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Reviewed, UniProtKB/Swiss-Prot Q8FSF0 (AROE_COREF)

Last modified November 3, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Quinate/shikimate dehydrogenase
    EC=1.1.1.24
    EC=1.1.1.-
Alternative name(s):
    NAD(+)-dependent quinate dehydrogenase
      Short name=QDH
Gene names
Name: aroE
Ordered Locus Names: CE0443
OrganismCorynebacterium efficiens [Complete proteome] [HAMAP]
Taxonomic identifier152794 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD+-dependent oxidation of both quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate, respectively. Seems to play a key role in the quinate degradation pathway By similarity.

Catalytic activity

Quinate + NAD+ = 3-dehydroquinate + NADH. HAMAP MF_00222

Shikimate + NAD+ = 3-dehydroshikimate + NADH. HAMAP MF_00222

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 284284Quinate/shikimate dehydrogenase HAMAP MF_00222
PRO_0000325114

Regions

Nucleotide binding135 – 1395NAD By similarity
Nucleotide binding252 – 2565NAD By similarity

Sites

Active site741Proton acceptor Potential
Binding site1111Substrate By similarity
Binding site1591NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FSF0-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7179FA02CF0DE537

FASTA28429,938
        10         20         30         40         50         60 
MNHDSILLGL IGEDISLSRT PAMHEAEGLA QGAATVYRRI DTLTDRARGR SLQELLDAAR 

        70         80         90        100        110        120 
STGFNGLNIT HPYKQAVLPL LDEVSEQAAQ LGAVNTVVIG EDGRTSGHNT DVTGFARGLE 

       130        140        150        160        170        180 
EGLPDATMTT VVQVGAGGVG NAVAYSLVTH GVEQLQVADL DPARAQALAD AINSAIGREA 

       190        200        210        220        230        240 
VHGIDARGVE EAIAAADGVV NATPMGMLAH PGTAFDTSCL TPHHWVGDVV YMPIETQLLK 

       250        260        270        280 
DARALGCRTL DGTRMAIHQA VDAFRLFTGL EPDVERMRAT FLSL 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

BA000035 Genomic DNA. Translation: BAC17253.1.
RefSeqNP_737053.1.

3D structure databases

HSSPHSSP built from PDB template 1NVT based on UniProtKB Q58484.
SMRQ8FSF0. Positions 4-284.
ModBaseSearch...

Genome annotation databases

GeneID1034899.
GenomeReviewsGene locus CE0443 in contig BA000035_GR.
KEGGcef:CE0443.
NMPDRfig|196164.1.peg.443.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8FSF0.
OMAVKAFELF.

Enzyme and pathway databases

BioCycCEFF196164:CE0443-MON.
BRENDA1.1.1.25. 277326.

Family and domain databases

HAMAPMF_00222. Divergent sequence.
[Tree]
InterProIPR016040. NAD(P)-bd_dom.
IPR005097. Saccharopine_DH.
IPR013708. Shikimate_DH-bd_N.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF03435. Saccharop_dh. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROE_COREF
AccessionPrimary (citable) accession number: Q8FSF0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents