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Q8FR39 (G6PI_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CE0927
OrganismCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]
Taxonomic identifier196164 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180632

Sites

Active site3531Proton donor By similarity
Active site3841 By similarity
Active site5081 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FR39 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 802521D17B11A4BA

FASTA54259,230
        10         20         30         40         50         60 
MANDITTTAA WQSLTERYEA FQGTTLRELF QDGGRAEKLS FDAAGLRVDL SKNLLDDAIL 

        70         80         90        100        110        120 
TDLVALAEQA GLTDRIEAMF RGEHINNTED RAVLHTALRL PVEESLEVDG QDVAADVHEV 

       130        140        150        160        170        180 
LGRMRDFATA LRSGAWLGYT GRTIKKVVNI GIGGSDLGPA MATKALRAYA TAGITAEFVS 

       190        200        210        220        230        240 
NVDPADMVSV LEDLDAESTL FVIASKTFTT QETLANANAA KNWLIEQLGS EEAVSKHFVA 

       250        260        270        280        290        300 
VSTNAEKVTA FGINPENMFG FWDWVGGRYS VDSAVGLSLM AVIGPRDFMR FLGGFRAMDE 

       310        320        330        340        350        360 
HFRYTDFGQN VPVLMALLSV WYTDFFGAET HAVLPYSEDL SRFAAYLQQL TMESNGKSVR 

       370        380        390        400        410        420 
RDGSPVTTGT GEIYWGEPGT NGQHAFFQLI HQGTRLIPAD FIGFARPKQD LPAGEKSMHD 

       430        440        450        460        470        480 
LLMSNFFAQT KVLAFGKTAE EIAAEGVDDN LINHKVMPGN RPTTTILAEE LTPAVLGALI 

       490        500        510        520        530        540 
ALYEHIVFVQ GVIWDINSFD QWGVELGKQQ ASDLAPAVSG EVEVDSGDSS TDALIRWYRT 


NR 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC17737.1.
RefSeqNP_737537.1. NC_004369.1.

3D structure databases

ProteinModelPortalQ8FR39.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE0927.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC17737; BAC17737; BAC17737.
GeneID1033035.
KEGGcef:CE0927.
PATRIC21487994. VBICorEff9312_0933.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000261370.
KOK01810.
OMAMIALTHY.
OrthoDBEOG64R61J.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_COREF
AccessionPrimary (citable) accession number: Q8FR39
Entry history
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways