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Q8FV25 (DAPD_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

EC=2.3.1.117
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferase
Short name=THDP succinyltransferase
Short name=THP succinyltransferase
Short name=Tetrahydropicolinate succinylase
Gene names
Name:dapD
Ordered Locus Names:BRA1028, BS1330_II1020
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate. HAMAP-Rule MF_00811

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. HAMAP-Rule MF_00811

Subunit structure

Homotrimer By similarity. HAMAP-Rule MF_00811

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00811.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2842842,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase HAMAP-Rule MF_00811
PRO_0000196922

Sites

Binding site1111Substrate By similarity
Binding site1481Substrate By similarity

Secondary structure

......................................... 284
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8FV25 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 9EF76F51038A6350

FASTA28430,753
        10         20         30         40         50         60 
MTKPDLASLE KTIEKAFDER DGINTATRGE VREAVEQSLI LLDRGEVRVA EKQADGNWHV 

        70         80         90        100        110        120 
NQWLKKAVLL SFRLNPMEVI KGGPGQSSWW DKVPSKFDGW TANEFEKAGF RAVPNCIVRH 

       130        140        150        160        170        180 
SAYIAPNAIL MPSFVNLGAY VDKGAMIDTW ATVGSCAQIG KNVHLSGGVG IGGVLEPMQA 

       190        200        210        220        230        240 
GPTIIEDNCF IGARSEVVEG CIVREGSVLG MGVFIGKSTK IVDRATGEVF YGEVPPYSVV 

       250        260        270        280 
VAGTMPGKNV PGENWGPSLY CAVIVKRADE KTRSKTSINE LLRD 

« Hide

References

« Hide 'large scale' references
[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"Crystal structure of 2,3,4,5-tetrahydropyridine-2-carboxylate n-succinyltransferase from Brucella melitensis biovar abortus 2308."
Seattle structural genomics center for infectious disease (SSGCID)
Submitted (SEP-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014292 Genomic DNA. Translation: AAN34196.1.
CP002998 Genomic DNA. Translation: AEM20472.1.
PIRAD3543.
RefSeqNP_700191.1. NC_004311.2.
YP_005614698.1. NC_017250.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3EG4X-ray1.87A1-284[»]
ProteinModelPortalQ8FV25.
SMRQ8FV25. Positions 6-283.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BRA1028.

Proteomic databases

PRIDEQ8FV25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN34196; AAN34196; BRA1028.
AEM20472; AEM20472; BS1330_II1020.
GeneID1165473.
12139253.
KEGGbms:BRA1028.
bsi:BS1330_II1020.
PATRIC17794891. VBIBruSui107850_3253.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2171.
HOGENOMHOG000003295.
KOK00674.
OMAYIARNTV.
OrthoDBEOG68H8BV.

Enzyme and pathway databases

UniPathwayUPA00034; UER00019.

Family and domain databases

Gene3D1.10.166.10. 1 hit.
HAMAPMF_00811. DapD.
InterProIPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep_transf.
IPR018357. Hexapep_transf_CS.
IPR023180. THP_succinylTrfase_dom1.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PANTHERPTHR19136:SF52. PTHR19136:SF52. 1 hit.
PfamPF00132. Hexapep. 1 hit.
PF14805. THDPS_N_2. 1 hit.
[Graphical view]
SUPFAMSSF51161. SSF51161. 1 hit.
TIGRFAMsTIGR00965. dapD. 1 hit.
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8FV25.

Entry information

Entry nameDAPD_BRUSU
AccessionPrimary (citable) accession number: Q8FV25
Secondary accession number(s): G0KE34
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names