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Q8FNH2

- GLMS_COREF

UniProt

Q8FNH2 - GLMS_COREF

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, CE2172
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei618 – 6181For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:CE2172
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 623622Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135326Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi196164.CE2172.

Structurei

3D structure databases

ProteinModelPortaliQ8FNH2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 228227Glutamine amidotransferase type-2
Add
BLAST
Domaini295 – 435141SIS 1
Add
BLAST
Domaini468 – 613146SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8FNH2-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYIGQ AGDTRNYYAL DVVLEGLRRL EYRGYDSAGV AVYADGEISF    50
RKKAGKVAAL ETEIARAPLP DSVLGIGHTR WATHGGPTDV NAHPHVVAGG 100
RLAVVHNGII ENFSELRAEL TAKGYNFVSS TDTEVAATLL AEIYKTEAEG 150
DLTRAMQLTG QRLDGAFTLL AIHVDHPDRI VAARRNSPLV IGLGEGENFL 200
GSDVSGFIDY TRSAVELSND QVVTITADSY EITDFHGAPS EGKPFAVEWD 250
AAAAEKGGFH SFMDKEIHDQ PAAVRDTLLG RMDEDGKLML DELRIDESIL 300
RSVDKIIVVA CGTAAYAGQV ARYAIEHWCR IPTEVELAHE FRYRDPIVNE 350
KTLVVALSQS GETMDTLMAV RHAREQGAKV VAICNTVGST LPREADACLY 400
TYAGPEIAVA STKAFLAQIT ASYLLGLYLA QLRGNKFADE VRVILDSLRE 450
MPAKIQEVID NEEQIKQLGR SMVDAKSVLF LGRHVGYPVA LEGALKLKEI 500
AYLHAEGFAA GELKHGPIAL VEDGQPVFVI VPSPRGRDSL HAKVVSNIQE 550
IRARGAVTIV IAEEGDTAVD EHANYIIRIP QAPTLMQPLL ATVPLQIFAC 600
AVATEKGFDV DQPRNLAKSV TVE 623
Length:623
Mass (Da):67,507
Last modified:January 23, 2007 - v3
Checksum:iED4AEB1E50589274
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18982.1.
RefSeqiNP_738782.1. NC_004369.1.
WP_006768175.1. NZ_GG700683.1.

Genome annotation databases

EnsemblBacteriaiBAC18982; BAC18982; BAC18982.
GeneIDi1033138.
KEGGicef:CE2172.
PATRICi21490471. VBICorEff9312_2147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC18982.1 .
RefSeqi NP_738782.1. NC_004369.1.
WP_006768175.1. NZ_GG700683.1.

3D structure databases

ProteinModelPortali Q8FNH2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 196164.CE2172.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC18982 ; BAC18982 ; BAC18982 .
GeneIDi 1033138.
KEGGi cef:CE2172.
PATRICi 21490471. VBICorEff9312_2147.

Phylogenomic databases

HOGENOMi HOG000258896.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG6KT2Q1.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiGLMS_COREF
AccessioniPrimary (citable) accession number: Q8FNH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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