Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q8FTA8 (ACON_COREF)

Last modified March 3, 2009. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aconitate hydratase
    EC=4.2.1.3
Gene names
Name: acn
Ordered Locus Names: CE1661
OrganismCorynebacterium efficiens [Complete proteome] [HAMAP]
Taxonomic identifier152794 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length937 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Citrate = isocitrate.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle.

Induction

Repressed by acnR By similarity.

Sequence similarities

Belongs to the aconitase/IPM isomerase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandIron
Iron-sulfur
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function4 iron, 4 sulfur cluster binding

Inferred from electronic annotation. Source: InterPro

aconitate hydratase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 937937Aconitate hydratase
PRO_0000076659

Sites

Metal binding4751Iron-sulfur (4Fe-4S) By similarity
Metal binding5411Iron-sulfur (4Fe-4S) By similarity
Metal binding5441Iron-sulfur (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FTA8-1 [UniParc].

Last modified February 7, 2006. Version 2.
Checksum: D23E4FD27C675273

FASTA937102,106
        10         20         30         40         50         60 
MTESKNSFNA KSTLQVGEKS YDYYALSAVP GMEKLPYSLK VLGENLLRTE DGANITEEHI 

        70         80         90        100        110        120 
EAIANWDASA DPSIEIQFTP ARVLMQDFTG VPCVVDLATM REAVKTLGGD PDKVNPLNPA 

       130        140        150        160        170        180 
EMVIDHSVIV EAFGRPDALE KNVEIEYERN EERYQFLRWG SEAFSNFRVV PPGTGIVHQV 

       190        200        210        220        230        240 
NIEYLARVVF DNDGLAYPDT CIGTDSHTTM ENGLGILGWG VGGIEAEAAM LGQPVSMLIP 

       250        260        270        280        290        300 
RVVGFKLTGE IPVGVTATDV VLTITEMLRD HGVVQKFVEF YGNGVKSVPL ANRATIGNMS 

       310        320        330        340        350        360 
PEFGSTCAMF PIDEETIKYL RLTGRPEEQI ALVEAYAKAQ GMWLEQDAPE AEYSEYLELD 

       370        380        390        400        410        420 
LSTVVPSIAG PKRPQDRILL SEAKEQFRED LKAYTNDPVQ VDQSIPAKRM ANEGGFQPGS 

       430        440        450        460        470        480 
TSDLDNYNAS WPGEGESAAA NAEGRPSNPV TVVSPQGGEY TIDHGMVAIA SITSCTNTSN 

       490        500        510        520        530        540 
PSVMIGAGLI ARKAAEKGLK SKPWVKTICA PGSQVVDGYY QRADLWKDLE ALGFYLSGFG 

       550        560        570        580        590        600 
CTTCIGNSGP LPEEISEAIN EHDLAATAVL SGNRNFEGRI SPDVKMNYLA SPIMVIAYAI 

       610        620        630        640        650        660 
AGTMDFDFEN EALGQDQDGN DVFLKDIWPS TEEIEETIQA AISRELYEAD YADVFKGDKQ 

       670        680        690        700        710        720 
WQELDIPSGK TFEWDENSTY IRKAPYFDGM TAEPQPVTDI ENARVLAKLG DSVTTDHISP 

       730        740        750        760        770        780 
ASSIKPGTPA AQYLDAHGVE RQDYNSLGSR RGNHEVMMRG TFANIRLQNQ LVDIAGGYTR 

       790        800        810        820        830        840 
DFTQEGGPQA FIYDACVNYK EAGIPLVVLA GKEYGTGSSR DWAAKGTNLL GVRAVITESF 

       850        860        870        880        890        900 
ERIHRSNLIG MGVVPLQFPE GESHESLGLD GTETFDITGL TALNEGTTPK TVKVTATKEN 

       910        920        930 
GEKVEFDAVV RIDTPGEADY FRHGGILQYV LRQMAAS 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

BA000035 Genomic DNA. Translation: BAC18471.1. Different initiation.
RefSeqNP_738271.1.

3D structure databases

HSSPHSSP built from PDB template 7ACN based on UniProtKB P16276.
ModBaseSearch...

Genome annotation databases

GeneID1032014.
GenomeReviewsGene locus CE1661 in contig BA000035_GR.
KEGGcef:CE1661.
NMPDRfig|196164.1.peg.1661.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8FTA8.

Enzyme and pathway databases

BioCycCEFF196164:CE1661-MON.
BRENDA4.2.1.3. 277326.

Family and domain databases

InterProIPR015931. Acnase/IPM_dHydase_lsu_aba_1/3.
IPR001030. Acoase/IPM_deHydtase_lsu_aba.
IPR015937. Aconitase-like_core.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR006249. Aconitase/Fe_reg_prot_2.
IPR015934. Aconitase/Fe_reg_prot_2/AcnD.
IPR015932. Aconitase/IPMdHydase_lsu_aba_2.
IPR018136. Aconitase_4Fe-4S_BS.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
Gene3DG3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 2 hits.
G3DSA:3.20.19.10. Aconitase/3IPM_dehydase_swvl. 1 hit.
G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
PANTHERPTHR11670. Aconitase-like_core. 1 hit.
PTHR11670:SF1. Aconitase/Fe_reg_prot_2/AcnD. 1 hit.
PfamPF00330. Aconitase. 1 hit.
PF00694. Aconitase_C. 1 hit.
[Graphical view]
PRINTSPR00415. ACONITASE.
ProDomPD000511. Aconitase_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01341. aconitase_1. 1 hit.
PROSITEPS00450. ACONITASE_1. 1 hit.
PS01244. ACONITASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACON_COREF
AccessionPrimary (citable) accession number: Q8FTA8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: March 3, 2009
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents