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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69NADPUniRule annotation1
Binding sitei176NADPUniRule annotation1
Binding sitei206SubstrateUniRule annotation1
Binding sitei210SubstrateUniRule annotation1
Binding sitei244SubstrateUniRule annotation1
Binding sitei263SubstrateUniRule annotation1
Active sitei268Proton acceptorUniRule annotation1
Binding sitei366SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotation

Keywords - Ligandi

NADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)Imported
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1731.

Structurei

3D structure databases

ProteinModelPortaliQ8FT74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 215G6PD_NInterPro annotationAdd BLAST184
Domaini217 – 512G6PD_CInterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
HOGENOMiHOG000046191.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiPOG091H04ZM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FT74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSHTNPTTW INPLRDPQDK RLPRIAGPSG LVIFGVTGDL ARKKLLPAIY
60 70 80 90 100
DLANRGLLPP GFALVGYGRR DWSKEDFENY VREAVEAGAR TEFRGNVWER
110 120 130 140 150
LAEGMEFVKG NFDDDSAFDN LADTLKRLDE TRGTAGNWAF YLSIPPDSFA
160 170 180 190 200
AVCHQLERSG MAASTDESWR RVIIEKPFGN DLKTAHELNE TVNAVFPEES
210 220 230 240 250
VFRIDHYLGK ETVQNILALR FANQLFEPLW NSNYVDHVQI TMAEDIGLGG
260 270 280 290 300
RAGYYDGIGA ARDVIQNHLI QLLALVAMEE PISFTPTQLQ AEKIKVLRAT
310 320 330 340 350
KPSLPIAENS ARGQYSAGWQ GSEYVKGLRE EDGFDPESTT ETYAACTLEI
360 370 380 390 400
TSRRWAGVPF YLRTGKRLGR RVTEIAVVFK DAPHQPFDPG MTAALGNNAI
410 420 430 440 450
VIRVQPDEGV LIRFGSKVPG SAMEVRDVNM DFSYSESFTE ESPEAYERLI
460 470 480 490 500
LDALLDESSL FPTNEEVELS WKILDPILEI WEENGQPEEY PAGTWGPKSA
510
DEMLARNGHQ WRRP
Length:514
Mass (Da):57,621
Last modified:March 1, 2003 - v1
Checksum:i27CFBFDD591C42B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC18506.1.
RefSeqiWP_006767697.1. NZ_GG700683.1.

Genome annotation databases

EnsemblBacteriaiBAC18506; BAC18506; BAC18506.
KEGGicef:CE1696.
PATRICi21489533. VBICorEff9312_1687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC18506.1.
RefSeqiWP_006767697.1. NZ_GG700683.1.

3D structure databases

ProteinModelPortaliQ8FT74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1731.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC18506; BAC18506; BAC18506.
KEGGicef:CE1696.
PATRICi21489533. VBICorEff9312_1687.

Phylogenomic databases

eggNOGiENOG4105D8W. Bacteria.
COG0364. LUCA.
HOGENOMiHOG000046191.
KOiK00036.
OMAiTIFEPIW.
OrthoDBiPOG091H04ZM.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8FT74_COREF
AccessioniPrimary (citable) accession number: Q8FT74
Secondary accession number(s): C8NP06
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.