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Q8FM11

- TRMB_COREF

UniProt

Q8FM11 - TRMB_COREF

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, CE2696
Organism
Corynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831S-adenosyl-L-methionine By similarity
Binding sitei108 – 1081S-adenosyl-L-methionine By similarity
Binding sitei135 – 1351S-adenosyl-L-methionine By similarity
Active sitei158 – 1581 By similarity
Binding sitei158 – 1581S-adenosyl-L-methionine By similarity
Binding sitei162 – 1621Substrate By similarity
Binding sitei194 – 1941Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:CE2696
OrganismiCorynebacterium efficiens (strain DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395)
Taxonomic identifieri196164 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000001409: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000171323Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196164.CE2696.

Structurei

3D structure databases

ProteinModelPortaliQ8FM11.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni164 – 1696Interaction with RNA Reviewed prediction
Regioni232 – 2354Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000073968.
KOiK03439.
OMAiLHIATDH.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FM11-1 [UniParc]FASTAAdd to Basket

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MSISDNSREE LGELPAGRPL QSEFNDDLDY PRLGSVTFRR GTLTENQQTM    50
WNEKWPELGR VLEDELIDID AWFGRTGAKT IVEIGSGTGT STAAMAPLEA 100
DTNIIAVELY KPGLAKLMGA VVRGGIDNIR MVRGDGIEVL NRMFADGSLD 150
GVRIFFPDPW PKARHNKRRI IQSGPLNLIA KKLKPGGVLH VATDHADYAE 200
WINELVEVEP LLEYKGWPWP ECPQLTDRQV ITKFEGKGLD KDHTINEYLW 250
QKKQ 254
Length:254
Mass (Da):28,580
Last modified:March 1, 2003 - v1
Checksum:iDCE8743C7364C5A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC19506.1.
RefSeqiNP_739306.1. NC_004369.1.
WP_006768937.1. NZ_GG700685.1.

Genome annotation databases

EnsemblBacteriaiBAC19506; BAC19506; BAC19506.
GeneIDi1033792.
KEGGicef:CE2696.
PATRICi21491543. VBICorEff9312_2664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000035 Genomic DNA. Translation: BAC19506.1 .
RefSeqi NP_739306.1. NC_004369.1.
WP_006768937.1. NZ_GG700685.1.

3D structure databases

ProteinModelPortali Q8FM11.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196164.CE2696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC19506 ; BAC19506 ; BAC19506 .
GeneIDi 1033792.
KEGGi cef:CE2696.
PATRICi 21491543. VBICorEff9312_2664.

Phylogenomic databases

HOGENOMi HOG000073968.
KOi K03439.
OMAi LHIATDH.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens."
    Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.
    Genome Res. 13:1572-1579(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Entry informationi

Entry nameiTRMB_COREF
AccessioniPrimary (citable) accession number: Q8FM11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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