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Q8FQ57 (SYR_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:CE1276
OrganismCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]
Taxonomic identifier196164 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151553

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q8FQ57 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EE355FD485AC4DA5

FASTA55059,900
        10         20         30         40         50         60 
MTPADLATLI KQTAVEVLTS RDLDASMLPE QIVVERPRNP EHGDYATNVA LQVAKKVGVT 

        70         80         90        100        110        120 
PRDLGTWLAE ALAADDSIDS AEIAGPGFIN IRLAAAAQGE IVAKILEQGE KFGTSDHLSH 

       130        140        150        160        170        180 
LDVNLEFVSA NPTGPIHLGG TRWAAVGDSL GRVLEAAGAK VTREYYFNDH GRQIDRFALS 

       190        200        210        220        230        240 
LLAAAKGEPT PEDGYGGEYI REIAEAIVAK HPDALDRTPE ETQELFRSEG VEMMFSHIRE 

       250        260        270        280        290        300 
SLHEFGTDFD VYFHENSLFE SGAVDRAVQK LKDNGNLYES DGAWWLRSTD FGDDKDRVVI 

       310        320        330        340        350        360 
KSDGDAAYIA GDIAYVQDKF ERGHNLNIYM LGADHHGYIA RLKAAAAALG YAPEGVEVLI 

       370        380        390        400        410        420 
GQMVNLLRDG TAVRMSKRAG TVVTLDDLVE AIGIDAARYS LIRSSVDSSL DIDLGLWESQ 

       430        440        450        460        470        480 
SSDNPVYYVQ YGHARLCSIA RKAADLGVTY EDADLSLLTH DREGDLIRTL GEFPAVIRAA 

       490        500        510        520        530        540 
ADLREPHRIA RYAEELAGTF HRFYDSCQIL PKADEEKAPI HAARLALAAA TRQTLANALA 

       550 
LVGVSAPEKM 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC18086.1.
RefSeqNP_737886.1. NC_004369.1.

3D structure databases

ProteinModelPortalQ8FQ57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE1276.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC18086; BAC18086; BAC18086.
GeneID1033514.
KEGGcef:CE1276.
PATRIC21488686. VBICorEff9312_1276.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000247214.
KOK01887.
OMAQQEVFRS.
OrthoDBEOG6JB13C.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_COREF
AccessionPrimary (citable) accession number: Q8FQ57
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries