Q8FTA8 (ACON_COREF) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 71.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Aconitate hydratase EC=4.2.1.3 | ||||
| Gene names |
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| Organism | Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 196164 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › ![]() |
Protein attributes
| Sequence length | 937 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the isomerization of citrate to isocitrate via cis-aconitate By similarity. |
| Catalytic activity | Citrate = isocitrate. |
| Cofactor | Binds 1 4Fe-4S cluster per subunit By similarity. |
| Pathway | Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2. |
| Induction | Repressed by AcnR By similarity. |
| Sequence similarities | Belongs to the aconitase/IPM isomerase family. |
| Sequence caution | The sequence BAC18471.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Ligand | Iron Iron-sulfur Metal-binding |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway |
| Molecular_function | citrate hydro-lyase (cis-aconitate-forming) activity Inferred from electronic annotation. Source: EC iron-sulfur cluster bindingInferred from electronic annotation. Source: UniProtKB-KW isocitrate hydro-lyase (cis-aconitate-forming) activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000035 Genomic DNA. Translation: BAC18471.1. Different initiation. |
| RefSeq | NP_738271.1. NC_004369.1. |
3D structure databases | |
| ProteinModelPortal | Q8FTA8. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 196164.CE1661. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | BAC18471; BAC18471; BAC18471. |
| GeneID | 1032014. |
| KEGG | cef:CE1661. |
| PATRIC | 21489469. VBICorEff9312_1655. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HOG000025704. |
| KO | K01681. |
| ProtClustDB | PRK09277. |
Enzyme and pathway databases | |
| UniPathway | UPA00223; UER00718. |
Family and domain databases | |
| Gene3D | 3.20.19.10. 1 hit. 3.30.499.10. 3 hits. 3.40.1060.10. 1 hit. |
| InterPro | IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3. IPR015937. Acoase/IPM_deHydtase. IPR001030. Acoase/IPM_deHydtase_lsu_aba. IPR015928. Aconitase/3IPM_dehydase_swvl. IPR015934. Aconitase/Fe_reg_prot_2/AcnD. IPR015932. Aconitase/IPMdHydase_lsu_aba_2. IPR018136. Aconitase_4Fe-4S_BS. IPR000573. AconitaseA/IPMdHydase_ssu_swvl. [Graphical view] |
| PANTHER | PTHR11670. PTHR11670. 1 hit. PTHR11670:SF1. PTHR11670:SF1. 1 hit. |
| Pfam | PF00330. Aconitase. 2 hits. PF00694. Aconitase_C. 1 hit. [Graphical view] |
| PRINTS | PR00415. ACONITASE. |
| SUPFAM | SSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit. SSF53732. Aconitase_N. 1 hit. |
| PROSITE | PS00450. ACONITASE_1. 1 hit. PS01244. ACONITASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ACON_COREF | ||||||||
| Accession | Primary (citable) accession number: Q8FTA8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
