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Q8FTL6

- NADK_COREF

UniProt

Q8FTL6 - NADK_COREF

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Protein

NAD kinase

Gene

nadK

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Proton acceptorUniRule annotation
Binding sitei85 – 851NADUniRule annotation
Binding sitei185 – 1851NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812NADUniRule annotation
Nucleotide bindingi155 – 1562NADUniRule annotation
Nucleotide bindingi196 – 2016NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:CE1547
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318NAD kinasePRO_0000229627Add
BLAST

Proteomic databases

PRIDEiQ8FTL6.

Interactioni

Protein-protein interaction databases

STRINGi196164.CE1547.

Structurei

3D structure databases

ProteinModelPortaliQ8FTL6.
SMRiQ8FTL6. Positions 6-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FTL6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTETTERIVL LVPHTGRSSN IESAVLAAEH LDRAGITVRV LVNEEDDPIK
60 70 80 90 100
THPVLGRFEH VIHSRTAAEG AELVLVLGGD GTFLRAADLA HAVDLPVLGI
110 120 130 140 150
NLGHVGFLAE WESDSLEDAV KRVIDCDYRV EDRMTLDVIV RDSDLEVIGR
160 170 180 190 200
GWALNEVSVE NLNRRGVLDA TLEVDFRPVA SFGCDGVLIS TPTGSTAYAF
210 220 230 240 250
SAGGPVLWPE LDAILVVPNN AHALFTKPLV VSPRSTVAVE SMSGTSPAMA
260 270 280 290 300
VMDGFRPIPM PPGSRVEIVR GKRPVRWVRL DSLPFTDRLV HKLRLPVVGW
310
RGPDKQKELL DAETPDQP
Length:318
Mass (Da):34,627
Last modified:March 1, 2003 - v1
Checksum:iB942247EF8F451FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC18357.1.
RefSeqiNP_738157.1. NC_004369.1.

Genome annotation databases

EnsemblBacteriaiBAC18357; BAC18357; BAC18357.
GeneIDi1034018.
KEGGicef:CE1547.
PATRICi21489225. VBICorEff9312_1536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC18357.1 .
RefSeqi NP_738157.1. NC_004369.1.

3D structure databases

ProteinModelPortali Q8FTL6.
SMRi Q8FTL6. Positions 6-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE1547.

Proteomic databases

PRIDEi Q8FTL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18357 ; BAC18357 ; BAC18357 .
GeneIDi 1034018.
KEGGi cef:CE1547.
PATRICi 21489225. VBICorEff9312_1536.

Phylogenomic databases

HOGENOMi HOG000227223.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiNADK_COREF
AccessioniPrimary (citable) accession number: Q8FTL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3