SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8FVU9

- GCSP_BRUSU

UniProt

Q8FVU9 - GCSP_BRUSU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, BRA0725, BS1330_II0718
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BRA0725, BS1330_II0718
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 932932Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei685 – 6851N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi204722.BRA0725.

Structurei

3D structure databases

ProteinModelPortaliQ8FVU9.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FVU9-1 [UniParc]FASTAAdd to Basket

« Hide

MTEFLPFVAR HIGPRHEDER AMLAALGLPS METLITQAVP ASIRLNRALN    50
LPAALSEADA LAELGTIMGR NVVKKSFIGA GYHGVHTPPV IQRNLFENPA 100
WYTAYTPYQS EISQGRLELL FHFQTLVAEL TGLPVACASL LDEATAVAEA 150
IGVACRHHRD KRSRILLAGE LHPQTVDVVN TRAEPLGWEI ATGSDVDDNT 200
AAIVVPWPDT RGVYGDFAKV IADAKAKGAL VIAVADPLAL TIMEAPARWG 250
ADMAVGSMQR YGVPMGFGGP HAAYLAVSEA LTRIIPGRIV GQSVDAHGRA 300
AYRLALQTRE QHIRRDKATS NICTAQALLA NMAAAFAIWH GPAGLQAIAT 350
RVAALAARFA AALKAAGVEI AGESLFDTVT AKVPGKAAAI AAEADKGGRL 400
IRIIDADTVG VTFDETSTEE DLTALASLFG AKPVGGDTVL VPGKERGEGF 450
LTQEVFHSHR SETEMMRFLR RLADKDLALD RAMIPLGSCT MKLNAAAEMM 500
PVSWNTVANL HPFAPAEQVQ GYAKMTSDLE AWLCEITGFA GVSLQPNAGS 550
QGEYAGLMAI RHYHQAWGQG HRNICLIPSS AHGTNPASAS MAGMSVVVVN 600
CRPDGDIDID DLKAKAEKHR DNLAAFMITY PSTYGVFEEG IKAFCEIVHD 650
NGGQVYFDGA NLNALVGLAR PADIGADVCH MNLHKTFCIP HGGGGPGVGP 700
IGVAKHLVPY LPGHVEAGSE HAVAAAQFGS ASILVITWMY IRMMGGAGLK 750
KATEAAILNA NYIAHRLKGV YPILYTGAHD RVAHECIVDT RVLKDSAGIT 800
VEDVAKRLID YGFHAPTMSW PVAGTLMIEP TESEPKLEID RLCDAMIAIA 850
GEAKKVADGV WPADDNPLAN APHTASDTLA TEWKHPYTRE EAVFPGGAFD 900
PTAKYWPPVS RVDNVGGDRN LICSCPPVAA YG 932
Length:932
Mass (Da):99,254
Last modified:March 1, 2003 - v1
Checksum:iE3889FEE67C92252
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN33907.1.
CP002998 Genomic DNA. Translation: AEM20183.1.
RefSeqiNP_699902.1. NC_004311.2.
YP_005614409.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN33907; AAN33907; BRA0725.
AEM20183; AEM20183; BS1330_II0718.
GeneIDi1165167.
12138946.
KEGGibms:BRA0725.
bsi:BS1330_II0718.
PATRICi17794258. VBIBruSui107850_2940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN33907.1 .
CP002998 Genomic DNA. Translation: AEM20183.1 .
RefSeqi NP_699902.1. NC_004311.2.
YP_005614409.1. NC_017250.1.

3D structure databases

ProteinModelPortali Q8FVU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BRA0725.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN33907 ; AAN33907 ; BRA0725 .
AEM20183 ; AEM20183 ; BS1330_II0718 .
GeneIDi 1165167.
12138946.
KEGGi bms:BRA0725.
bsi:BS1330_II0718.
PATRICi 17794258. VBIBruSui107850_2940.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Miscellaneous databases

PROi Q8FVU9.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiGCSP_BRUSU
AccessioniPrimary (citable) accession number: Q8FVU9
Secondary accession number(s): G0KD95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi