Reviewed, UniProtKB/Swiss-Prot Q8FMU9 (NTPA_COREF)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CE2400

Organism

Corynebacterium efficiens [Complete proteome] [HAMAP]

Taxonomic identifier

152794 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178158

Sequences

	Sequence		Length	Mass (Da)
	Q8FMU9-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: CEFDF6BA87F9F8D5	FASTA	221	23,800
	10 20 30 40 50 60 MNSSMHRRPP WESDMKLLVA SNNAKKLGEL QRILDQAGIE NVELLALADV PSYPEPVEDG 70 80 90 100 110 120 RTFTENALIK ARAGASNTGL ITLADDSGLE VDALNGMPGV LSARWAGKHG NDQANNDLLL 130 140 150 160 170 180 AQIADIPEEH RGAAFVSVCA IVTPDGREFV EEGRWHGTLL REPVGTNGFG YDPLFVPMEE 190 200 210 220 SLIEGRDRSS AQLTAQEKDA LSHRGKALRA LVPAIAELAG Q

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000035 Genomic DNA. Translation: BAC19210.1.
RefSeq	NP_739010.1.
3D structure databases
HSSP	HSSP built from PDB template 1K7K based on UniProtKB P52061.
ModBase	Search...
Genome annotation databases
GeneID	1034567.
GenomeReviews	Gene locus CE2400 in contig BA000035_GR.
KEGG	cef:CE2400.
NMPDR	fig|196164.1.peg.2400.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8FMU9.
OMA	Q8FMU9. VYTADWA.
Enzyme and pathway databases
BioCyc	CEFF196164:CE2400-MON.
BRENDA	3.6.1.15. 277326.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_COREF

Accession

Primary (citable) accession number: Q8FMU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)