Q8FNS7 (Q8FNS7_COREF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Ordered Locus Names:

CE2066

Organism

Corynebacterium efficiens [Complete proteome] [HAMAP]

Taxonomic identifier

152794 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	369 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8FNS7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DED1F88B0606DC8B	FASTA	369	40,540
	10 20 30 40 50 60 MVMCCAQRES FPKIVVAAVA GAGGMKTGAR SLPDHLHNIR YPGMSSTNIS ASSQWSISEV 70 80 90 100 110 120 LKRPVPGRVP FSVEFMPPRD DAAENRLYRA AEVFHDLGAS FVSVTYGAGG STRERTARVA 130 140 150 160 170 180 RRLSRQPLTT LVHLTLVDHT IAELQEILRG YAELGLTNLL ALRGDPPGDP LGEWATSEGG 190 200 210 220 230 240 MSYALELIEM IKNSPEFSHF DIGIASFPEG HYRAGSLEND TRYTLAKLRA GAEYSITQMF 250 260 270 280 290 300 FDVEDFLRLR DRLVAADPIH GAKPIIPGLM PITSLRSVRR QVELSGSTLP RALEEKLLRA 310 320 330 340 350 360 ANGDEEANRN EIRKVGIETT SEMAERLIAE GVPDLHFMTL NFTRATQEVL HNLGMAPAWG AEHGHDAVR

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000035 Genomic DNA. Translation: BAC18876.1.
RefSeq	NP_738676.1. NC_004369.1.
3D structure databases
HSSP	HSSP built from PDB template 1B5T based on UniProtKB P00394.
ProteinModelPortal	Q8FNS7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1034801.
GenomeReviews	Gene locus CE2066 in contig BA000035_GR.
KEGG	cef:CE2066.
NMPDR	fig|196164.1.peg.2066.
PATRIC	21490267. VBICorEff9312_2048.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
PhylomeDB	Q8FNS7.
ProtClustDB	CLSK638719.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8FNS7_COREF

Accession

Primary (citable) accession number: Q8FNS7

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)