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Q8FNQ7

- COX2_COREF

UniProt

Q8FNQ7 - COX2_COREF

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Protein
Cytochrome c oxidase subunit 2
Gene
ctaC, CE2087
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 2 copper A ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi244 – 2441Copper A1 By similarity
Metal bindingi285 – 2851Copper A1 By similarity
Metal bindingi285 – 2851Copper A2 By similarity
Metal bindingi287 – 2871Copper A2; via carbonyl oxygen By similarity
Metal bindingi289 – 2891Copper A1 By similarity
Metal bindingi289 – 2891Copper A2 By similarity
Metal bindingi293 – 2931Copper A2 By similarity
Metal bindingi296 – 2961Copper A1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-2123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:CE2087
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421Helical; Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 By similarity
Add
BLAST
Chaini29 – 359331Cytochrome c oxidase subunit 2 By similarity
PRO_0000006053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi29 – 291N-palmitoyl cysteine By similarity
Lipidationi29 – 291S-diacylglycerol cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Associates with subunits I, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi196164.CE2087.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000245527.
KOiK02275.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8FNQ7-1 [UniParc]FASTAAdd to Basket

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MEQQNKRGLK RKALLGGVLG SGGLAMAGCE VSPPGGMIGD FLRMGWPSGI    50
TPEAVSMGNF WSWVWVAAWI IGIIMWGLML TAIFSWNAKK AEKRGEGEFP 100
KQLQYNVPLE LVLTIVPIII VMVLFFFTVQ TQDRVTALDK NPEVTVNVTA 150
YQWNWKFGYG ELAPEFAPAG GDYDGVDEAR QASAEASKID PSGNNPIHGN 200
SKKDMSYLHF NQIETLGTTD EVPVLVLPTN TPIEFNLASA DVAHSFWVPE 250
FLFKRDLYAH PEANKSQRVF QIDEIFEEGA FVGRCAEMCG TYHAMMNFEL 300
RTVDRETFAE YIAFRDANPD ATNAQALEHI GEAPYATSTA PFVSDRTGTR 350
DGENFQTPA 359
Length:359
Mass (Da):39,765
Last modified:April 26, 2005 - v2
Checksum:iB5CB70825F161436
GO

Sequence cautioni

The sequence BAC18897.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18897.1. Different initiation.
RefSeqiNP_738697.1. NC_004369.1.

Genome annotation databases

EnsemblBacteriaiBAC18897; BAC18897; BAC18897.
GeneIDi1031940.
KEGGicef:CE2087.
PATRICi21490309. VBICorEff9312_2069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18897.1 . Different initiation.
RefSeqi NP_738697.1. NC_004369.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 196164.CE2087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18897 ; BAC18897 ; BAC18897 .
GeneIDi 1031940.
KEGGi cef:CE2087.
PATRICi 21490309. VBICorEff9312_2069.

Phylogenomic databases

HOGENOMi HOG000245527.
KOi K02275.
OrthoDBi EOG68SVXT.

Enzyme and pathway databases

BioCyci CEFF196164:GJW8-2123-MONOMER.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiCOX2_COREF
AccessioniPrimary (citable) accession number: Q8FNQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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