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Q8FW95

- BFR_BRUSU

UniProt

Q8FW95 - BFR_BRUSU

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Protein
Bacterioferritin
Gene
bfr, BRA0565, BS1330_II0560
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Cofactori

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181Iron 1 By similarity
Metal bindingi51 – 511Iron 1 By similarity
Metal bindingi51 – 511Iron 2 By similarity
Metal bindingi52 – 521Iron (heme axial ligand); shared with dimeric partner By similarity
Metal bindingi54 – 541Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi127 – 1271Iron 1 By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi130 – 1301Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Bacterioferritin (EC:1.16.3.1)
Short name:
BFR
Gene namesi
Name:bfr
Ordered Locus Names:BRA0565, BS1330_II0560
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161Bacterioferritin
PRO_0000192590Add
BLAST

Interactioni

Subunit structurei

Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited By similarity.

Protein-protein interaction databases

STRINGi204722.BRA0565.

Structurei

3D structure databases

ProteinModelPortaliQ8FW95.
SMRiQ8FW95. Positions 1-160.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Belongs to the bacterioferritin family.

Phylogenomic databases

eggNOGiCOG2193.
HOGENOMiHOG000262383.
KOiK03594.
OMAiAGDYVSM.
OrthoDBiEOG6WDSKP.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
PIRSFiPIRSF002560. Bacterioferritin. 1 hit.
PRINTSiPR00601. BACFERRITIN.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR00754. bfr. 1 hit.
PROSITEiPS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FW95-1 [UniParc]FASTAAdd to Basket

« Hide

MKGEPKVIER LNEALFLELG AVNQYWLHYR LLNDWGYTRL AKKEREESIE    50
EMHHADKLID RIIFLEGFPN LQTVSPLRIG QNVKEVLEAD LKGEYDARAS 100
YKESREICDK LGDYVSKQLF DELLADEEGH IDFLETQLDL LAKIGEERYG 150
QLNAAPADEA E 161
Length:161
Mass (Da):18,640
Last modified:March 1, 2003 - v1
Checksum:i1D30A44BE843DDCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN33754.1.
CP002998 Genomic DNA. Translation: AEM20031.1.
RefSeqiNP_699749.1. NC_004311.2.
YP_005614257.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33754; AAN33754; BRA0565.
AEM20031; AEM20031; BS1330_II0560.
GeneIDi1165004.
12139996.
KEGGibms:BRA0565.
bsi:BS1330_II0560.
PATRICi17793933. VBIBruSui107850_2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN33754.1 .
CP002998 Genomic DNA. Translation: AEM20031.1 .
RefSeqi NP_699749.1. NC_004311.2.
YP_005614257.1. NC_017250.1.

3D structure databases

ProteinModelPortali Q8FW95.
SMRi Q8FW95. Positions 1-160.
ModBasei Search...

Protein-protein interaction databases

STRINGi 204722.BRA0565.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN33754 ; AAN33754 ; BRA0565 .
AEM20031 ; AEM20031 ; BS1330_II0560 .
GeneIDi 1165004.
12139996.
KEGGi bms:BRA0565.
bsi:BS1330_II0560.
PATRICi 17793933. VBIBruSui107850_2781.

Phylogenomic databases

eggNOGi COG2193.
HOGENOMi HOG000262383.
KOi K03594.
OMAi AGDYVSM.
OrthoDBi EOG6WDSKP.

Miscellaneous databases

PROi Q8FW95.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR002024. Bacterioferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002560. Bacterioferritin. 1 hit.
PRINTSi PR00601. BACFERRITIN.
SUPFAMi SSF47240. SSF47240. 1 hit.
TIGRFAMsi TIGR00754. bfr. 1 hit.
PROSITEi PS00549. BACTERIOFERRITIN. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiBFR_BRUSU
AccessioniPrimary (citable) accession number: Q8FW95
Secondary accession number(s): G0KCU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi