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Q8FV25

- DAPD_BRUSU

UniProt

Q8FV25 - DAPD_BRUSU

Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei111 – 1111SubstrateUniRule annotation
    Binding sitei148 – 1481SubstrateUniRule annotation

    GO - Molecular functioni

    1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00034; UER00019.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
    Alternative name(s):
    Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
    Short name:
    THDP succinyltransferaseUniRule annotation
    Short name:
    THP succinyltransferaseUniRule annotation
    Short name:
    Tetrahydropicolinate succinylaseUniRule annotation
    Gene namesi
    Name:dapDUniRule annotation
    Ordered Locus Names:BRA1028, BS1330_II1020
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2842842,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferasePRO_0000196922Add
    BLAST

    Proteomic databases

    PRIDEiQ8FV25.

    Interactioni

    Subunit structurei

    Homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BRA1028.

    Structurei

    Secondary structure

    1
    284
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 1812
    Helixi19 – 224
    Helixi29 – 4315
    Beta strandi49 – 524
    Beta strandi58 – 603
    Helixi62 – 7413
    Beta strandi78 – 814
    Helixi84 – 863
    Beta strandi88 – 925
    Turni96 – 994
    Helixi102 – 1087
    Beta strandi117 – 1193
    Beta strandi132 – 1354
    Beta strandi151 – 1533
    Beta strandi221 – 2233
    Turni224 – 2263
    Beta strandi232 – 2343
    Beta strandi238 – 2469
    Beta strandi258 – 26710
    Helixi270 – 2756
    Helixi278 – 2836

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EG4X-ray1.87A1-284[»]
    ProteinModelPortaliQ8FV25.
    SMRiQ8FV25. Positions 6-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8FV25.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transferase hexapeptide repeat family.UniRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG2171.
    HOGENOMiHOG000003295.
    KOiK00674.
    OMAiYIARNTV.
    OrthoDBiEOG68H8BV.

    Family and domain databases

    Gene3Di1.10.166.10. 1 hit.
    HAMAPiMF_00811. DapD.
    InterProiIPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view]
    PANTHERiPTHR19136:SF52. PTHR19136:SF52. 1 hit.
    PfamiPF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF51161. SSF51161. 1 hit.
    TIGRFAMsiTIGR00965. dapD. 1 hit.
    PROSITEiPS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FV25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKPDLASLE KTIEKAFDER DGINTATRGE VREAVEQSLI LLDRGEVRVA    50
    EKQADGNWHV NQWLKKAVLL SFRLNPMEVI KGGPGQSSWW DKVPSKFDGW 100
    TANEFEKAGF RAVPNCIVRH SAYIAPNAIL MPSFVNLGAY VDKGAMIDTW 150
    ATVGSCAQIG KNVHLSGGVG IGGVLEPMQA GPTIIEDNCF IGARSEVVEG 200
    CIVREGSVLG MGVFIGKSTK IVDRATGEVF YGEVPPYSVV VAGTMPGKNV 250
    PGENWGPSLY CAVIVKRADE KTRSKTSINE LLRD 284
    Length:284
    Mass (Da):30,753
    Last modified:March 1, 2003 - v1
    Checksum:i9EF76F51038A6350
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN34196.1.
    CP002998 Genomic DNA. Translation: AEM20472.1.
    PIRiAD3543.
    RefSeqiNP_700191.1. NC_004311.2.
    YP_005614698.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN34196; AAN34196; BRA1028.
    AEM20472; AEM20472; BS1330_II1020.
    GeneIDi1165473.
    12139253.
    KEGGibms:BRA1028.
    bsi:BS1330_II1020.
    PATRICi17794891. VBIBruSui107850_3253.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN34196.1 .
    CP002998 Genomic DNA. Translation: AEM20472.1 .
    PIRi AD3543.
    RefSeqi NP_700191.1. NC_004311.2.
    YP_005614698.1. NC_017250.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EG4 X-ray 1.87 A 1-284 [» ]
    ProteinModelPortali Q8FV25.
    SMRi Q8FV25. Positions 6-283.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA1028.

    Proteomic databases

    PRIDEi Q8FV25.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN34196 ; AAN34196 ; BRA1028 .
    AEM20472 ; AEM20472 ; BS1330_II1020 .
    GeneIDi 1165473.
    12139253.
    KEGGi bms:BRA1028.
    bsi:BS1330_II1020.
    PATRICi 17794891. VBIBruSui107850_3253.

    Phylogenomic databases

    eggNOGi COG2171.
    HOGENOMi HOG000003295.
    KOi K00674.
    OMAi YIARNTV.
    OrthoDBi EOG68H8BV.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00019 .

    Miscellaneous databases

    EvolutionaryTracei Q8FV25.

    Family and domain databases

    Gene3Di 1.10.166.10. 1 hit.
    HAMAPi MF_00811. DapD.
    InterProi IPR005664. DapD_Trfase_Hexpep_rpt_fam.
    IPR001451. Hexapep_transf.
    IPR018357. Hexapep_transf_CS.
    IPR023180. THP_succinylTrfase_dom1.
    IPR011004. Trimer_LpxA-like.
    [Graphical view ]
    PANTHERi PTHR19136:SF52. PTHR19136:SF52. 1 hit.
    Pfami PF00132. Hexapep. 1 hit.
    PF14805. THDPS_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51161. SSF51161. 1 hit.
    TIGRFAMsi TIGR00965. dapD. 1 hit.
    PROSITEi PS00101. HEXAPEP_TRANSFERASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    3. "Crystal structure of 2,3,4,5-tetrahydropyridine-2-carboxylate n-succinyltransferase from Brucella melitensis biovar abortus 2308."
      Seattle structural genomics center for infectious disease (SSGCID)
      Submitted (SEP-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS).

    Entry informationi

    Entry nameiDAPD_BRUSU
    AccessioniPrimary (citable) accession number: Q8FV25
    Secondary accession number(s): G0KE34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3