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Q8FTC9 (UPPP_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:CE1640
OrganismCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]
Taxonomic identifier196164 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence caution

The sequence BAC18450.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151139

Regions

Transmembrane107 – 12721Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane268 – 28821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8FTC9 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: B5E9D18D3A285BFD

FASTA29331,845
        10         20         30         40         50         60 
MNEQTYLLAS AVEPVAAENM SWTQTLVLSV VQGLTEFLPI SSSGHLRIIS ELFWGADAGA 

        70         80         90        100        110        120 
SFTAVVQLGT EAAVLVYFAR EIWQILTGWF AGVFNKDRRG RDYKMGWMII VATIPVVVLG 

       130        140        150        160        170        180 
VLGKDLIRDA LRNMWITATV LVLFSFVFIL AEKVGKKDRG YDELNMRDAL VMGFAQCLAL 

       190        200        210        220        230        240 
IPGVSRSGGT ISAGLFMGLN REVAAKFSFL LAIPAVLGSG LYSLPDAFDP STGQAASGLQ 

       250        260        270        280        290 
LTIGTLVAFL VGYASIAWLM KFVANHSFSW FAAYRIPAGL LVMLLLWLGY LNP 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC18450.1. Different initiation.
RefSeqNP_738250.2. NC_004369.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE1640.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC18450; BAC18450; BAC18450.
GeneID1032009.
KEGGcef:CE1640.
PATRIC21489421. VBICorEff9312_1633.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000218357.
KOK06153.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCEFF196164:GJW8-1667-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_COREF
AccessionPrimary (citable) accession number: Q8FTC9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families