Q8FWV4 (HDEA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable acid stress chaperone HdeA

Gene names

Name:	hdeA
Ordered Locus Names:	BRA0341, BS1330_II0338

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins By similarity. HAMAP-Rule MF_00946
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the HdeA family.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Chaperone
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	By similarity
	Chain	27 – 114	88	Probable acid stress chaperone HdeA HAMAP-Rule MF_00946		PRO_0000338637
Amino acid modifications
	Disulfide bond	46 ↔ 94		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FWV4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: EA4B34293EF0B73E	FASTA	114	12,362
	10 20 30 40 50 60 MIKALFNKNT ALAAVTILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN GLEESFKPTV 70 80 90 100 110 VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA SFWKKAEAEL KKVF

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014292 Genomic DNA. Translation: AAN33539.1. CP002998 Genomic DNA. Translation: AEM19818.1.
RefSeq	NP_699534.1. NC_004311.2. YP_005614044.1. NC_017250.1.
3D structure databases
ProteinModelPortal	Q8FWV4.
SMR	Q8FWV4. Positions 38-113.
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BRA0341.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN33539; AAN33539; BRA0341. AEM19818; AEM19818; BS1330_II0338.
GeneID	1164779. 12139773.
KEGG	bms:BRA0341. bsi:BS1330_II0338.
PATRIC	17793481. VBIBruSui107850_2557.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG149939.
HOGENOM	HOG000125826.
OMA	VESEWEK.
ProtClustDB	PRK10208.
Family and domain databases
Gene3D	1.10.890.10. 1 hit.
HAMAP	MF_00946. HdeA.
InterPro	IPR024972. HNS-dep_expression_A. IPR010486. HNS-dep_expression_A/B. [Graphical view]
Pfam	PF06411. HdeA. 1 hit. [Graphical view]
PIRSF	PIRSF009564. HNS-dep_expression_A. 1 hit.
ProDom	PD065392. HNS-dep_expression_A. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47752. HNS-dep_expression_A. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HDEA_BRUSU

Accession

Primary (citable) accession number: Q8FWV4
Secondary accession number(s): G0KC80

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program