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Q8FVC1

- ALR_BRUSU

UniProt

Q8FVC1 - ALR_BRUSU

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Protein

Alanine racemase

Gene
alr, BRA0923, BS1330_II0915
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461Proton acceptor; specific for D-alanine By similarity
Binding sitei145 – 1451Substrate By similarity
Active sitei280 – 2801Proton acceptor; specific for L-alanine By similarity
Binding sitei328 – 3281Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase (EC:5.1.1.1)
Gene namesi
Name:alr
Ordered Locus Names:BRA0923, BS1330_II0915
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Alanine racemaseUniRule annotationPRO_0000114504Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei46 – 461N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi204722.BRA0923.

Structurei

3D structure databases

ProteinModelPortaliQ8FVC1.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031445.
KOiK01775.
OMAiIYSHLAL.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FVC1-1 [UniParc]FASTAAdd to Basket

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MSLPFSQDER DLAAGGILTI DLAALRHNYS AIATRIAPTR TAAVVKADAY    50
GLGASRVAPA FYEAGCRDFF VAHLGEAVAL KPFLKPDATL YVLNGLQPGT 100
EAACAREGIL PVLNSLEQVE NWAALATRLG KKLPALLQFD TGMSRLGLSA 150
KEFDRLLENV TLLSRIDIKF AISHLANGDE PGNAANARQL AKMTALLARL 200
PKLPAALANS GGTFLGKTYY FDLARPGIAL YGIDPERQHD FSDKVAHENK 250
KPKHSILPVL TLSARVIQVR DVDKGATVGY GGTYVANGPM RIATIAVGYA 300
DGLFRSLSNK GAAFFGDTRL PIIGRVSMDS ITLDVTSLPE GTLKLGSLVE 350
LIGPHQRLED VARDCDTIPY EILTALGNRY ARVYVYVNGG GTSTTA 396
Length:396
Mass (Da):42,340
Last modified:March 1, 2003 - v1
Checksum:iC24971EE273E8622
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN34095.1.
CP002998 Genomic DNA. Translation: AEM20371.1.
RefSeqiNP_700090.1. NC_004311.2.
YP_005614597.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN34095; AAN34095; BRA0923.
AEM20371; AEM20371; BS1330_II0915.
GeneIDi1165367.
12139146.
KEGGibms:BRA0923.
bsi:BS1330_II0915.
PATRICi17794663. VBIBruSui107850_3140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014292 Genomic DNA. Translation: AAN34095.1 .
CP002998 Genomic DNA. Translation: AEM20371.1 .
RefSeqi NP_700090.1. NC_004311.2.
YP_005614597.1. NC_017250.1.

3D structure databases

ProteinModelPortali Q8FVC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BRA0923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN34095 ; AAN34095 ; BRA0923 .
AEM20371 ; AEM20371 ; BS1330_II0915 .
GeneIDi 1165367.
12139146.
KEGGi bms:BRA0923.
bsi:BS1330_II0915.
PATRICi 17794663. VBIBruSui107850_3140.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031445.
KOi K01775.
OMAi IYSHLAL.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiALR_BRUSU
AccessioniPrimary (citable) accession number: Q8FVC1
Secondary accession number(s): G0KDT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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