Q8FVE4 (OCD_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine cyclodeaminase
Short name=OCD
EC=4.3.1.12

Gene names

Name:	arcB
Ordered Locus Names:	BRA0899, BS1330_II0891

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-ornithine = L-proline + NH3.
Cofactor	NAD.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-ornithine: step 1/1.
Sequence similarities	Belongs to the ornithine cyclodeaminase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro ornithine cyclodeaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Ornithine cyclodeaminase		PRO_0000200672

Sequences

	Sequence		Length	Mass (Da)
	Q8FVE4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DA2F02B1171B4C81	FASTA	358	39,299
	10 20 30 40 50 60 MTQPNLNIVP FVSVDHMMKL VLRVGVETFL KELAGYVEED FRRWQNFDKT PRVASHSKEG 70 80 90 100 110 120 VIELMPTSDG TLYGFKYVNG HPKNTRDGLQ TVTAFGVLAN VGSGYPMLLT EMTILTALRT 130 140 150 160 170 180 AATSAVAAKH LAPKNARTMA IIGNGAQSEF QALAFKAILG VDKLRLYDLD PQATAKCIRN 190 200 210 220 230 240 LQGAGFDIVA CKSVEEAVEG ADIITTVTAD KANATILTDN MVGAGVHINA VGGDCPGKTE 250 260 270 280 290 300 LHGDILRRSD IFVEYPPQTR IEGEIQQLPE DYPVNELWEV ITGRIAGRKD ARQITLFDSV 310 320 330 340 350 GFATEDFSAL RYVRDKLKDT GLYEQLDLLA DPDEPRDLYG MLLRHEKLLQ SESTKPAA

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014292 Genomic DNA. Translation: AAN34071.1. CP002998 Genomic DNA. Translation: AEM20347.1.
RefSeq	NP_700066.1. NC_004311.2. YP_005614573.1. NC_017250.1.
3D structure databases
ProteinModelPortal	Q8FVE4.
SMR	Q8FVE4. Positions 11-339.
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BRA0899.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN34071; AAN34071; BRA0899. AEM20347; AEM20347; BS1330_II0891.
GeneID	1165343. 12139121.
KEGG	bms:BRA0899. bsi:BS1330_II0891.
PATRIC	17794617. VBIBruSui107850_3117.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2423.
HOGENOM	HOG000137262.
KO	K01750.
OMA	HINAIGG.
ProtClustDB	PRK07589.
Enzyme and pathway databases
UniPathway	UPA00098; UER00357.
Family and domain databases
Gene3D	3.30.1780.10. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR016040. NAD(P)-bd_dom. IPR003462. ODC_Mu_crystall. IPR023401. ODC_N. [Graphical view]
Pfam	PF02423. OCD_Mu_crystall. 1 hit. [Graphical view]
PIRSF	PIRSF001439. CryM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OCD_BRUSU

Accession

Primary (citable) accession number: Q8FVE4
Secondary accession number(s): G0KDQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program