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Q8FT66 (PGK_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:CE1705
OrganismCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]
Taxonomic identifier196164 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145936

Regions

Nucleotide binding361 – 3644ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1221Substrate By similarity
Binding site1621Substrate By similarity
Binding site2121ATP By similarity
Binding site3311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FT66 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 5AC048AFBAA0B575

FASTA40543,078
        10         20         30         40         50         60 
MAVKTLKDLL DEGVDGRHVI VRSDFNVPLN DDREITDKGR IIASLPTLKA LTEAGAKVIV 

        70         80         90        100        110        120 
MSHLGRPKGE VNEKYSLAPV AEALSDELGQ YVALAADVVG EDAHERANGL TEGDILLLEN 

       130        140        150        160        170        180 
VRFDPRETSK DEAERGAFAD ELAALAADNG AFVSDGFGVV HRAQTSVYDI AKRLPHYAGR 

       190        200        210        220        230        240 
LVENEISVLE KIAENPEAPY TVVLGGSKVS DKLGVIEALA SKADSIIIGG GMCYTFLKAQ 

       250        260        270        280        290        300 
GHDVQKSMLQ DEMIDTCKDL LERFGDKIVL PVDLTWASEF AKDAEKKVTD LDSAPEGWLS 

       310        320        330        340        350        360 
LDIGPKSVEK FADVLGASKT IFWNGPMGVF EFEAFSDGTR GVAQAIIDAT ANNGAFSVVG 

       370        380        390        400 
GGDSAASVRV LGLDEEGFSH ISTGGGASLE FLEGKELPGV AILKD 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC18515.1.
RefSeqNP_738315.1. NC_004369.1.

3D structure databases

ProteinModelPortalQ8FT66.
SMRQ8FT66. Positions 4-405.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE1705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC18515; BAC18515; BAC18515.
GeneID1032016.
KEGGcef:CE1705.
PATRIC21489551. VBICorEff9312_1696.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000227107.
KOK00927.
OMAHASVYDI.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_COREF
AccessionPrimary (citable) accession number: Q8FT66
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways