Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8FUZ2

- UPP_BRUSU

UniProt

Q8FUZ2 - UPP_BRUSU

Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (07 Nov 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 7815-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei103 – 10315-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei193 – 1931Uracil; via amide nitrogenUniRule annotation
    Binding sitei199 – 19915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. UMP salvage Source: UniProtKB-UniPathway
    2. uracil salvage Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00574; UER00636.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Alternative name(s):
    UMP pyrophosphorylaseUniRule annotation
    UPRTaseUniRule annotation
    Gene namesi
    Name:uppUniRule annotation
    Ordered Locus Names:BRA1067, BS1330_II1059
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome II, UP000007104: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Uracil phosphoribosyltransferasePRO_0000120807Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BRA1067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FUZ2.
    SMRiQ8FUZ2. Positions 2-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni130 – 13895-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
    Regioni198 – 2003Uracil bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the UPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0035.
    HOGENOMiHOG000262754.
    KOiK00761.
    OrthoDBiEOG6HF5WX.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01218_B. Upp_B.
    InterProiIPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01091. upp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FUZ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGVTVVSHPL VQHKLTIMRK KETSTASFQR LLKEISLLLC YEVTRNLELT    50
    TMSIETPLMP MEAPVLEGKK LVFASILRAG NGLLEGMLDL VPAARVAHIG 100
    LYRDHDTLQP IEYYFKAPED IVNRLVIVVD PMLATANSAI AAIDKLKERG 150
    ATNIRFLCLL AAPEGIERFT KAHPDVEVFT ASIDERLDEK GYIVPGLGDA 200
    GDRMYGTK 208
    Length:208
    Mass (Da):23,019
    Last modified:November 7, 2003 - v2
    Checksum:i2497D19976007987
    GO

    Sequence cautioni

    The sequence AAN34234.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN34234.1. Different initiation.
    CP002998 Genomic DNA. Translation: AEM20511.1.
    RefSeqiNP_700229.2. NC_004311.2.
    YP_005614737.1. NC_017250.1.

    Genome annotation databases

    EnsemblBacteriaiAAN34234; AAN34234; BRA1067.
    AEM20511; AEM20511; BS1330_II1059.
    GeneIDi1165513.
    12139294.
    KEGGibms:BRA1067.
    bsi:BS1330_II1059.
    PATRICi17794969. VBIBruSui107850_3291.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014292 Genomic DNA. Translation: AAN34234.1 . Different initiation.
    CP002998 Genomic DNA. Translation: AEM20511.1 .
    RefSeqi NP_700229.2. NC_004311.2.
    YP_005614737.1. NC_017250.1.

    3D structure databases

    ProteinModelPortali Q8FUZ2.
    SMRi Q8FUZ2. Positions 2-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BRA1067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN34234 ; AAN34234 ; BRA1067 .
    AEM20511 ; AEM20511 ; BS1330_II1059 .
    GeneIDi 1165513.
    12139294.
    KEGGi bms:BRA1067.
    bsi:BS1330_II1059.
    PATRICi 17794969. VBIBruSui107850_3291.

    Phylogenomic databases

    eggNOGi COG0035.
    HOGENOMi HOG000262754.
    KOi K00761.
    OrthoDBi EOG6HF5WX.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00636 .

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01218_B. Upp_B.
    InterProi IPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01091. upp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiUPP_BRUSU
    AccessioniPrimary (citable) accession number: Q8FUZ2
    Secondary accession number(s): G0KE73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3