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Q8FWV9 (BEPG_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Efflux pump membrane transporter BepG
Gene names
Name:bepG
Ordered Locus Names:BRA0334, BS1330_II0331
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length1074 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE. Ref.3

Subunit structure

Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepF. Ref.3

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential.

Induction

Induced in the absence of BepDE. Ref.3

Disruption phenotype

Shows no differences in the resistance profile to different dyes, detergents and antimicrobials. Ref.3

Sequence similarities

Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10741074Efflux pump membrane transporter BepG
PRO_0000390651

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane342 – 36221Helical; Potential
Transmembrane368 – 38821Helical; Potential
Transmembrane395 – 41521Helical; Potential
Transmembrane444 – 46421Helical; Potential
Transmembrane478 – 49821Helical; Potential
Transmembrane540 – 56021Helical; Potential
Transmembrane876 – 89621Helical; Potential
Transmembrane898 – 91821Helical; Potential
Transmembrane930 – 95021Helical; Potential
Transmembrane975 – 99521Helical; Potential
Transmembrane1007 – 102721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8FWV9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 79F0B440F8A96438

FASTA1,074114,902
        10         20         30         40         50         60 
MLSSVFINRP RLAIVIAIVI TLAGLIAVTR IPVAQFPDIV PPQVSVTATY PGASAETVEA 

        70         80         90        100        110        120 
AIAQPIEAQV NGVDDMIYMS STSGNNGTYT LTVTFKVGSD PNLNTVNVQN RVRLAEANLP 

       130        140        150        160        170        180 
QEVTRLGVTV KKQSSSFLQI ITLLSPDSRY DELFLNNYGV INVVDRLARV PGVGQAQSFG 

       190        200        210        220        230        240 
TFNYSMRIWF NTDALTSLNL TPNDIVNAIS SQNVQAAVGR LGAPPMTDQQ QIQLTLTTQG 

       250        260        270        280        290        300 
RLTDAKQFEN IIIRANPDGS SVRLKDVARV ELAAQSYDTI GRLNGKPASV IAVYQAPGSN 

       310        320        330        340        350        360 
AVAAAEGVRN VMEQLKQSFP AGLDYKITYD TTVFVSSTIH EVIKTLLEAF VLVVVVVFIF 

       370        380        390        400        410        420 
LGNFRATLIP TLAVPVSLIG TFAVLLVLGF SANTISLFAM ILAIGIVVDD AIVVVENVER 

       430        440        450        460        470        480 
VMAETGLPPK EAAKQAMQEI TAPIIAITLV LLSVFVPVAF IPGITGALYA QFALTVSVAM 

       490        500        510        520        530        540 
LISAINALTL SPALCGVFLK PHQGRKKSLY GRTMDKLSSG IEKISDGYAH IVRRLVRMAF 

       550        560        570        580        590        600 
LSIVLVAGLG AGAYFLNTIV PTGFLPEEDQ GLFFVQVNLP PAASQSRTAA VVSEIEADIT 

       610        620        630        640        650        660 
KMAGVADVTS VTGFSFIDGL AVSNAGLMIV TLKPLEERLK DNITVFDVIA EVNRRTAAIP 

       670        680        690        700        710        720 
SAVAITMNLP PILGLGSSGG FQYQLEDQEG QSPQQLASVA QGLVMAANQN PKLSRVFTTF 

       730        740        750        760        770        780 
ATDTPQLNLN IDRQKALSLG VSPNNIIQAL QSTLGGYFVN NFNTLGRTWQ VIIQGEQQDR 

       790        800        810        820        830        840 
KTVEDIYRIN VRSSHGDMVP LRSLVSVEER LGPLYITRYN NYRSASIQGN AAPGVSSGEA 

       850        860        870        880        890        900 
LAAMAQVSKT TLPSGYGYEW TGTALQELQA AGQTSMILAL AVLFAYLFLV ALYESWTIPV 

       910        920        930        940        950        960 
GVLLSVTAGL AGAMLALWIT GLSNDIYAQI GIVVLIALAS KNGILIVEFA KERREEGVPL 

       970        980        990       1000       1010       1020 
EQAAIIGARQ RFRPVMMTSF AFILGLVPLV IAVGAAAASR RAVGTSVFGG MIAASAVGIF 

      1030       1040       1050       1060       1070 
LIPMLYVVLE RVREWGHARI LRKPLYEEEK QEKADGDASG PTVPPTQPED RGLS 

« Hide

References

« Hide 'large scale' references
[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"Interplay between two RND systems mediating antimicrobial resistance in Brucella suis."
Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D., Zorreguieta A.
J. Bacteriol. 191:2530-2540(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN RESISTANCE, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE.
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014292 Genomic DNA. Translation: AAN33534.1.
CP002998 Genomic DNA. Translation: AEM19813.1.
RefSeqNP_699529.1. NC_004311.2.
YP_005614039.1. NC_017250.1.

3D structure databases

ProteinModelPortalQ8FWV9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BRA0334.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN33534; AAN33534; BRA0334.
AEM19813; AEM19813; BS1330_II0331.
GeneID1164772.
12139766.
KEGGbms:BRA0334.
bsi:BS1330_II0331.
PATRIC17793463. VBIBruSui107850_2549.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0841.
HOGENOMHOG000158129.
OMADYKITYD.
OrthoDBEOG683S5M.
ProtClustDBCLSK2304408.

Family and domain databases

Gene3D3.30.2090.10. 2 hits.
InterProIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004764. HAE1.
[Graphical view]
PfamPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSPR00702. ACRIFLAVINRP.
SUPFAMSSF82714. SSF82714. 2 hits.
TIGRFAMsTIGR00915. 2A0602. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBEPG_BRUSU
AccessionPrimary (citable) accession number: Q8FWV9
Secondary accession number(s): G0KC75
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names