Reviewed, UniProtKB/Swiss-Prot Q8FW95 (BFR_BRUSU)

Names and origin

Protein names

Recommended name:
    Bacterioferritin
      Short name=BFR

Gene names

Name:	bfr
Ordered Locus Names:	BRA0565

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May perform analogous functions in iron detoxification and storage to that of animal ferritins.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity.
Subunit structure	Oligomer of 24 identical subunits By similarity.
Miscellaneous	The di-iron binding site functions as active site where iron ions are oxidized from Fe2+ to Fe3+ before they are stored By similarity.
Sequence similarities	Belongs to the bacterioferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Molecular function	ferric iron binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	Bacterioferritin		PRO_0000192590
Regions
	Domain	1 – 145	145	Ferritin-like diiron
Sites
	Metal binding	18	1	Iron 1 By similarity
	Metal binding	51	1	Iron 1 By similarity
	Metal binding	51	1	Iron 2 By similarity
	Metal binding	52	1	Iron (heme axial ligand) By similarity
	Metal binding	54	1	Iron 1 By similarity
	Metal binding	94	1	Iron 2 By similarity
	Metal binding	127	1	Iron 1 By similarity
	Metal binding	127	1	Iron 2 By similarity
	Metal binding	130	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FW95-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1D30A44BE843DDCE	FASTA	161	18,640
	10 20 30 40 50 60 MKGEPKVIER LNEALFLELG AVNQYWLHYR LLNDWGYTRL AKKEREESIE EMHHADKLID 70 80 90 100 110 120 RIIFLEGFPN LQTVSPLRIG QNVKEVLEAD LKGEYDARAS YKESREICDK LGDYVSKQLF 130 140 150 160 DELLADEEGH IDFLETQLDL LAKIGEERYG QLNAAPADEA E

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014292 Genomic DNA. Translation: AAN33754.1.
RefSeq	NP_699749.1.
3D structure databases
HSSP	HSSP built from PDB template 1BCF based on UniProtKB P11056.
ModBase	Search...
Genome annotation databases
GeneID	1165004.
GenomeReviews	Gene locus BRA0565 in contig AE014292_GR.
KEGG	bms:BRA0565.
NMPDR	fig|204722.1.peg.2658.
TIGR	BRA0565.
Phylogenomic databases
HOGENOM	Q8FW95.
OMA	WRKESIE.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_A0565-MON.
Family and domain databases
InterPro	IPR002024. Bacterioferritin. IPR009040. Ferritin-like. IPR008331. Ferritin_Dps. IPR012347. Ferritin_rel. [Graphical view]
Gene3D	G3DSA:1.20.1260.10. Ferritin_rel. 1 hit.
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
PIRSF	PIRSF002560. Bacterioferritin. 1 hit.
PRINTS	PR00601. BACFERRITIN.
ProDom	PD002269. Bacterioferritin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00754. bfr. 1 hit.
PROSITE	PS00549. BACTERIOFERRITIN. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BFR_BRUSU

Accession

Primary (citable) accession number: Q8FW95

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)