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Q8FT43

- PYRF_COREF

UniProt

Q8FT43 - PYRF_COREF

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, CE1728
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:CE1728
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_0000134624Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196164.CE1728.

Structurei

3D structure databases

ProteinModelPortaliQ8FT43.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000245748.
KOiK01591.
OMAiHIHARHP.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FT43-1 [UniParc]FASTAAdd to Basket

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MTQTFGENLL DAASTRGRLC VGIDPHESLL RAWGLPVDAT GLAEFSRICV    50
EAFADTVALV KPQVAFYERF GSRGFAVLEE TIGTLRERGC LVVSDAKRGD 100
IGSTMAGYAT AWLDPGSPLS SDAVTVSPYL GFGSLQPVFD LAEEHGRGVF 150
VLAATSNPEA RVLQDQTDAS GVSISQQIVN EAAALNAPHL AQHRAGNIGV 200
VVGATLTDPP ALSGLNGAIL MPGVGTQGGT AQDVGTIAGD MAHLAFPNVS 250
RAVLAQGPDV GNLRVAVSET AAEFPGFPRS 280
Length:280
Mass (Da):28,927
Last modified:March 1, 2003 - v1
Checksum:i815854B480C73D32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18538.1.
RefSeqiNP_738338.1. NC_004369.1.
WP_006767728.1. NZ_GG700683.1.

Genome annotation databases

EnsemblBacteriaiBAC18538; BAC18538; BAC18538.
GeneIDi1034227.
KEGGicef:CE1728.
PATRICi21489595. VBICorEff9312_1718.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18538.1 .
RefSeqi NP_738338.1. NC_004369.1.
WP_006767728.1. NZ_GG700683.1.

3D structure databases

ProteinModelPortali Q8FT43.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE1728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18538 ; BAC18538 ; BAC18538 .
GeneIDi 1034227.
KEGGi cef:CE1728.
PATRICi 21489595. VBICorEff9312_1718.

Phylogenomic databases

HOGENOMi HOG000245748.
KOi K01591.
OMAi HIHARHP.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiPYRF_COREF
AccessioniPrimary (citable) accession number: Q8FT43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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