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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Desacetylmycothiol; via amide nitrogenUniRule annotation
Binding sitei183 – 1831DesacetylmycothiolUniRule annotation
Binding sitei222 – 2221DesacetylmycothiolUniRule annotation
Binding sitei230 – 2301DesacetylmycothiolUniRule annotation
Binding sitei268 – 2681Desacetylmycothiol; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-2522-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:CE2468
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000001409 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Mycothiol acetyltransferasePRO_0000400249Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi196164.HMPREF0290_0407.

Structurei

3D structure databases

ProteinModelPortaliQ8FMN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 146130N-acetyltransferase 1UniRule annotationAdd
BLAST
Domaini156 – 296141N-acetyltransferase 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni81 – 833Acetyl-CoA binding 1UniRule annotation
Regioni234 – 2363Acetyl-CoA binding 2UniRule annotation
Regioni241 – 2477Acetyl-CoA binding 2UniRule annotation

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF13508. Acetyltransf_7. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FMN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLGPMNTK VTTTHLYNHR DLREQAMIML KEVRAIDGVE ALSEQFVRGL
60 70 80 90 100
AEPGLGHTHY TVSVDGRIIG LGATDGETSE LAVHPAHRRQ GIGRELIDAL
110 120 130 140 150
PTDGVWAHGD LPPAQALASS LGLNKTRELL VMAVEGDALR EAAVYDNPAG
160 170 180 190 200
ITNSSLKTAP GTRDEVEGKW LKANNEAFHW HPEQGGWDRN RLTRAQSATW
210 220 230 240 250
FRETDVLFLW DGDELVGFHW VKKHSDELQE IYVVGLAEAY RGKGLGDPLV
260 270 280 290
RLGLRHMVNG GARRVILYVE ADNDSAVAAY EKLGFTVAER HVVYEK
Length:296
Mass (Da):32,673
Last modified:March 1, 2003 - v1
Checksum:iA5BF77C99CBC108E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC19278.1.
RefSeqiWP_006769174.1. NZ_GG700685.1.

Genome annotation databases

EnsemblBacteriaiBAC19278; BAC19278; BAC19278.
KEGGicef:CE2468.
PATRICi21491083. VBICorEff9312_2436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000035 Genomic DNA. Translation: BAC19278.1.
RefSeqiWP_006769174.1. NZ_GG700685.1.

3D structure databases

ProteinModelPortaliQ8FMN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196164.HMPREF0290_0407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC19278; BAC19278; BAC19278.
KEGGicef:CE2468.
PATRICi21491083. VBICorEff9312_2436.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiMLYVDES.
OrthoDBiPOG091H09IL.

Enzyme and pathway databases

BioCyciCEFF196164:GJW8-2522-MONOMER.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF13508. Acetyltransf_7. 1 hit.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSHD_COREF
AccessioniPrimary (citable) accession number: Q8FMN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.