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Q8FMT1

- COX1_COREF

UniProt

Q8FMT1 - COX1_COREF

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Protein
Cytochrome c oxidase subunit 1
Gene
ctaD, CE2418
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron (heme A axial ligand) Inferred
Metal bindingi265 – 2651Copper B Inferred
Metal bindingi269 – 2691Copper B Inferred
Metal bindingi314 – 3141Copper B Inferred
Metal bindingi315 – 3151Copper B Inferred
Metal bindingi398 – 3981Iron (heme A3 axial ligand) Inferred
Metal bindingi400 – 4001Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Gene namesi
Name:ctaD
Ordered Locus Names:CE2418
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei259 – 27921Helical; Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Reviewed prediction
Add
BLAST
Transmembranei316 – 33621Helical; Reviewed prediction
Add
BLAST
Transmembranei360 – 38021Helical; Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Reviewed prediction
Add
BLAST
Transmembranei434 – 45421Helical; Reviewed prediction
Add
BLAST
Transmembranei477 – 49721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Cytochrome c oxidase subunit 1
PRO_0000183439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi196164.CE2418.

Structurei

3D structure databases

ProteinModelPortaliQ8FMT1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000085274.
KOiK02274.
OMAiPGIQIFS.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FMT1-1 [UniParc]FASTAAdd to Basket

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MTAVAPRVDG HVAPQRPEPT GHARKGSKAW LMMTTTDHKQ LGIMYIIMSF    50
SFFFLGGLMA LLIRAELFTP GLQFLSNEQF NQLFTMHGTV MLLLYGTPIV 100
WGFANYVLPL QIGAPDVAFP RLNAFGFWIT TVGGVAMLAG FLTPGGAADF 150
GWTMYSPLSD SIHSPGIGSD MWIIGVGATG IGSVASAINM LTTILCLRAP 200
GMTMFRMPVF TWNIFVTSVL ALLIFPLLLA AALGVLYDRK LGGHIYDPAN 250
GGSILWQHLF WFFGHPEVYV LALPFFGIIS EIIPVFSRKP MFGYIGLVFA 300
TLSIGALSMA VWAHHMFVTG AVLLPFFSFM TFLISVPTGV KFFNWVGTMW 350
KGHITWETPM IWAVGFMSTF LFGGLTGIML ASPPLDFHLS DSYFLIAHFH 400
YTLFGTVVFA SCAGVYFWFP KMTGRMMDER LGKIHFWLTF VGFHGTFMVQ 450
HWLGNMGMPR RYADYLDSDG FTTLNQISTI FSFLLGLSVI PFVWNVFKSW 500
RYGELVTVDD PWGYGNSLEW ATSCPPPRHN FTSLPRIRSE RPAFELHYPH 550
MIERMRREAH VGEHDLRAET TQSPTPAEVR 580
Length:580
Mass (Da):64,952
Last modified:March 1, 2003 - v1
Checksum:iE1C111059A367259
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC19228.1.
RefSeqiNP_739028.1. NC_004369.1.
WP_006768424.1. NZ_GG700683.1.

Genome annotation databases

EnsemblBacteriaiBAC19228; BAC19228; BAC19228.
GeneIDi1032090.
KEGGicef:CE2418.
PATRICi21490967. VBICorEff9312_2388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC19228.1 .
RefSeqi NP_739028.1. NC_004369.1.
WP_006768424.1. NZ_GG700683.1.

3D structure databases

ProteinModelPortali Q8FMT1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE2418.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC19228 ; BAC19228 ; BAC19228 .
GeneIDi 1032090.
KEGGi cef:CE2418.
PATRICi 21490967. VBICorEff9312_2388.

Phylogenomic databases

HOGENOMi HOG000085274.
KOi K02274.
OMAi PGIQIFS.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiCOX1_COREF
AccessioniPrimary (citable) accession number: Q8FMT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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