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Q8FTL6

- NADK_COREF

UniProt

Q8FTL6 - NADK_COREF

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Protein
NAD kinase
Gene
nadK, CE1547
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei80 – 801Proton acceptor By similarity
Binding sitei85 – 851NAD By similarity
Binding sitei185 – 1851NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi80 – 812NAD By similarity
Nucleotide bindingi155 – 1562NAD By similarity
Nucleotide bindingi196 – 2016NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:CE1547
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318NAD kinaseUniRule annotation
PRO_0000229627Add
BLAST

Proteomic databases

PRIDEiQ8FTL6.

Interactioni

Protein-protein interaction databases

STRINGi196164.CE1547.

Structurei

3D structure databases

ProteinModelPortaliQ8FTL6.
SMRiQ8FTL6. Positions 6-302.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FTL6-1 [UniParc]FASTAAdd to Basket

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MTETTERIVL LVPHTGRSSN IESAVLAAEH LDRAGITVRV LVNEEDDPIK    50
THPVLGRFEH VIHSRTAAEG AELVLVLGGD GTFLRAADLA HAVDLPVLGI 100
NLGHVGFLAE WESDSLEDAV KRVIDCDYRV EDRMTLDVIV RDSDLEVIGR 150
GWALNEVSVE NLNRRGVLDA TLEVDFRPVA SFGCDGVLIS TPTGSTAYAF 200
SAGGPVLWPE LDAILVVPNN AHALFTKPLV VSPRSTVAVE SMSGTSPAMA 250
VMDGFRPIPM PPGSRVEIVR GKRPVRWVRL DSLPFTDRLV HKLRLPVVGW 300
RGPDKQKELL DAETPDQP 318
Length:318
Mass (Da):34,627
Last modified:March 1, 2003 - v1
Checksum:iB942247EF8F451FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18357.1.
RefSeqiNP_738157.1. NC_004369.1.

Genome annotation databases

EnsemblBacteriaiBAC18357; BAC18357; BAC18357.
GeneIDi1034018.
KEGGicef:CE1547.
PATRICi21489225. VBICorEff9312_1536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18357.1 .
RefSeqi NP_738157.1. NC_004369.1.

3D structure databases

ProteinModelPortali Q8FTL6.
SMRi Q8FTL6. Positions 6-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE1547.

Proteomic databases

PRIDEi Q8FTL6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18357 ; BAC18357 ; BAC18357 .
GeneIDi 1034018.
KEGGi cef:CE1547.
PATRICi 21489225. VBICorEff9312_1536.

Phylogenomic databases

HOGENOMi HOG000227223.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiNADK_COREF
AccessioniPrimary (citable) accession number: Q8FTL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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