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Protein

Isoprenyl transferase 1

Gene

uppS1

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341UniRule annotation
Metal bindingi34 – 341MagnesiumUniRule annotation
Binding sitei39 – 391SubstrateUniRule annotation
Binding sitei52 – 521SubstrateUniRule annotation
Active sitei83 – 831Proton acceptorUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei205 – 2051SubstrateUniRule annotation
Metal bindingi224 – 2241MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-1074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferase 1UniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppS1UniRule annotation
Ordered Locus Names:CE1055
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Isoprenyl transferase 1PRO_0000123603Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1407.

Structurei

3D structure databases

ProteinModelPortaliQ8FQR4.
SMRiQ8FQR4. Positions 26-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni35 – 384Substrate bindingUniRule annotation
Regioni80 – 823Substrate bindingUniRule annotation
Regioni211 – 2133Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK12503.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FQR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNLPRLLYP LYERRLLKEL NGARQPGHVA IMCDGNRRWA REAGFVDLSH
60 70 80 90 100
GHRVGAKKIG ELVRWCDDVD VDLVTVYLLS TENLGRDEAE LQLLYDIIGD
110 120 130 140 150
VVAELSLPET NCRVRLVGHL DLLPKEFAER LRGTVCETVD HTGVAVNIAV
160 170 180 190 200
GYGGRQEIVD AVRDLLTSAR DEGKTLDEVI ESVDAQAIST HLYTSGQPDP
210 220 230 240 250
DLVIRTSGEQ RLSGFMLWQS AYSEIWFTDT YWPAFRRIDF LRALRDYSQR

SRRFGK
Length:256
Mass (Da):29,090
Last modified:February 16, 2004 - v2
Checksum:i4AE6994D4049125F
GO

Sequence cautioni

The sequence BAC17865.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC17865.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiBAC17865; BAC17865; BAC17865.
KEGGicef:CE1055.
PATRICi21488246. VBICorEff9312_1057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC17865.1. Different initiation.

3D structure databases

ProteinModelPortaliQ8FQR4.
SMRiQ8FQR4. Positions 26-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC17865; BAC17865; BAC17865.
KEGGicef:CE1055.
PATRICi21488246. VBICorEff9312_1057.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK12503.
OrthoDBiEOG68H89T.

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-1074-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiISPT1_COREF
AccessioniPrimary (citable) accession number: Q8FQR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: December 9, 2015
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.