Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isoprenyl transferase 1

Gene

uppS1

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei34UniRule annotation1
Metal bindingi34MagnesiumUniRule annotation1
Binding sitei39SubstrateUniRule annotation1
Binding sitei52SubstrateUniRule annotation1
Active sitei83Proton acceptorUniRule annotation1
Binding sitei86SubstrateUniRule annotation1
Binding sitei205SubstrateUniRule annotation1
Metal bindingi224MagnesiumUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferase 1UniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppS1UniRule annotation
Ordered Locus Names:CE1055
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001236031 – 256Isoprenyl transferase 1Add BLAST256

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1407.

Structurei

3D structure databases

ProteinModelPortaliQ8FQR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 38Substrate bindingUniRule annotation4
Regioni80 – 82Substrate bindingUniRule annotation3
Regioni211 – 213Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK12503.
OrthoDBiPOG091H00BZ.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FQR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNLPRLLYP LYERRLLKEL NGARQPGHVA IMCDGNRRWA REAGFVDLSH
60 70 80 90 100
GHRVGAKKIG ELVRWCDDVD VDLVTVYLLS TENLGRDEAE LQLLYDIIGD
110 120 130 140 150
VVAELSLPET NCRVRLVGHL DLLPKEFAER LRGTVCETVD HTGVAVNIAV
160 170 180 190 200
GYGGRQEIVD AVRDLLTSAR DEGKTLDEVI ESVDAQAIST HLYTSGQPDP
210 220 230 240 250
DLVIRTSGEQ RLSGFMLWQS AYSEIWFTDT YWPAFRRIDF LRALRDYSQR

SRRFGK
Length:256
Mass (Da):29,090
Last modified:February 16, 2004 - v2
Checksum:i4AE6994D4049125F
GO

Sequence cautioni

The sequence BAC17865 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC17865.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiBAC17865; BAC17865; BAC17865.
KEGGicef:CE1055.
PATRICi21488246. VBICorEff9312_1057.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC17865.1. Different initiation.

3D structure databases

ProteinModelPortaliQ8FQR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC17865; BAC17865; BAC17865.
KEGGicef:CE1055.
PATRICi21488246. VBICorEff9312_1057.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006056.
KOiK12503.
OrthoDBiPOG091H00BZ.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISPT1_COREF
AccessioniPrimary (citable) accession number: Q8FQR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.