Q8FLU6 (MSRA_COREF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	CE2764

Organism

Corynebacterium efficiens [Complete proteome] [HAMAP]

Taxonomic identifier

152794 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.
Sequence caution	The sequence BAC19574.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 217	217	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_0000138542
Sites
	Active site	56	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FLU6 [UniParc]. Last modified September 27, 2005. Version 2. Checksum: 0E642BD96745EFD2	FASTA	217	24,191
	10 20 30 40 50 60 MAFFFRPEPK MVTPEEALKG GRHPVLESPQ PHTVLGTPIT GPWKEGQKRV WIGLGCFWGV 70 80 90 100 110 120 EQMYWKMDGV ESTSVGYAGG YTPNPTYREV CSGRTGHTEI VEVVYDPEKI TLAELVARGL 130 140 150 160 170 180 EAHDPTQGYR QGNDVGTQYR SAFYVETGEE AETVRQIVST YGETLKSHGF GEITTEVDVI 190 200 210 TPADYYLAED YHQQYLHKNP DGYCPHHSTG IPCGVEA

References

[1]

"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens." Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T. Genome Res. 13:1572-1579(2003) [PubMed: 12840036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000035 Genomic DNA. Translation: BAC19574.1. Different initiation.
RefSeq	NP_739374.1. NC_004369.1.
3D structure databases
ProteinModelPortal	Q8FLU6.
SMR	Q8FLU6. Positions 12-213.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1032113.
GenomeReviews	Gene locus CE2764 in contig BA000035_GR.
KEGG	cef:CE2764.
NMPDR	fig|196164.1.peg.2764.
PATRIC	21491679. VBICorEff9312_2732.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG748152.
PhylomeDB	Q8FLU6.
ProtClustDB	PRK00058.
Enzyme and pathway databases
BioCyc	CEFF196164:CE2764-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_COREF

Accession

Primary (citable) accession number: Q8FLU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	September 27, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program