Q8FTL6 (PPNK_COREF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	CE1547

Organism

Corynebacterium efficiens [Complete proteome] [HAMAP]

Taxonomic identifier

152794 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000229627

Sequences

	Sequence		Length	Mass (Da)
	Q8FTL6 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: B942247EF8F451FF	FASTA	318	34,627
	10 20 30 40 50 60 MTETTERIVL LVPHTGRSSN IESAVLAAEH LDRAGITVRV LVNEEDDPIK THPVLGRFEH 70 80 90 100 110 120 VIHSRTAAEG AELVLVLGGD GTFLRAADLA HAVDLPVLGI NLGHVGFLAE WESDSLEDAV 130 140 150 160 170 180 KRVIDCDYRV EDRMTLDVIV RDSDLEVIGR GWALNEVSVE NLNRRGVLDA TLEVDFRPVA 190 200 210 220 230 240 SFGCDGVLIS TPTGSTAYAF SAGGPVLWPE LDAILVVPNN AHALFTKPLV VSPRSTVAVE 250 260 270 280 290 300 SMSGTSPAMA VMDGFRPIPM PPGSRVEIVR GKRPVRWVRL DSLPFTDRLV HKLRLPVVGW 310 RGPDKQKELL DAETPDQP

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000035 Genomic DNA. Translation: BAC18357.1.
RefSeq	NP_738157.1. NC_004369.1.
3D structure databases
ProteinModelPortal	Q8FTL6.
SMR	Q8FTL6. Positions 6-302.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1034018.
GenomeReviews	Gene locus CE1547 in contig BA000035_GR.
KEGG	cef:CE1547.
NMPDR	fig|196164.1.peg.1547.
PATRIC	21489225. VBICorEff9312_1536.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
OMA	GPVVWPE.
PhylomeDB	Q8FTL6.
ProtClustDB	PRK03372.
Enzyme and pathway databases
BioCyc	CEFF196164:CE1547-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_COREF

Accession

Primary (citable) accession number: Q8FTL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program