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Q8FWV4

- HDEA_BRUSU

UniProt

Q8FWV4 - HDEA_BRUSU

Protein

Probable acid stress chaperone HdeA

Gene

hdeA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.UniRule annotation

    GO - Biological processi

    1. cellular response to acidic pH Source: InterPro
    2. cellular response to stress Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable acid stress chaperone HdeAUniRule annotation
    Gene namesi
    Name:hdeAUniRule annotation
    Ordered Locus Names:BRA0341, BS1330_II0338
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    Subcellular locationi

    Periplasm UniRule annotation

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626UniRule annotationAdd
    BLAST
    Chaini27 – 11488Probable acid stress chaperone HdeAPRO_0000338637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 94UniRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BRA0341.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FWV4.
    SMRiQ8FWV4. Positions 38-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HdeA family.UniRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG149939.
    HOGENOMiHOG000125826.
    OMAiLIAEECR.
    OrthoDBiEOG6Q2SQ4.

    Family and domain databases

    Gene3Di1.10.890.10. 1 hit.
    HAMAPiMF_00946. HdeA.
    InterProiIPR024972. HdeA.
    IPR010486. HNS-dep_expression_A/B.
    [Graphical view]
    PfamiPF06411. HdeA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009564. HNS-dep_expression_A. 1 hit.
    ProDomiPD065392. HNS-dep_expression_A. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF47752. SSF47752. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8FWV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKALFNKNT ALAAVTILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN    50
    GLEESFKPTV VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA 100
    SFWKKAEAEL KKVF 114
    Length:114
    Mass (Da):12,362
    Last modified:March 1, 2003 - v1
    Checksum:iEA4B34293EF0B73E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33539.1.
    CP002998 Genomic DNA. Translation: AEM19818.1.
    RefSeqiNP_699534.1. NC_004311.2.
    YP_005614044.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN33539; AAN33539; BRA0341.
    AEM19818; AEM19818; BS1330_II0338.
    GeneIDi1164779.
    12139773.
    KEGGibms:BRA0341.
    bsi:BS1330_II0338.
    PATRICi17793481. VBIBruSui107850_2557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33539.1 .
    CP002998 Genomic DNA. Translation: AEM19818.1 .
    RefSeqi NP_699534.1. NC_004311.2.
    YP_005614044.1. NC_017250.1.

    3D structure databases

    ProteinModelPortali Q8FWV4.
    SMRi Q8FWV4. Positions 38-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA0341.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN33539 ; AAN33539 ; BRA0341 .
    AEM19818 ; AEM19818 ; BS1330_II0338 .
    GeneIDi 1164779.
    12139773.
    KEGGi bms:BRA0341.
    bsi:BS1330_II0338.
    PATRICi 17793481. VBIBruSui107850_2557.

    Phylogenomic databases

    eggNOGi NOG149939.
    HOGENOMi HOG000125826.
    OMAi LIAEECR.
    OrthoDBi EOG6Q2SQ4.

    Miscellaneous databases

    PROi Q8FWV4.

    Family and domain databases

    Gene3Di 1.10.890.10. 1 hit.
    HAMAPi MF_00946. HdeA.
    InterProi IPR024972. HdeA.
    IPR010486. HNS-dep_expression_A/B.
    [Graphical view ]
    Pfami PF06411. HdeA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009564. HNS-dep_expression_A. 1 hit.
    ProDomi PD065392. HNS-dep_expression_A. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF47752. SSF47752. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiHDEA_BRUSU
    AccessioniPrimary (citable) accession number: Q8FWV4
    Secondary accession number(s): G0KC80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3