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Q8FM44 (DCD_COREF) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxycytidine triphosphate deaminase

Short name=dCTP deaminase
EC=3.5.4.13
Gene names
Name:dcd
Ordered Locus Names:CE2663
OrganismCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395) [Complete proteome] [HAMAP]
Taxonomic identifier196164 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146

Sequence similarities

Belongs to the dCTP deaminase family.

Sequence caution

The sequence BAC19473.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processNucleotide metabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP biosynthetic process

Inferred from electronic annotation. Source: InterPro

pyrimidine ribonucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functiondCTP deaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146
PRO_0000155981

Sequences

Sequence LengthMass (Da)Tools
Q8FM44 [UniParc].

Last modified April 23, 2003. Version 2.
Checksum: 4040C9DBC70EC4D2

FASTA19321,064
        10         20         30         40         50         60 
MLLSDRDIRK SIDSGDLGID PFDPLLIQPS SIDVRMDRYF RVFNNSKYTH IDPKLNQDEL 

        70         80         90        100        110        120 
TSLVEVADGD PFVLHPGEFV LAATLEKFTL PHHLAGRLEG KSSLGRLGLL THSTAGFIDP 

       130        140        150        160        170        180 
GFSGHITLEL SNVANLPITL WPGMKVGQLA LFMMSSPAET PYGSGSLGSK YQGQRGPTPS 

       190 
KGYLNFSSEQ DSD 

« Hide

References

[1]"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000035 Genomic DNA. Translation: BAC19473.1. Different initiation.
RefSeqNP_739273.2. NC_004369.1.

3D structure databases

ProteinModelPortalQ8FM44.
SMRQ8FM44. Positions 1-186.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING196164.CE2663.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC19473; BAC19473; BAC19473.
GeneID1033851.
KEGGcef:CE2663.
PATRIC21491479. VBICorEff9312_2633.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000228601.
KOK01494.
OrthoDBEOG67DPKR.
ProtClustDBPRK00416.

Enzyme and pathway databases

BioCycCEFF196164:GJW8-2718-MONOMER.
UniPathwayUPA00610; UER00665.

Family and domain databases

HAMAPMF_00146. dCTP_deaminase.
InterProIPR011962. dCTP_deam.
IPR008180. dUTP_pyroPase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR02274. dCTP_deam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDCD_COREF
AccessionPrimary (citable) accession number: Q8FM44
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways