Q8FMR1 (ILVD2_COREF) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 53.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Dihydroxy-acid dehydratase 2 Short name=DAD 2 EC=4.2.1.9 | ||||
| Gene names |
| ||||
| Organism | Corynebacterium efficiens [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 152794 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium |
Protein attributes
| Sequence length | 567 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012 |
| Cofactor | Binds 1 4Fe-4S cluster Potential. |
| Pathway | Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012 |
| Sequence similarities | Belongs to the IlvD/Edd family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Branched-chain amino acid biosynthesis |
| Ligand | 4Fe-4S Iron Iron-sulfur Metal-binding |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW dihydroxy-acid dehydratase activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 567 | 567 | Dihydroxy-acid dehydratase 2 HAMAP MF_00012 | PRO_0000103462 | |||||
Sites | |||||||||
| Metal binding | 129 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
| Metal binding | 206 | 1 | Iron-sulfur (4Fe-4S) Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000035 Genomic DNA. Translation: BAC19249.1. |
| RefSeq | NP_739049.1. NC_004369.1. |
3D structure databases | |
| ProteinModelPortal | Q8FMR1. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1034515. |
| GenomeReviews | Gene locus CE2439 in contig BA000035_GR. |
| KEGG | cef:CE2439. |
| NMPDR | fig|196164.1.peg.2439. |
| PATRIC | 21491013. VBICorEff9312_2409. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG671001. |
| OMA | NMPGAMI. |
| PhylomeDB | Q8FMR1. |
| ProtClustDB | PRK00911. |
Enzyme and pathway databases | |
| BioCyc | CEFF196164:CE2439-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00012. IlvD. [Tree] |
| InterPro | IPR015928. Aconitase/3IPM_dehydase_swvl. IPR004404. DihydroxyA_deHydtase. IPR000581. DiOHA_6PGluconate_deHydtase. IPR020558. DiOHA_6PGluconate_deHydtase_CS. [Graphical view] |
| KO | K01687. |
| PANTHER | PTHR21000. ILVD_EDD_family. 1 hit. |
| Pfam | PF00920. ILVD_EDD. 1 hit. [Graphical view] |
| SUPFAM | SSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit. |
| TIGRFAMs | TIGR00110. IlvD. 1 hit. |
| PROSITE | PS00886. ILVD_EDD_1. 1 hit. PS00887. ILVD_EDD_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ILVD2_COREF | ||||||||
| Accession | Primary (citable) accession number: Q8FMR1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with