Reviewed, UniProtKB/Swiss-Prot Q8FMB7 (ACKA_COREF)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	CE2590

Organism

Corynebacterium efficiens [Complete proteome] [HAMAP]

Taxonomic identifier

152794 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase HAMAP MF_00020		PRO_0000107552

Sequences

	Sequence		Length	Mass (Da)
	Q8FMB7-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 517A21CF3001279F	FASTA	398	43,057
	10 20 30 40 50 60 MALALVLNSG SSSIKFQLVN PANHATDDPF VSGLVEQIGE KMGRIILKIE GEKVVKEAPI 70 80 90 100 110 120 ADHSAGLSMS FDLMTEHGCG PSQVDIIAVG HRVVHGGILF SAPELITDEI VEMIRDLIPL 130 140 150 160 170 180 APLHNPANID GIEVARRILP DVPHVAVFDT GFFHSLPPAA ALYAINKDVA AEYGIRRYGF 190 200 210 220 230 240 HGTSHEYVSS RVVDLMDKPA EEINTITFHL GNGASMAAVK GGVAVDTSMG MTPLAGLVMG 250 260 270 280 290 300 TRTGDIDPGV VFHLARNANM SIDEIDNLMN KKSGVKGLSG VNDFRELHQM IEDGDQDAWS 310 320 330 340 350 360 AYNIYIHQLR RYLGSYMVAL GRVDCLVFTA GVGENAHFVR EDALAGLEMY GIKVDPERNK 370 380 390 LPNDGPRLIS TDDSTVKVFV IPTNEELAIA RYSAKFAE

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000035 Genomic DNA. Translation: BAC19400.1.
RefSeq	NP_739200.1.
3D structure databases
HSSP	HSSP built from PDB template 1G99 based on UniProtKB P38502.
ModBase	Search...
Genome annotation databases
GeneID	1034166.
GenomeReviews	Gene locus CE2590 in contig BA000035_GR.
KEGG	cef:CE2590.
NMPDR	fig|196164.1.peg.2590.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8FMB7.
OMA	Q8FMB7. PHLKDKN.
Enzyme and pathway databases
BioCyc	CEFF196164:CE2590-MON.
BRENDA	2.7.2.1. 277326.
Family and domain databases
HAMAP	MF_00020. [Tree]
InterPro	IPR000890. Acetate_kin. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_COREF

Accession

Primary (citable) accession number: Q8FMB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 25, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)