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Q8FWV4 (HDEA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable acid stress chaperone HdeA
Gene names
Name:hdeA
Ordered Locus Names:BRA0341, BS1330_II0338
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length114 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins By similarity. HAMAP-Rule MF_00946

Subcellular location

Periplasm By similarity HAMAP-Rule MF_00946.

Sequence similarities

Belongs to the HdeA family.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionChaperone
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular response to acidity

Inferred from electronic annotation. Source: InterPro

cellular response to stress

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 11488Probable acid stress chaperone HdeA HAMAP-Rule MF_00946
PRO_0000338637

Amino acid modifications

Disulfide bond46 ↔ 94 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FWV4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EA4B34293EF0B73E

FASTA11412,362
        10         20         30         40         50         60 
MIKALFNKNT ALAAVTILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN GLEESFKPTV 

        70         80         90        100        110 
VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA SFWKKAEAEL KKVF 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014292 Genomic DNA. Translation: AAN33539.1.
CP002998 Genomic DNA. Translation: AEM19818.1.
RefSeqNP_699534.1. NC_004311.2.
YP_005614044.1. NC_017250.1.

3D structure databases

ProteinModelPortalQ8FWV4.
SMRQ8FWV4. Positions 38-113.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BRA0341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN33539; AAN33539; BRA0341.
AEM19818; AEM19818; BS1330_II0338.
GeneID1164779.
12139773.
KEGGbms:BRA0341.
bsi:BS1330_II0338.
PATRIC17793481. VBIBruSui107850_2557.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG149939.
HOGENOMHOG000125826.
OMALIAEECR.
OrthoDBEOG6Q2SQ4.

Family and domain databases

Gene3D1.10.890.10. 1 hit.
HAMAPMF_00946. HdeA.
InterProIPR024972. HdeA.
IPR010486. HNS-dep_expression_A/B.
[Graphical view]
PfamPF06411. HdeA. 1 hit.
[Graphical view]
PIRSFPIRSF009564. HNS-dep_expression_A. 1 hit.
ProDomPD065392. HNS-dep_expression_A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF47752. SSF47752. 1 hit.
ProtoNetSearch...

Other

PROQ8FWV4.

Entry information

Entry nameHDEA_BRUSU
AccessionPrimary (citable) accession number: Q8FWV4
Secondary accession number(s): G0KC80
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names