Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91D-inositol 3-phosphateUniRule annotation1
Binding sitei23UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei781D-inositol 3-phosphateUniRule annotation1
Binding sitei1101D-inositol 3-phosphateUniRule annotation1
Binding sitei1341D-inositol 3-phosphateUniRule annotation1
Binding sitei1541D-inositol 3-phosphateUniRule annotation1
Binding sitei231UDP-GlcNAcUniRule annotation1
Binding sitei236UDP-GlcNAcUniRule annotation1
Binding sitei294UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi303Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi304Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi306Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei316UDP-GlcNAcUniRule annotation1
Binding sitei324UDP-GlcNAcUniRule annotation1
Metal bindingi330MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Protein family/group databases

CAZyiGT4 Glycosyltransferase Family 4

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:CE0422
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001171 – 424D-inositol 3-phosphate glycosyltransferaseAdd BLAST424

Proteomic databases

PRIDEiQ8FSH1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196164.HMPREF0290_2959

Structurei

3D structure databases

ProteinModelPortaliQ8FSH1
SMRiQ8FSH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 16UDP-GlcNAc bindingUniRule annotation2
Regioni20 – 251D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M Bacteria
COG0438 LUCA
HOGENOMiHOG000077288
KOiK15521
OMAiHTMAKVK
OrthoDBiPOG091H0AO3

Family and domain databases

HAMAPiMF_01695 MshA, 1 hit
InterProiView protein in InterPro
IPR001296 Glyco_trans_1
IPR028098 Glyco_trans_4-like_N
IPR017814 Mycothiol_biosynthesis_MshA
PfamiView protein in Pfam
PF13439 Glyco_transf_4, 1 hit
PF00534 Glycos_transf_1, 1 hit
TIGRFAMsiTIGR03449 mycothiol_MshA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FSH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAMISMHT SPLQQPGVGD SGGMNVYILS TGTELARQGV EVDIFTRATR
60 70 80 90 100
PSQGEVVQVA PNLRVINIVA GPYEGLAKEE LSTQLAAFAG GVLEFTRRGG
110 120 130 140 150
IEYDLIHSHY WLSGQVGWLM RDLWRIPLVH TAHTLAAVKN SYRADEDTPE
160 170 180 190 200
SEARRICEQQ LVDNADVLAV NTQEELADLV HHYDADPDRI SVVSPGADIA
210 220 230 240 250
LYTPGNDRAT ERSRRELGVP LHAKVVAFVG RLQPFKGPQV LIHAVAELLE
260 270 280 290 300
RDPQRNLRVL ICGGPSGPSA TPETYRNLAV ELGVDKRIRF LDPRPPEELV
310 320 330 340 350
AVYRAADIIA VPSYNESFGL VAMEAQATGT PVVAARVGGL PVAVAEGETG
360 370 380 390 400
LLVDGHDPAL WADTLATLLD DDETRIRMGQ DAVEHARNFS WAATATQLSS
410 420
LYSEATTAEC DGGIPRRADG ARWD
Length:424
Mass (Da):46,017
Last modified:March 1, 2003 - v1
Checksum:iBAE1EDBDC024E26A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA Translation: BAC17232.1
RefSeqiWP_006770340.1, NZ_GG700690.1

Genome annotation databases

EnsemblBacteriaiBAC17232; BAC17232; BAC17232
KEGGicef:CE0422

Similar proteinsi

Entry informationi

Entry nameiMSHA_COREF
AccessioniPrimary (citable) accession number: Q8FSH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health