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Q8FNH2

- GLMS_COREF

UniProt

Q8FNH2 - GLMS_COREF

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei618 – 6181For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CE2172
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 623622Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135326Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi196164.CE2172.

Structurei

3D structure databases

ProteinModelPortaliQ8FNH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 228227Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini295 – 435141SIS 1UniRule annotationAdd
BLAST
Domaini468 – 613146SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8FNH2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYIGQ AGDTRNYYAL DVVLEGLRRL EYRGYDSAGV AVYADGEISF
60 70 80 90 100
RKKAGKVAAL ETEIARAPLP DSVLGIGHTR WATHGGPTDV NAHPHVVAGG
110 120 130 140 150
RLAVVHNGII ENFSELRAEL TAKGYNFVSS TDTEVAATLL AEIYKTEAEG
160 170 180 190 200
DLTRAMQLTG QRLDGAFTLL AIHVDHPDRI VAARRNSPLV IGLGEGENFL
210 220 230 240 250
GSDVSGFIDY TRSAVELSND QVVTITADSY EITDFHGAPS EGKPFAVEWD
260 270 280 290 300
AAAAEKGGFH SFMDKEIHDQ PAAVRDTLLG RMDEDGKLML DELRIDESIL
310 320 330 340 350
RSVDKIIVVA CGTAAYAGQV ARYAIEHWCR IPTEVELAHE FRYRDPIVNE
360 370 380 390 400
KTLVVALSQS GETMDTLMAV RHAREQGAKV VAICNTVGST LPREADACLY
410 420 430 440 450
TYAGPEIAVA STKAFLAQIT ASYLLGLYLA QLRGNKFADE VRVILDSLRE
460 470 480 490 500
MPAKIQEVID NEEQIKQLGR SMVDAKSVLF LGRHVGYPVA LEGALKLKEI
510 520 530 540 550
AYLHAEGFAA GELKHGPIAL VEDGQPVFVI VPSPRGRDSL HAKVVSNIQE
560 570 580 590 600
IRARGAVTIV IAEEGDTAVD EHANYIIRIP QAPTLMQPLL ATVPLQIFAC
610 620
AVATEKGFDV DQPRNLAKSV TVE
Length:623
Mass (Da):67,507
Last modified:January 23, 2007 - v3
Checksum:iED4AEB1E50589274
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18982.1.
RefSeqiNP_738782.1. NC_004369.1.
WP_006768175.1. NZ_GG700683.1.

Genome annotation databases

EnsemblBacteriaiBAC18982; BAC18982; BAC18982.
GeneIDi1033138.
KEGGicef:CE2172.
PATRICi21490471. VBICorEff9312_2147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18982.1 .
RefSeqi NP_738782.1. NC_004369.1.
WP_006768175.1. NZ_GG700683.1.

3D structure databases

ProteinModelPortali Q8FNH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE2172.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18982 ; BAC18982 ; BAC18982 .
GeneIDi 1033138.
KEGGi cef:CE2172.
PATRICi 21490471. VBICorEff9312_2147.

Phylogenomic databases

HOGENOMi HOG000258896.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiGLMS_COREF
AccessioniPrimary (citable) accession number: Q8FNH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3