLG VSPNNIIQAL
760 770 780 790 800
QSTLGGYFVN NFNTLGRTWQ VIIQGEQQDR KTVEDIYRIN VRSSHGDMVP
810 820 830 840 850
LRSLVSVEER LGPLYITRYN NYRSASIQGN AAPGVSSGEA LAAMAQVSKT
860 870 880 890 900
TLPSGYGYEW TGTALQELQA AGQTSMILAL AVLFAYLFLV ALYESWTIPV
910 920 930 940 950
GVLLSVTAGL AGAMLALWIT GLSNDIYAQI GIVVLIALAS KNGILIVEFA
960 970 980 990 1000
KERREEGVPL EQAAIIGARQ RFRPVMMTSF AFILGLVPLV IAVGAAAASR
1010 1020 1030 1040 1050
RAVGTSVFGG MIAASAVGIF LIPMLYVVLE RVREWGHARI LRKPLYEEEK
1060 1070
QEKADGDASG PTVPPTQPED RGLS
Length:1,074
Mass (Da):114,902
Last modified:March 1, 2003 - v1
Checksum:i79F0B440F8A96438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA Translation: AAN33534.1
CP002998 Genomic DNA Translation: AEM19813.1
RefSeqiWP_006191785.1, NZ_KN046805.1

Genome annotation databases

EnsemblBacteriaiAAN33534; AAN33534; BRA0334
AEM19813; AEM19813; BS1330_II0331
KEGGibms:BRA0334
bsi:BS1330_II0331
PATRICifig|204722.22.peg.3114

Similar proteinsi

Entry informationi

Entry nameiBEPG_BRUSU
AccessioniPrimary (citable) accession number: Q8FWV9
Secondary accession number(s): G0KC75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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