Q8FUI4 (PKN2_COREF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinases drp72
EC=2.7.11.1

Gene names

Ordered Locus Names:

CE0034

Organism

Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]

Taxonomic identifier

196164 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium efficiens

Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 520	520	Serine/threonine-protein kinases drp72		PRO_0000171198
Regions
	Domain	20 – 281	262	Protein kinase
	Nucleotide binding	26 – 34	9	ATP By similarity
	Compositional bias	372 – 492	121	Pro/Thr-rich
Sites
	Active site	148	1	Proton acceptor By similarity
	Binding site	49	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FUI4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 84CC987FE9F902F9	FASTA	520	54,631
	10 20 30 40 50 60 MNTADDNAKQ RLQELIGPDY TLQWIVGHGG MSTVWLADDN VNDREVAVKV LRPEFSDNTE 70 80 90 100 110 120 FLSRFRNEAR AAENIHSEHV VTTYDYREVA DPAGHTFCFI VLEYIRGESL ADMLEREGAL 130 140 150 160 170 180 PEELALDVME QAAHGLSVIH RMGLVHRDIK PGNMLITANG ILKITDFGIA KAAASVPLTR 190 200 210 220 230 240 TGMVVGTAQY VSPEQAQGHQ VTPASDVYSL GVVGYEMLSG RRPFTGDSSV SVAIAHINEA 250 260 270 280 290 300 PPQMPTSVSA QARELIGIAL RKDPARRFAD GNELARAVSA VRLGNRPPQP HSPAVQATAV 310 320 330 340 350 360 APSPSASTAM LGQVARPTTS VPASPTVLPE RQEKRGSGVG LGLLIAAVIA AVIGGIIWAG 370 380 390 400 410 420 ATGVFSGDSE ETTTPETITQ TVTPTETTTS EEPTLAPPPV QPTRQPVPTP DETPTRLPTT 430 440 450 460 470 480 TQESPTRVSP TPEETDEPGE QTTPGGQPPL STLPTSLGWQ NNQGGTGNQG NPNTTGNPAN 490 500 510 520 PGTPGTTGGN GTGNAGGNSP DAADELLMSL DELMNVGGNQ

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000035 Genomic DNA. Translation: BAC16844.1.
RefSeq	NP_736644.1. NC_004369.1.
3D structure databases
ProteinModelPortal	Q8FUI4.
ModBase	Search...
Protein-protein interaction databases
STRING	196164.CE0034.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC16844; BAC16844; BAC16844.
GeneID	1032163.
KEGG	cef:CE0034.
PATRIC	21486253. VBICorEff9312_0082.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000037187.
KO	K08884.
OMA	LQWIVGH.
ProtClustDB	CLSK632623.
Enzyme and pathway databases
BioCyc	CEFF196164:GJW8-36-MONOMER.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKN2_COREF

Accession

Primary (citable) accession number: Q8FUI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program