Q8FW59 (Q8FW59_BRUSU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ribonuclease R HAMAP-Rule MF_01895
Short name=RNase R HAMAP-Rule MF_01895
EC=3.1.13.1 HAMAP-Rule MF_01895

Gene names

Name:	rnr HAMAP-Rule MF_01895
Ordered Locus Names:	BRA0605, BS1330_II0600 EMBL AEM20071.1

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP] EMBL AAN33794.1

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	783 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs By similarity. HAMAP-Rule MF_01895
Catalytic activity	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. SAAS SAAS022966 HAMAP-Rule MF_01895
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_01895.
Sequence similarities	Belongs to the RNR ribonuclease family. RNase R subfamily. HAMAP-Rule MF_01895 Contains 1 S1 motif domain. SAAS SAAS022966 HAMAP-Rule MF_01895

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS022966 HAMAP-Rule MF_01895
Ligand	RNA-binding SAAS SAAS022966 RuleBase RU003902 HAMAP-Rule MF_01895
Molecular function	Exonuclease SAAS SAAS022966 RuleBase RU003902 HAMAP-Rule MF_01895 Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	RNA metabolic process Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: HAMAP exoribonuclease II activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Domain	664 – 745	82	S1 motif By similarity HAMAP-Rule MF_01895

Sequences

	Sequence		Length	Mass (Da)
	Q8FW59 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 19207F19F5834477	FASTA	783	86,749
	10 20 30 40 50 60 MARRFSKSDT GRSARTERRA ATAQSKDSAA FLPTREEVLK YIEENPDRAG KRELAKAFNI 70 80 90 100 110 120 EGDARVYLKD LLRELADEGL VEKRARKLSR PGSLPSVAVL DITGRDEDGG LLARPAEWVE 130 140 150 160 170 180 ASHGKPPVVL LRRTRLNKTS ESGPVVGVGD RVLAKIFRNE DHAGPDFSAR VMKRLEHHAN 190 200 210 220 230 240 AVLGVVRKLG NGEWRLEPVN RKQGEVQLDP AMLENAESGD LVEVELLSAR RYGLPRGKVR 250 260 270 280 290 300 QVVGSIDSEK ALSMIAIHEH EIPHVFPDEV LREAETAGPA TLEGREDWRE IPLITIDPAD 310 320 330 340 350 360 AKDHDDAVYA EPDTDPENPG GQVVIVAITD VAAYVRPGSA LDREAQKRGN SVYFPDRVVP 370 380 390 400 410 420 MLPERISNDL CSLREMEDRP ALTVRMIFSA DGRKKSHKFH RIMMRSAAKV AYGQAQAAID 430 440 450 460 470 480 GAPDDKTGPI LDTVLKPLWS AYAVLKRGRD AREPLELDLP EKKILLTPEG KVDKVIVPER 490 500 510 520 530 540 LDAHKLIEEF MIQANVSAAE TLEGRHQPLI FRIHGEPALA KQETLREFLR TLDLNLAKGA 550 560 570 580 590 600 QLQPAQFNRI LAAVDGTDHQ ELVNQVVLRT QSQAEYSPDN IGHFGLHLRR YAHFTSPIRR 610 620 630 640 650 660 YADLIVHRAL IKALGLGTDG LTSAEEAQLE EISALISATE RRAMLAERET VDRLIAHFLA 670 680 690 700 710 720 SHLGDEYEGR VTGVTRAGLF VNLATYGADG LVPISTLGHE YYLYDEANHA IAGERSGRGF 730 740 750 760 770 780 RLGDTVTVRL VEALPVAGAL RFEMVSEPHP LPMSTRSHHK ASRAMRGRKG KPAGIPRHKR RGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.
[2]	"Revised Genome Sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) Cited for: NUCLEOTIDE SEQUENCE. Strain: 1330 EMBL AEM20071.1.
[3]	"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014292 Genomic DNA. Translation: AAN33794.1. CP002998 Genomic DNA. Translation: AEM20071.1.
RefSeq	NP_699789.1. NC_004311.2. YP_005614297.1. NC_017250.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BRA0605.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN33794; AAN33794; BRA0605. AEM20071; AEM20071; BS1330_II0600.
GeneID	1165045. 12138826.
KEGG	bms:BRA0605. bsi:BS1330_II0600.
PATRIC	17794017. VBIBruSui107850_2822.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000071121.
KO	K12573.
OMA	NLRRYAH.
ProtClustDB	CLSK863104.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
HAMAP	MF_01895. RNase_R.
InterPro	IPR012340. NA-bd_OB-fold. IPR003029. Rbsml_prot_S1_RNA-bd_dom. IPR022967. RNA-binding_domain_S1. IPR001900. RNase_II/R. IPR022966. RNase_II/R_CS. IPR004476. RNase_II/RNase_R. IPR011805. RNase_R. [Graphical view]
Pfam	PF00773. RNB. 1 hit. PF00575. S1. 1 hit. [Graphical view]
SMART	SM00955. RNB. 1 hit. SM00316. S1. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00358. 3_prime_RNase. 1 hit. TIGR02063. RNase_R. 1 hit.
PROSITE	PS01175. RIBONUCLEASE_II. 1 hit. PS50126. S1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8FW59_BRUSU

Accession

Primary (citable) accession number: Q8FW59

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)