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Q8FNQ7

- COX2_COREF

UniProt

Q8FNQ7 - COX2_COREF

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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 2 copper A ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi244 – 2441Copper A1By similarity
Metal bindingi285 – 2851Copper A1By similarity
Metal bindingi285 – 2851Copper A2By similarity
Metal bindingi287 – 2871Copper A2; via carbonyl oxygenBy similarity
Metal bindingi289 – 2891Copper A1By similarity
Metal bindingi289 – 2891Copper A2By similarity
Metal bindingi293 – 2931Copper A2By similarity
Metal bindingi296 – 2961Copper A1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-2123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:CE2087
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Cell membrane PROSITE-ProRule annotation; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828PROSITE-ProRule annotationAdd
BLAST
Chaini29 – 359331Cytochrome c oxidase subunit 2PROSITE-ProRule annotationPRO_0000006053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi29 – 291N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi29 – 291S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Associates with subunits I, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi196164.CE2087.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000245527.
KOiK02275.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8FNQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQQNKRGLK RKALLGGVLG SGGLAMAGCE VSPPGGMIGD FLRMGWPSGI
60 70 80 90 100
TPEAVSMGNF WSWVWVAAWI IGIIMWGLML TAIFSWNAKK AEKRGEGEFP
110 120 130 140 150
KQLQYNVPLE LVLTIVPIII VMVLFFFTVQ TQDRVTALDK NPEVTVNVTA
160 170 180 190 200
YQWNWKFGYG ELAPEFAPAG GDYDGVDEAR QASAEASKID PSGNNPIHGN
210 220 230 240 250
SKKDMSYLHF NQIETLGTTD EVPVLVLPTN TPIEFNLASA DVAHSFWVPE
260 270 280 290 300
FLFKRDLYAH PEANKSQRVF QIDEIFEEGA FVGRCAEMCG TYHAMMNFEL
310 320 330 340 350
RTVDRETFAE YIAFRDANPD ATNAQALEHI GEAPYATSTA PFVSDRTGTR

DGENFQTPA
Length:359
Mass (Da):39,765
Last modified:April 26, 2005 - v2
Checksum:iB5CB70825F161436
GO

Sequence cautioni

The sequence BAC18897.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18897.1. Different initiation.
RefSeqiNP_738697.1. NC_004369.1.

Genome annotation databases

EnsemblBacteriaiBAC18897; BAC18897; BAC18897.
GeneIDi1031940.
KEGGicef:CE2087.
PATRICi21490309. VBICorEff9312_2069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18897.1 . Different initiation.
RefSeqi NP_738697.1. NC_004369.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE2087.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18897 ; BAC18897 ; BAC18897 .
GeneIDi 1031940.
KEGGi cef:CE2087.
PATRICi 21490309. VBICorEff9312_2069.

Phylogenomic databases

HOGENOMi HOG000245527.
KOi K02275.
OrthoDBi EOG68SVXT.

Enzyme and pathway databases

BioCyci CEFF196164:GJW8-2123-MONOMER.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiCOX2_COREF
AccessioniPrimary (citable) accession number: Q8FNQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3