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Protein

Probable acid stress chaperone HdeA

Gene

hdeA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.UniRule annotation

GO - Biological processi

  1. cellular response to acidic pH Source: InterPro
  2. cellular response to stress Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acid stress chaperone HdeAUniRule annotation
Gene namesi
Name:hdeAUniRule annotation
Ordered Locus Names:BRA0341, BS1330_II0338
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

Subcellular locationi

Periplasm UniRule annotation

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626UniRule annotationAdd
BLAST
Chaini27 – 11488Probable acid stress chaperone HdeAPRO_0000338637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 94UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi204722.BRA0341.

Structurei

3D structure databases

ProteinModelPortaliQ8FWV4.
SMRiQ8FWV4. Positions 38-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HdeA family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG149939.
HOGENOMiHOG000125826.
OMAiCEDFLVI.
OrthoDBiEOG6Q2SQ4.

Family and domain databases

Gene3Di1.10.890.10. 1 hit.
HAMAPiMF_00946. HdeA.
InterProiIPR024972. HdeA.
IPR010486. HNS-dep_expression_A/B.
[Graphical view]
PfamiPF06411. HdeA. 1 hit.
[Graphical view]
PIRSFiPIRSF009564. HNS-dep_expression_A. 1 hit.
ProDomiPD065392. HNS-dep_expression_A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47752. SSF47752. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8FWV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKALFNKNT ALAAVTILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN
60 70 80 90 100
GLEESFKPTV VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA
110
SFWKKAEAEL KKVF
Length:114
Mass (Da):12,362
Last modified:March 1, 2003 - v1
Checksum:iEA4B34293EF0B73E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33539.1.
CP002998 Genomic DNA. Translation: AEM19818.1.
RefSeqiNP_699534.1. NC_004311.2.
YP_005614044.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33539; AAN33539; BRA0341.
AEM19818; AEM19818; BS1330_II0338.
GeneIDi1164779.
12139773.
KEGGibms:BRA0341.
bsi:BS1330_II0338.
PATRICi17793481. VBIBruSui107850_2557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN33539.1.
CP002998 Genomic DNA. Translation: AEM19818.1.
RefSeqiNP_699534.1. NC_004311.2.
YP_005614044.1. NC_017250.1.

3D structure databases

ProteinModelPortaliQ8FWV4.
SMRiQ8FWV4. Positions 38-113.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BRA0341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN33539; AAN33539; BRA0341.
AEM19818; AEM19818; BS1330_II0338.
GeneIDi1164779.
12139773.
KEGGibms:BRA0341.
bsi:BS1330_II0338.
PATRICi17793481. VBIBruSui107850_2557.

Phylogenomic databases

eggNOGiNOG149939.
HOGENOMiHOG000125826.
OMAiCEDFLVI.
OrthoDBiEOG6Q2SQ4.

Miscellaneous databases

PROiQ8FWV4.

Family and domain databases

Gene3Di1.10.890.10. 1 hit.
HAMAPiMF_00946. HdeA.
InterProiIPR024972. HdeA.
IPR010486. HNS-dep_expression_A/B.
[Graphical view]
PfamiPF06411. HdeA. 1 hit.
[Graphical view]
PIRSFiPIRSF009564. HNS-dep_expression_A. 1 hit.
ProDomiPD065392. HNS-dep_expression_A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47752. SSF47752. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiHDEA_BRUSU
AccessioniPrimary (citable) accession number: Q8FWV4
Secondary accession number(s): G0KC80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.