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Protein

Efflux pump membrane transporter BepG

Gene

bepG

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to resistance to some drugs, such as deoxycholate, sodium dodecyl sulfate and nalidixic acid, in the absence of BepD and BepE.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3405-MONOMER.
RETL1328306-WGS:GSTH-3418-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Efflux pump membrane transporter BepG
Gene namesi
Name:bepG
Ordered Locus Names:BRA0334, BS1330_II0331
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome II

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Transmembranei444 – 46421HelicalSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Transmembranei540 – 56021HelicalSequence AnalysisAdd
BLAST
Transmembranei876 – 89621HelicalSequence AnalysisAdd
BLAST
Transmembranei898 – 91821HelicalSequence AnalysisAdd
BLAST
Transmembranei930 – 95021HelicalSequence AnalysisAdd
BLAST
Transmembranei975 – 99521HelicalSequence AnalysisAdd
BLAST
Transmembranei1007 – 102721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Shows no differences in the resistance profile to different dyes, detergents and antimicrobials.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10741074Efflux pump membrane transporter BepGPRO_0000390651Add
BLAST

Expressioni

Inductioni

Induced in the absence of BepDE.1 Publication

Interactioni

Subunit structurei

Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepC and BepF.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8FWV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0841.
HOGENOMiHOG000158129.
OMAiKNASGEM.
OrthoDBiEOG683S5M.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004764. HAE1.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00915. 2A0602. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FWV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSVFINRP RLAIVIAIVI TLAGLIAVTR IPVAQFPDIV PPQVSVTATY
60 70 80 90 100
PGASAETVEA AIAQPIEAQV NGVDDMIYMS STSGNNGTYT LTVTFKVGSD
110 120 130 140 150
PNLNTVNVQN RVRLAEANLP QEVTRLGVTV KKQSSSFLQI ITLLSPDSRY
160 170 180 190 200
DELFLNNYGV INVVDRLARV PGVGQAQSFG TFNYSMRIWF NTDALTSLNL
210 220 230 240 250
TPNDIVNAIS SQNVQAAVGR LGAPPMTDQQ QIQLTLTTQG RLTDAKQFEN
260 270 280 290 300
IIIRANPDGS SVRLKDVARV ELAAQSYDTI GRLNGKPASV IAVYQAPGSN
310 320 330 340 350
AVAAAEGVRN VMEQLKQSFP AGLDYKITYD TTVFVSSTIH EVIKTLLEAF
360 370 380 390 400
VLVVVVVFIF LGNFRATLIP TLAVPVSLIG TFAVLLVLGF SANTISLFAM
410 420 430 440 450
ILAIGIVVDD AIVVVENVER VMAETGLPPK EAAKQAMQEI TAPIIAITLV
460 470 480 490 500
LLSVFVPVAF IPGITGALYA QFALTVSVAM LISAINALTL SPALCGVFLK
510 520 530 540 550
PHQGRKKSLY GRTMDKLSSG IEKISDGYAH IVRRLVRMAF LSIVLVAGLG
560 570 580 590 600
AGAYFLNTIV PTGFLPEEDQ GLFFVQVNLP PAASQSRTAA VVSEIEADIT
610 620 630 640 650
KMAGVADVTS VTGFSFIDGL AVSNAGLMIV TLKPLEERLK DNITVFDVIA
660 670 680 690 700
EVNRRTAAIP SAVAITMNLP PILGLGSSGG FQYQLEDQEG QSPQQLASVA
710 720 730 740 750
QGLVMAANQN PKLSRVFTTF ATDTPQLNLN IDRQKALSLG VSPNNIIQAL
760 770 780 790 800
QSTLGGYFVN NFNTLGRTWQ VIIQGEQQDR KTVEDIYRIN VRSSHGDMVP
810 820 830 840 850
LRSLVSVEER LGPLYITRYN NYRSASIQGN AAPGVSSGEA LAAMAQVSKT
860 870 880 890 900
TLPSGYGYEW TGTALQELQA AGQTSMILAL AVLFAYLFLV ALYESWTIPV
910 920 930 940 950
GVLLSVTAGL AGAMLALWIT GLSNDIYAQI GIVVLIALAS KNGILIVEFA
960 970 980 990 1000
KERREEGVPL EQAAIIGARQ RFRPVMMTSF AFILGLVPLV IAVGAAAASR
1010 1020 1030 1040 1050
RAVGTSVFGG MIAASAVGIF LIPMLYVVLE RVREWGHARI LRKPLYEEEK
1060 1070
QEKADGDASG PTVPPTQPED RGLS
Length:1,074
Mass (Da):114,902
Last modified:March 1, 2003 - v1
Checksum:i79F0B440F8A96438
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33534.1.
CP002998 Genomic DNA. Translation: AEM19813.1.
RefSeqiWP_006191785.1. NZ_KN046805.1.

Genome annotation databases

EnsemblBacteriaiAAN33534; AAN33534; BRA0334.
AEM19813; AEM19813; BS1330_II0331.
KEGGibms:BRA0334.
bsi:BS1330_II0331.
PATRICi17793463. VBIBruSui107850_2549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33534.1.
CP002998 Genomic DNA. Translation: AEM19813.1.
RefSeqiWP_006191785.1. NZ_KN046805.1.

3D structure databases

ProteinModelPortaliQ8FWV9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33534; AAN33534; BRA0334.
AEM19813; AEM19813; BS1330_II0331.
KEGGibms:BRA0334.
bsi:BS1330_II0331.
PATRICi17793463. VBIBruSui107850_2549.

Phylogenomic databases

eggNOGiCOG0841.
HOGENOMiHOG000158129.
OMAiKNASGEM.
OrthoDBiEOG683S5M.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3405-MONOMER.
RETL1328306-WGS:GSTH-3418-MONOMER.

Family and domain databases

Gene3Di3.30.2090.10. 2 hits.
InterProiIPR027463. AcrB_DN_DC_subdom.
IPR001036. Acrflvin-R.
IPR004764. HAE1.
[Graphical view]
PfamiPF00873. ACR_tran. 1 hit.
[Graphical view]
PRINTSiPR00702. ACRIFLAVINRP.
SUPFAMiSSF82714. SSF82714. 2 hits.
TIGRFAMsiTIGR00915. 2A0602. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Interplay between two RND systems mediating antimicrobial resistance in Brucella suis."
    Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D., Zorreguieta A.
    J. Bacteriol. 191:2530-2540(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RESISTANCE, SUBUNIT, INDUCTION, DISRUPTION PHENOTYPE.
    Strain: 1330.

Entry informationi

Entry nameiBEPG_BRUSU
AccessioniPrimary (citable) accession number: Q8FWV9
Secondary accession number(s): G0KC75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.