Reviewed, UniProtKB/Swiss-Prot Q8FT45 (KGUA_COREF)

Names and origin

Protein names

Recommended name:
    Guanylate kinase
    EC=2.7.4.8
Alternative name(s):
    GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	CE1726

Organism

Corynebacterium efficiens [Complete proteome] [HAMAP]

Taxonomic identifier

152794 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity.
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP guanylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Guanylate kinase HAMAP MF_00328		PRO_0000170528
Regions
	Domain	8 – 188	181	Guanylate kinase-like
	Nucleotide binding	15 – 22	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FT45-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 7C6869ADB2802F73	FASTA	190	20,975
	10 20 30 40 50 60 MSGDKPHGRL VILAGPSAVG KSTVVDRLRS DVPNLYFSVS MTTRDPRPGE VDGRDYFYVT 70 80 90 100 110 120 AQEFQEKIDR GEMLEWADIH GGLQRSGTPA EPVRQAREEG RPVLVEVDLV GARNIARLIP 130 140 150 160 170 180 EAETIFLAPP SWEVLVERLT GRGTESQDVI NRRLETAREE LAAQSEFKHV IINDDVDTAV 190 SAIKAVLLGT

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000035 Genomic DNA. Translation: BAC18536.1.
RefSeq	NP_738336.1.
3D structure databases
HSSP	HSSP built from PDB template 1LVG based on UniProtKB Q64520.
ModBase	Search...
Genome annotation databases
GeneID	1034222.
GenomeReviews	Gene locus CE1726 in contig BA000035_GR.
KEGG	cef:CE1726.
NMPDR	fig|196164.1.peg.1726.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8FT45.
OMA	EWAEFAG.
Enzyme and pathway databases
BioCyc	CEFF196164:CE1726-MON.
BRENDA	2.7.4.8. 277326.
Family and domain databases
HAMAP	MF_00328. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. IPR008145. Guanylt/Ca. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_COREF

Accession

Primary (citable) accession number: Q8FT45

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)