Q8FQR2 (COAA_COREF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	CE1057

Organism

Corynebacterium efficiens [Complete proteome] [HAMAP]

Taxonomic identifier

152794 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Pantothenate kinase HAMAP MF_00215		PRO_0000194423
Regions
	Nucleotide binding	113 – 120	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8FQR2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E6737A57964DC2C5	FASTA	328	37,255
	10 20 30 40 50 60 MAAPLNAQTR APQATGRAPD FSPYLDFDRA QWRELRKSMP QVLTEEEVVA LRGLGENIDL 70 80 90 100 110 120 DEVAEVYLPL SRLIHLQVNA RQELTVATET FLGTSSARMF PGSHVPFVIG VAGSVAVGKS 130 140 150 160 170 180 TTARLLQVLL QRWSSHPRVD LVTTDGFLYP GEELQRRGIM NRKGFPESYD QRALLRFVTD 190 200 210 220 230 240 VKSGKFNVRA PVYSHTAYDR VPGKYITVDQ PDILIVEGLN VLQTGPTLMV SDLFDFSVYV 250 260 270 280 290 300 DARTEDIERW YIERFLQLRD TAFRHPDAHF RHYADIGDEK ATAVAREIWQ SINLPNLVEN 310 320 ILPTRVRASL VLRKSADHLV ERVRMRKL

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000035 Genomic DNA. Translation: BAC17867.1.
RefSeq	NP_737667.1. NC_004369.1.
3D structure databases
ProteinModelPortal	Q8FQR2.
SMR	Q8FQR2. Positions 22-328.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1033229.
GenomeReviews	Gene locus CE1057 in contig BA000035_GR.
KEGG	cef:CE1057.
NMPDR	fig|196164.1.peg.1057.
PATRIC	21488250. VBICorEff9312_1059.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q8FQR2.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	CEFF196164:CE1057-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_COREF

Accession

Primary (citable) accession number: Q8FQR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program