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Q8FMX4

- GLSA_COREF

UniProt

Q8FMX4 - GLSA_COREF

Protein

Glutaminase

Gene

glsA

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei69 – 691SubstrateBy similarity
    Binding sitei119 – 1191SubstrateBy similarity
    Binding sitei165 – 1651SubstrateBy similarity
    Binding sitei172 – 1721SubstrateBy similarity
    Binding sitei196 – 1961SubstrateBy similarity
    Binding sitei248 – 2481SubstrateBy similarity
    Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaminase (EC:3.5.1.2)
    Gene namesi
    Name:glsA
    Ordered Locus Names:CE2375
    OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
    Taxonomic identifieri196164 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000001409: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423GlutaminasePRO_0000110605Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi196164.CE2375.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FMX4.
    SMRiQ8FMX4. Positions 7-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini321 – 423103STASAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni27 – 312286GlutaminaseAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glutaminase family.Curated
    Contains 1 STAS domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiLEHAHRN.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    IPR002645. STAS_dom.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
    PROSITEiPS50801. STAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FMX4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTHPLTMPI PEYFEEILES VRSDVSGEVA QYIPQLKDAD PNPLALAMCT    50
    VDGHIYGAGD DEHEFTMQSV SKPFAYALAL QEQGPEKVFA TVGLEPSGEA 100
    FNELSLDGST NRPMNPMINA GAIAVNQLIN GSESSVEDRV EKIRSYFSAL 150
    AGRELNIDRQ LSETEIEGAD RNLSIAHMLR NYGIIEDDAH DAVLSYTLQC 200
    SVKVTARDLA VMTATLAAGG TQPLTGEKLV DARVARLVLS TMASAGMYDE 250
    AGQWLATVGI PAKSGVSGGL VGVLPGQLGL ATFSPRLNSQ GNPVRGVEIF 300
    KALSEDMGLH LMSAELLTQH AVRAIEERGD TTVIQLQGAM NFSAAENFLF 350
    TVTDHDFTGE KVVLDISRVP MFRPMGRRLV KEGLRRIRDN GFKVAIYDPE 400
    DILPDFDFSD GTKSPQVDDP EEL 423
    Length:423
    Mass (Da):45,863
    Last modified:March 1, 2003 - v1
    Checksum:iCDEB65C617F289CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000035 Genomic DNA. Translation: BAC19185.1.
    RefSeqiNP_738985.1. NC_004369.1.
    WP_006768381.1. NZ_GG700683.1.

    Genome annotation databases

    EnsemblBacteriaiBAC19185; BAC19185; BAC19185.
    GeneIDi1034572.
    KEGGicef:CE2375.
    PATRICi21490879. VBICorEff9312_2345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000035 Genomic DNA. Translation: BAC19185.1 .
    RefSeqi NP_738985.1. NC_004369.1.
    WP_006768381.1. NZ_GG700683.1.

    3D structure databases

    ProteinModelPortali Q8FMX4.
    SMRi Q8FMX4. Positions 7-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196164.CE2375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC19185 ; BAC19185 ; BAC19185 .
    GeneIDi 1034572.
    KEGGi cef:CE2375.
    PATRICi 21490879. VBICorEff9312_2345.

    Phylogenomic databases

    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi LEHAHRN.
    OrthoDBi EOG6N94BK.

    Family and domain databases

    Gene3Di 3.30.750.24. 1 hit.
    3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    IPR002645. STAS_dom.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52091. SSF52091. 1 hit.
    SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    PROSITEi PS50801. STAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
      Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
      Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

    Entry informationi

    Entry nameiGLSA_COREF
    AccessioniPrimary (citable) accession number: Q8FMX4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3