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Q8FTH7 (THIM_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:CE1592
OrganismCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]
Taxonomic identifier196164 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156931

Sites

Binding site441Substrate; via amide nitrogen By similarity
Binding site1191ATP By similarity
Binding site1651ATP By similarity
Binding site1921Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FTH7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D1B8F3924D9C03D2

FASTA27027,414
        10         20         30         40         50         60 
MADSYLHAPT LVRATTPLVQ CLTNAVVMQF TANALLAIGA SPAMVDTPAE SFDFAGVADG 

        70         80         90        100        110        120 
VLINAGTPSA EQYAGMERAI EGATAAGTPW VLDPVGVGGL AERSAFLRRA VDKHPAAIRG 

       130        140        150        160        170        180 
NASEIVALAG LGAGGRGVDA TDDVADAVEA AQVLARRTGG VVAVTGAEDL IVSRGRVSWL 

       190        200        210        220        230        240 
KSGDPMLQLV IGTGCALGAV TAAYLGATQD TDIDPHDAVV AAHAHLGAAG RIAATRATAP 

       250        260        270 
GSYAVALIDA LHQLDRNQLA NLTHLREENR 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC18402.1.
RefSeqNP_738202.1. NC_004369.1.

3D structure databases

ProteinModelPortalQ8FTH7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE1592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC18402; BAC18402; BAC18402.
GeneID1034065.
KEGGcef:CE1592.
PATRIC21489323. VBICorEff9312_1584.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000114352.
KOK00878.
OMANACTQLA.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycCEFF196164:GJW8-1619-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_COREF
AccessionPrimary (citable) accession number: Q8FTH7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways