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Q8FT43 (PYRF_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:CE1728
OrganismCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]
Taxonomic identifier196164 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_0000134624

Sites

Active site971Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FT43 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 815854B480C73D32

FASTA28028,927
        10         20         30         40         50         60 
MTQTFGENLL DAASTRGRLC VGIDPHESLL RAWGLPVDAT GLAEFSRICV EAFADTVALV 

        70         80         90        100        110        120 
KPQVAFYERF GSRGFAVLEE TIGTLRERGC LVVSDAKRGD IGSTMAGYAT AWLDPGSPLS 

       130        140        150        160        170        180 
SDAVTVSPYL GFGSLQPVFD LAEEHGRGVF VLAATSNPEA RVLQDQTDAS GVSISQQIVN 

       190        200        210        220        230        240 
EAAALNAPHL AQHRAGNIGV VVGATLTDPP ALSGLNGAIL MPGVGTQGGT AQDVGTIAGD 

       250        260        270        280 
MAHLAFPNVS RAVLAQGPDV GNLRVAVSET AAEFPGFPRS 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC18538.1.
RefSeqNP_738338.1. NC_004369.1.

3D structure databases

ProteinModelPortalQ8FT43.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE1728.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC18538; BAC18538; BAC18538.
GeneID1034227.
KEGGcef:CE1728.
PATRIC21489595. VBICorEff9312_1718.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000245748.
KOK01591.
OMAHIHARHP.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_COREF
AccessionPrimary (citable) accession number: Q8FT43
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways