ID   MSRA_COREF              Reviewed;         217 AA.
AC   Q8FLU6;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 2.
DT   20-JAN-2009, entry version 35.
DE   RecName: Full=Peptide methionine sulfoxide reductase msrA;
DE            Short=Protein-methionine-S-oxide reductase;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase;
DE            Short=Peptide Met(O) reductase;
GN   Name=msrA; OrderedLocusNames=CE2764;
OS   Corynebacterium efficiens.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=152794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
RX   MEDLINE=22723752; PubMed=12840036; DOI=10.1101/gr.1285603;
RA   Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E.,
RA   Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K.,
RA   Gojobori T.;
RT   "Comparative complete genome sequence analysis of the amino acid
RT   replacements responsible for the thermostability of Corynebacterium
RT   efficiens.";
RL   Genome Res. 13:1572-1579(2003).
CC   -!- FUNCTION: Has an important function as a repair enzyme for
CC       proteins that have been inactivated by oxidation. Catalyzes the
CC       reversible oxidation-reduction of methionine sulfoxide in proteins
CC       to methionine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide +
CC       H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.
CC   -!- CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O =
CC       L-methionine (S)-S-oxide + thioredoxin.
CC   -!- SIMILARITY: Belongs to the msrA Met sulfoxide reductase family.
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DR   EMBL; BA000035; BAC19574.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_739374.1; -.
DR   HSSP; P54149; 1FVG.
DR   GeneID; 1032113; -.
DR   GenomeReviews; BA000035_GR; CE2764.
DR   KEGG; cef:CE2764; -.
DR   NMPDR; fig|196164.1.peg.2764; -.
DR   HOGENOM; Q8FLU6; -.
DR   BioCyc; CEFF196164:CE2764-MON; -.
DR   BRENDA; 1.8.4.11; 277326.
DR   GO; GO:0008113; F:peptide-methionine-(S)-S-oxide reductase ac...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006464; P:protein modification process; IEA:HAMAP.
DR   HAMAP; MF_01401; -; 1.
DR   InterPro; IPR002569; MsrA.
DR   Gene3D; G3DSA:3.30.1060.10; MsrA; 1.
DR   Pfam; PF01625; PMSR; 1.
DR   ProDom; PD003489; PMSR; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Oxidoreductase.
FT   CHAIN         1    217       Peptide methionine sulfoxide reductase
FT                                msrA.
FT                                /FTId=PRO_0000138542.
FT   ACT_SITE     56     56       By similarity.
SQ   SEQUENCE   217 AA;  24191 MW;  0E642BD96745EFD2 CRC64;
     MAFFFRPEPK MVTPEEALKG GRHPVLESPQ PHTVLGTPIT GPWKEGQKRV WIGLGCFWGV
     EQMYWKMDGV ESTSVGYAGG YTPNPTYREV CSGRTGHTEI VEVVYDPEKI TLAELVARGL
     EAHDPTQGYR QGNDVGTQYR SAFYVETGEE AETVRQIVST YGETLKSHGF GEITTEVDVI
     TPADYYLAED YHQQYLHKNP DGYCPHHSTG IPCGVEA
//