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Q8FT74

- Q8FT74_COREF

UniProt

Q8FT74 - Q8FT74_COREF

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf, HMPREF0290_1731
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691NADP By similarityUniRule annotation
Binding sitei176 – 1761NADP By similarityUniRule annotation
Binding sitei206 – 2061Substrate By similarityUniRule annotation
Binding sitei210 – 2101Substrate By similarityUniRule annotation
Binding sitei244 – 2441Substrate By similarityUniRule annotation
Binding sitei263 – 2631Substrate By similarityUniRule annotation
Active sitei268 – 2681Proton acceptor By similarityUniRule annotation
Binding sitei366 – 3661Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotationImported
ORF Names:HMPREF0290_1731Imported
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)Imported
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi196164.CE1696.

Structurei

3D structure databases

ProteinModelPortaliQ8FT74.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FT74-1 [UniParc]FASTAAdd to Basket

« Hide

MSSHTNPTTW INPLRDPQDK RLPRIAGPSG LVIFGVTGDL ARKKLLPAIY    50
DLANRGLLPP GFALVGYGRR DWSKEDFENY VREAVEAGAR TEFRGNVWER 100
LAEGMEFVKG NFDDDSAFDN LADTLKRLDE TRGTAGNWAF YLSIPPDSFA 150
AVCHQLERSG MAASTDESWR RVIIEKPFGN DLKTAHELNE TVNAVFPEES 200
VFRIDHYLGK ETVQNILALR FANQLFEPLW NSNYVDHVQI TMAEDIGLGG 250
RAGYYDGIGA ARDVIQNHLI QLLALVAMEE PISFTPTQLQ AEKIKVLRAT 300
KPSLPIAENS ARGQYSAGWQ GSEYVKGLRE EDGFDPESTT ETYAACTLEI 350
TSRRWAGVPF YLRTGKRLGR RVTEIAVVFK DAPHQPFDPG MTAALGNNAI 400
VIRVQPDEGV LIRFGSKVPG SAMEVRDVNM DFSYSESFTE ESPEAYERLI 450
LDALLDESSL FPTNEEVELS WKILDPILEI WEENGQPEEY PAGTWGPKSA 500
DEMLARNGHQ WRRP 514
Length:514
Mass (Da):57,621
Last modified:March 1, 2003 - v1
Checksum:i27CFBFDD591C42B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18506.1.
ACLI01000086 Genomic DNA. Translation: EEW49669.1.
RefSeqiNP_738306.1. NC_004369.1.

Genome annotation databases

EnsemblBacteriaiBAC18506; BAC18506; BAC18506.
EEW49669; EEW49669; HMPREF0290_1731.
GeneIDi1034193.
KEGGicef:CE1696.
PATRICi21489533. VBICorEff9312_1687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18506.1 .
ACLI01000086 Genomic DNA. Translation: EEW49669.1 .
RefSeqi NP_738306.1. NC_004369.1.

3D structure databases

ProteinModelPortali Q8FT74.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE1696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18506 ; BAC18506 ; BAC18506 .
EEW49669 ; EEW49669 ; HMPREF0290_1731 .
GeneIDi 1034193.
KEGGi cef:CE1696.
PATRICi 21489533. VBICorEff9312_1687.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395 and YS-314Imported.
  2. Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L., Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V., Kovar C., Mata R., Mathew T., Ngo R.
    , Nguyen L., Nguyen N., Okwuonu G., Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A., Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C., Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S., Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S., Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L., Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P., Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K., Petrosino J., Highlander S., Gibbs R.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: YS-314Imported.

Entry informationi

Entry nameiQ8FT74_COREF
AccessioniPrimary (citable) accession number: Q8FT74
Secondary accession number(s): C8NP06
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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