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Q8FWN5

- NANEK_BRUSU

UniProt

Q8FWN5 - NANEK_BRUSU

Protein

Bifunctional enzyme NanE/NanK

Gene

nanEK

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).Curated
    Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.By similarity

    Catalytic activityi

    N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate.
    ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2538ATPSequence Analysis
    Nucleotide bindingi372 – 3798ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. N-acylglucosamine-6-phosphate 2-epimerase activity Source: UniProtKB-EC
    3. N-acylmannosamine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. N-acetylmannosamine metabolic process Source: InterPro
    2. N-acetylneuraminate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase, Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00629; UER00681.
    UPA00629; UER00682.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional enzyme NanE/NanK
    Including the following 2 domains:
    Putative N-acetylmannosamine-6-phosphate 2-epimerase (EC:5.1.3.9)
    Alternative name(s):
    ManNAc-6-P epimerase
    N-acetylmannosamine kinase (EC:2.7.1.60)
    Alternative name(s):
    ManNAc kinase
    N-acetyl-D-mannosamine kinase
    Gene namesi
    Name:nanEK
    Ordered Locus Names:BRA0411, BS1330_II0408
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Bifunctional enzyme NanE/NanKPRO_0000179824Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BRA0411.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FWN5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 241241ManNAc-6-P epimeraseAdd
    BLAST
    Regioni242 – 525284ManNAc kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the NanE family.Curated
    In the C-terminal section; belongs to the ROK (NagC/XylR) family. NanK subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000289284.
    KOiK13967.
    OMAiREDIANC.
    OrthoDBiEOG6NSGKX.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01235. ManNAc6P_epimer.
    InterProiIPR013785. Aldolase_TIM.
    IPR007260. NanE.
    IPR011060. RibuloseP-bd_barrel.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF04131. NanE. 1 hit.
    PF00480. ROK. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FWN5-1 [UniParc]FASTAAdd to Basket

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    MRGSPRNLCR VQGMIEEIVN RLRGKLIVSC QPVPESPFDN VASVVAYARA    50
    AEASGASGLR IEGAANVAAT AQASTLPVIG LIKRDLDDSP VRITPFLEDV 100
    AALCDAGAAI VAVDATDRRR PVPAAELIGE IKRRGRIAMA DISTLAEARN 150
    ALAAGADIIG TTMSGYTGEG PTPKDPDLDL VAHCSRLGSF LIAEGRYNSP 200
    QQAGEAIRAG ADAVVVGSAI TRPEHITGWF RDAVESAAKP SSPVLAFDIG 250
    GTKTLAALVR GREILERRVM TTPASVGSES WIGAIASLSA DWQGRYQRAA 300
    IAVTGRVDGE IWSSLNPETL AIPPDYPLGR RMGAALGAPV EVINDAQAAA 350
    WGENRFGAAR GRDMVFLTIS SGIGGGIVLG GRLIRGARGI AGSLGQVLVA 400
    GPSGFVRLET LASGFGIAKM ALEAGHAGDA RSVFSAAAAG EGWARRILLD 450
    AASQLAAAVA GLQAIVDPEC IVIGGGVGMA DGFLDMLREA LGSHSAVMRP 500
    DIVAAELGAD AGIIGVADLA ATYFS 525
    Length:525
    Mass (Da):53,867
    Last modified:March 1, 2003 - v1
    Checksum:iD403CAE499AB9486
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33608.1.
    CP002998 Genomic DNA. Translation: AEM19887.1.
    RefSeqiNP_699603.1. NC_004311.2.
    YP_005614113.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN33608; AAN33608; BRA0411.
    AEM19887; AEM19887; BS1330_II0408.
    GeneIDi1164849.
    12139843.
    KEGGibms:BRA0411.
    bsi:BS1330_II0408.
    PATRICi17793616. VBIBruSui107850_2624.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN33608.1 .
    CP002998 Genomic DNA. Translation: AEM19887.1 .
    RefSeqi NP_699603.1. NC_004311.2.
    YP_005614113.1. NC_017250.1.

    3D structure databases

    ProteinModelPortali Q8FWN5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA0411.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN33608 ; AAN33608 ; BRA0411 .
    AEM19887 ; AEM19887 ; BS1330_II0408 .
    GeneIDi 1164849.
    12139843.
    KEGGi bms:BRA0411.
    bsi:BS1330_II0408.
    PATRICi 17793616. VBIBruSui107850_2624.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000289284.
    KOi K13967.
    OMAi REDIANC.
    OrthoDBi EOG6NSGKX.

    Enzyme and pathway databases

    UniPathwayi UPA00629 ; UER00681 .
    UPA00629 ; UER00682 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01235. ManNAc6P_epimer.
    InterProi IPR013785. Aldolase_TIM.
    IPR007260. NanE.
    IPR011060. RibuloseP-bd_barrel.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF04131. NanE. 1 hit.
    PF00480. ROK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiNANEK_BRUSU
    AccessioniPrimary (citable) accession number: Q8FWN5
    Secondary accession number(s): G0KCE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3