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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

binuclear copper center (CuA)By similarityNote: Binds a binuclear copper A center per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi244Copper A1By similarity1
Metal bindingi285Copper A1By similarity1
Metal bindingi285Copper A2By similarity1
Metal bindingi287Copper A2; via carbonyl oxygenBy similarity1
Metal bindingi289Copper A1By similarity1
Metal bindingi289Copper A2By similarity1
Metal bindingi293Copper A2By similarity1
Metal bindingi296Copper A1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:CE2087
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28PROSITE-ProRule annotationAdd BLAST28
ChainiPRO_000000605329 – 359Cytochrome c oxidase subunit 2PROSITE-ProRule annotationAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi29N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi29S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Associates with subunits I, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi196164.HMPREF0290_2123.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000245527.
KOiK02275.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8FNQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQQNKRGLK RKALLGGVLG SGGLAMAGCE VSPPGGMIGD FLRMGWPSGI
60 70 80 90 100
TPEAVSMGNF WSWVWVAAWI IGIIMWGLML TAIFSWNAKK AEKRGEGEFP
110 120 130 140 150
KQLQYNVPLE LVLTIVPIII VMVLFFFTVQ TQDRVTALDK NPEVTVNVTA
160 170 180 190 200
YQWNWKFGYG ELAPEFAPAG GDYDGVDEAR QASAEASKID PSGNNPIHGN
210 220 230 240 250
SKKDMSYLHF NQIETLGTTD EVPVLVLPTN TPIEFNLASA DVAHSFWVPE
260 270 280 290 300
FLFKRDLYAH PEANKSQRVF QIDEIFEEGA FVGRCAEMCG TYHAMMNFEL
310 320 330 340 350
RTVDRETFAE YIAFRDANPD ATNAQALEHI GEAPYATSTA PFVSDRTGTR

DGENFQTPA
Length:359
Mass (Da):39,765
Last modified:April 26, 2005 - v2
Checksum:iB5CB70825F161436
GO

Sequence cautioni

The sequence BAC18897 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC18897.1. Different initiation.
RefSeqiWP_035108852.1. NZ_GG700683.1.

Genome annotation databases

EnsemblBacteriaiBAC18897; BAC18897; BAC18897.
KEGGicef:CE2087.
PATRICi21490309. VBICorEff9312_2069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC18897.1. Different initiation.
RefSeqiWP_035108852.1. NZ_GG700683.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196164.HMPREF0290_2123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC18897; BAC18897; BAC18897.
KEGGicef:CE2087.
PATRICi21490309. VBICorEff9312_2069.

Phylogenomic databases

eggNOGiENOG4105CV4. Bacteria.
COG1622. LUCA.
HOGENOMiHOG000245527.
KOiK02275.
OrthoDBiPOG091H05L4.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_COREF
AccessioniPrimary (citable) accession number: Q8FNQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.