Q8FNQ9 (COX3_COREF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III

Gene names

Name:	ctaE
Ordered Locus Names:	CE2085

Organism

Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]

Taxonomic identifier

196164 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium › Corynebacterium efficiens

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Associates with subunits I, II and IV to form cytochrome c oxidase By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.
Sequence caution	The sequence BAC18895.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Cytochrome c oxidase subunit 3		PRO_0000183879
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	73 – 93	21	Helical; Potential
	Transmembrane	104 – 124	21	Helical; Potential
	Transmembrane	144 – 164	21	Helical; Potential
	Transmembrane	184 – 204	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8FNQ9 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: F6CF257E68E2BA85	FASTA	205	22,419
	10 20 30 40 50 60 MTSAVGNTGM AAPQRVAALN RPNMVSVGTI VFLSQELMFF AGLFAMYFVS RANGLANGSW 70 80 90 100 110 120 AEQTDYLNVP YALAITVILV SSSVTCQFGV FAAERGDVYG LRKWFLITII LGSIFVIGQA 130 140 150 160 170 180 YEYFTLVGHG LSIQSSVYGS AFYITTGFHA AHVIAGVIAF VVVLMRIQKA KFTPAQATAA 190 200 MVVSYYWHFV DVVWIGLFIT IYFIQ

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000035 Genomic DNA. Translation: BAC18895.1. Different initiation.
RefSeq	NP_738695.1. NC_004369.1.
3D structure databases
ProteinModelPortal	Q8FNQ9.
ModBase	Search...
Protein-protein interaction databases
STRING	196164.CE2085.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC18895; BAC18895; BAC18895.
GeneID	1034871.
KEGG	cef:CE2085.
PATRIC	21490305. VBICorEff9312_2067.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000086399.
KO	K02276.
ProtClustDB	CLSK2519647.
Enzyme and pathway databases
BioCyc	CEFF196164:GJW8-2121-MONOMER.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_COREF

Accession

Primary (citable) accession number: Q8FNQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program