Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei147L-tryptophanUniRule annotation1
Binding sitei198ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 23ATPUniRule annotation3
Nucleotide bindingi30 – 31ATPUniRule annotation2
Nucleotide bindingi159 – 161ATPUniRule annotation3
Nucleotide bindingi207 – 211ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:CE0696
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366251 – 346Tryptophan--tRNA ligaseAdd BLAST346

Proteomic databases

PRIDEiQ8FRR3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1033

Structurei

3D structure databases

ProteinModelPortaliQ8FRR3
SMRiQ8FRR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 31"HIGH" regionUniRule annotation10
Motifi207 – 211"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FRR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSQDNDHTA QTPARVLSGI QPTADSYHLG NYLGAVKQWI DLQNSYDAFY
60 70 80 90 100
FIPDLHAITV DQNPEELRAR TVSGAAQLLA LGIDPERSTL FVQSHIPAHA
110 120 130 140 150
ELSWVLTCLT GFGEASRMTQ FKDKSTKQGA ERTSAGLFTY PMLMAADILL
160 170 180 190 200
YRPQLVPVGE DQRQHLELTR TLAERFNNRF GTVFEVPEGF IPEGASKIYD
210 220 230 240 250
LQNPTAKMSK SGENPKGLIN LLDDPKVSSK RIKSAVTDND GVIAFDVANK
260 270 280 290 300
PGVSNLLVIQ SALTGESVDK LVAGYEGKGY GALKTDTADA LEAFTTPLRA
310 320 330 340
KYDEYMSDRA ELERVLAIGA ERAGEIATKV LAEVYDKIGF LAPRSR
Length:346
Mass (Da):37,888
Last modified:March 1, 2003 - v1
Checksum:i872FE798B2848DA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA Translation: BAC17506.1
RefSeqiWP_006769625.1, NZ_GG700687.1

Genome annotation databases

EnsemblBacteriaiBAC17506; BAC17506; BAC17506
KEGGicef:CE0696

Similar proteinsi

Entry informationi

Entry nameiSYW_COREF
AccessioniPrimary (citable) accession number: Q8FRR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health