Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8FMX4 (GLSA_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Contains 1 STAS domain.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Glutaminase HAMAP-Rule MF_00313
PRO_0000110605

Regions

Domain321 – 423103STAS
Region27 – 312286Glutaminase HAMAP-Rule MF_00313

Sites

Binding site691Substrate By similarity
Binding site1191Substrate By similarity
Binding site1651Substrate By similarity
Binding site1721Substrate By similarity
Binding site1961Substrate By similarity
Binding site2481Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FMX4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CDEB65C617F289CB

FASTA42345,863
        10         20         30         40         50         60 
MTTHPLTMPI PEYFEEILES VRSDVSGEVA QYIPQLKDAD PNPLALAMCT VDGHIYGAGD 

        70         80         90        100        110        120 
DEHEFTMQSV SKPFAYALAL QEQGPEKVFA TVGLEPSGEA FNELSLDGST NRPMNPMINA 

       130        140        150        160        170        180 
GAIAVNQLIN GSESSVEDRV EKIRSYFSAL AGRELNIDRQ LSETEIEGAD RNLSIAHMLR 

       190        200        210        220        230        240 
NYGIIEDDAH DAVLSYTLQC SVKVTARDLA VMTATLAAGG TQPLTGEKLV DARVARLVLS 

       250        260        270        280        290        300 
TMASAGMYDE AGQWLATVGI PAKSGVSGGL VGVLPGQLGL ATFSPRLNSQ GNPVRGVEIF 

       310        320        330        340        350        360 
KALSEDMGLH LMSAELLTQH AVRAIEERGD TTVIQLQGAM NFSAAENFLF TVTDHDFTGE 

       370        380        390        400        410        420 
KVVLDISRVP MFRPMGRRLV KEGLRRIRDN GFKVAIYDPE DILPDFDFSD GTKSPQVDDP 


EEL 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC19185.1.
RefSeqNP_738985.1. NC_004369.1.

3D structure databases

ProteinModelPortalQ8FMX4.
SMRQ8FMX4. Positions 7-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE2375.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC19185; BAC19185; BAC19185.
GeneID1034572.
KEGGcef:CE2375.
PATRIC21490879. VBICorEff9312_2345.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000216890.
KOK01425.
OMALEHAHRN.
OrthoDBEOG6N94BK.

Family and domain databases

Gene3D3.30.750.24. 1 hit.
3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
IPR002645. STAS_dom.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF52091. SSF52091. 1 hit.
SSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
PROSITEPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLSA_COREF
AccessionPrimary (citable) accession number: Q8FMX4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families