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Protein

Ribonuclease HII

Gene

rnhB

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Divalent metal cationUniRule annotation1
Metal bindingi30Divalent metal cationUniRule annotation1
Metal bindingi123Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:CE1925
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001115681 – 231Ribonuclease HIIAdd BLAST231

Proteomic databases

PRIDEiQ8FP63

Interactioni

Protein-protein interaction databases

STRINGi196164.HMPREF0290_1958

Structurei

3D structure databases

ProteinModelPortaliQ8FP63
SMRiQ8FP63
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UH2 Bacteria
COG0164 LUCA
HOGENOMiHOG000100288
KOiK03470
OMAiNILHASM
OrthoDBiPOG091H011N

Family and domain databases

CDDicd07182 RNase_HII_bacteria_HII_like, 1 hit
Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00052_B RNase_HII_B, 1 hit
InterProiView protein in InterPro
IPR022898 RNase_HII
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PTHR10954:SF18 PTHR10954:SF18, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequencei

Sequence statusi: Complete.

Q8FP63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIRRLKQL RTYEVALSRH GLGPVAGVDE AGRGACCGPI SIAACILPDR
60 70 80 90 100
PIADLAVLTD SKQLSPPVRA RLMPLVKKHA VAWSVIHISA ADIDRFGIQH
110 120 130 140 150
ANISGMRRAV AALEVRPGYV LTDAFRIPGL PCPSLPIPGG DASARCIAAA
160 170 180 190 200
SVLAKQTRDE IMTDMAQQFP QYGLAGHKGY STKVHMDAVR RHGASPQHRY
210 220 230
SYANVAKAHR EWALSHSDTE VQNTGKVEHE R
Length:231
Mass (Da):24,991
Last modified:March 1, 2003 - v1
Checksum:iF723F97E087BB788
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA Translation: BAC18735.1
RefSeqiWP_006767924.1, NZ_GG700683.1

Genome annotation databases

EnsemblBacteriaiBAC18735; BAC18735; BAC18735
KEGGicef:CE1925

Similar proteinsi

Entry informationi

Entry nameiRNH2_COREF
AccessioniPrimary (citable) accession number: Q8FP63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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