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Q8FNH2

- GLMS_COREF

UniProt

Q8FNH2 - GLMS_COREF

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei618 – 6181For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:CE2172
    OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
    Taxonomic identifieri196164 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000001409: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 623622Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135326Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi196164.CE2172.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FNH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 228227Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini295 – 435141SIS 1UniRule annotationAdd
    BLAST
    Domaini468 – 613146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiCRIPCEV.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8FNH2-1 [UniParc]FASTAAdd to Basket

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    MCGIVGYIGQ AGDTRNYYAL DVVLEGLRRL EYRGYDSAGV AVYADGEISF    50
    RKKAGKVAAL ETEIARAPLP DSVLGIGHTR WATHGGPTDV NAHPHVVAGG 100
    RLAVVHNGII ENFSELRAEL TAKGYNFVSS TDTEVAATLL AEIYKTEAEG 150
    DLTRAMQLTG QRLDGAFTLL AIHVDHPDRI VAARRNSPLV IGLGEGENFL 200
    GSDVSGFIDY TRSAVELSND QVVTITADSY EITDFHGAPS EGKPFAVEWD 250
    AAAAEKGGFH SFMDKEIHDQ PAAVRDTLLG RMDEDGKLML DELRIDESIL 300
    RSVDKIIVVA CGTAAYAGQV ARYAIEHWCR IPTEVELAHE FRYRDPIVNE 350
    KTLVVALSQS GETMDTLMAV RHAREQGAKV VAICNTVGST LPREADACLY 400
    TYAGPEIAVA STKAFLAQIT ASYLLGLYLA QLRGNKFADE VRVILDSLRE 450
    MPAKIQEVID NEEQIKQLGR SMVDAKSVLF LGRHVGYPVA LEGALKLKEI 500
    AYLHAEGFAA GELKHGPIAL VEDGQPVFVI VPSPRGRDSL HAKVVSNIQE 550
    IRARGAVTIV IAEEGDTAVD EHANYIIRIP QAPTLMQPLL ATVPLQIFAC 600
    AVATEKGFDV DQPRNLAKSV TVE 623
    Length:623
    Mass (Da):67,507
    Last modified:January 23, 2007 - v3
    Checksum:iED4AEB1E50589274
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000035 Genomic DNA. Translation: BAC18982.1.
    RefSeqiNP_738782.1. NC_004369.1.
    WP_006768175.1. NZ_GG700683.1.

    Genome annotation databases

    EnsemblBacteriaiBAC18982; BAC18982; BAC18982.
    GeneIDi1033138.
    KEGGicef:CE2172.
    PATRICi21490471. VBICorEff9312_2147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000035 Genomic DNA. Translation: BAC18982.1 .
    RefSeqi NP_738782.1. NC_004369.1.
    WP_006768175.1. NZ_GG700683.1.

    3D structure databases

    ProteinModelPortali Q8FNH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196164.CE2172.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC18982 ; BAC18982 ; BAC18982 .
    GeneIDi 1033138.
    KEGGi cef:CE2172.
    PATRICi 21490471. VBICorEff9312_2147.

    Phylogenomic databases

    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi CRIPCEV.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
      Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
      Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

    Entry informationi

    Entry nameiGLMS_COREF
    AccessioniPrimary (citable) accession number: Q8FNH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3