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Protein

Uridylate kinase

Gene

pyrH

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of UMP to UDP.UniRule annotation

Catalytic activityi

ATP + UMP = ADP + UDP.UniRule annotation

Enzyme regulationi

Inhibited by UTP.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UDP from UMP (UMPK route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uridylate kinase (pyrH)
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP from UMP (UMPK route), the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59UMP; via amide nitrogenUniRule annotation1
Binding sitei60ATP; via amide nitrogenUniRule annotation1
Binding sitei64ATPUniRule annotation1
Binding sitei79UMPUniRule annotation1
Binding sitei173ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei176ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 21ATPUniRule annotation4
Nucleotide bindingi140 – 147UMPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00275

Names & Taxonomyi

Protein namesi
Recommended name:
Uridylate kinaseUniRule annotation (EC:2.7.4.22UniRule annotation)
Short name:
UKUniRule annotation
Alternative name(s):
Uridine monophosphate kinaseUniRule annotation
Short name:
UMP kinaseUniRule annotation
Short name:
UMPKUniRule annotation
Gene namesi
Name:pyrHUniRule annotation
Ordered Locus Names:CE1911
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000539191 – 243Uridylate kinaseAdd BLAST243

Proteomic databases

PRIDEiQ8FP74

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1947

Structurei

3D structure databases

ProteinModelPortaliQ8FP74
SMRiQ8FP74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UMP kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0528 LUCA
HOGENOMiHOG000047187
KOiK09903
OMAiPIIVFDM
OrthoDBiPOG091H02JZ

Family and domain databases

Gene3Di3.40.1160.10, 1 hit
HAMAPiMF_01220_B PyrH_B, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR011817 Uridylate_kinase
IPR015963 Uridylate_kinase_bac
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PIRSFiPIRSF005650 Uridylate_kin, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
TIGRFAMsiTIGR02075 pyrH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FP74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSSIEPRN SYKRVMLKLG GEMFGGGKVG IDPDVVDNVA RQIAEVAKSG
60 70 80 90 100
AEIAVVIGGG NFFRGAELQQ RGMDRARSDY MGMLGTVMNC LALQDFLGQH
110 120 130 140 150
GVECRVQTAI NMAQVAEPYL PLRAERHLEK GRVVIFGAGM GMPYFSTDTT
160 170 180 190 200
AAQRALEIGC DVLLMAKAVD GVYSADPRTN PDAELFTEIT PKEVIEKSLK
210 220 230 240
VADATAFSLC MDNNMPILVF NLLTDGNIAR AVNGERIGTL VQS
Length:243
Mass (Da):26,181
Last modified:March 1, 2003 - v1
Checksum:i0875027D2B1A73AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA Translation: BAC18721.1

Genome annotation databases

EnsemblBacteriaiBAC18721; BAC18721; BAC18721
KEGGicef:CE1911

Similar proteinsi

Entry informationi

Entry nameiPYRH_COREF
AccessioniPrimary (citable) accession number: Q8FP74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health